Collective Molecular Activities of the Plant: Artemisia Chinensis
Plant ID: NPO4347
Plant Latin Name: Artemisia Chinensis
Taxonomy Genus: Artemisia
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
99046
Plant-of-the-World-Online:
n.a.
Country/Region:
ThailandTraditional Medicine System:
Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
47 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
18 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
10 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98320
Ingredient ID: NPC97444
Ingredient ID: NPC96010
Ingredient ID: NPC91604
Ingredient ID: NPC88686
Ingredient ID: NPC8605
Ingredient ID: NPC4785
Ingredient ID: NPC47781
Ingredient ID: NPC46981
Ingredient ID: NPC4422
Ingredient ID: NPC43055
Ingredient ID: NPC40488
Ingredient ID: NPC312750
Ingredient ID: NPC300682
Ingredient ID: NPC297712
Ingredient ID: NPC29674
Ingredient ID: NPC286405
Ingredient ID: NPC272282
Ingredient ID: NPC266187
Ingredient ID: NPC264179
Ingredient ID: NPC26027
Ingredient ID: NPC25655
Ingredient ID: NPC25270
Ingredient ID: NPC248043
Ingredient ID: NPC247691
Ingredient ID: NPC247622
Ingredient ID: NPC244497
Ingredient ID: NPC242709
Ingredient ID: NPC226941
Ingredient ID: NPC217910
Ingredient ID: NPC198641
Ingredient ID: NPC195674
Ingredient ID: NPC192690
Ingredient ID: NPC172115
Ingredient ID: NPC171929
Ingredient ID: NPC166552
Ingredient ID: NPC163524
Ingredient ID: NPC161571
Ingredient ID: NPC15898
Ingredient ID: NPC152172
Ingredient ID: NPC146334
Ingredient ID: NPC138751
Ingredient ID: NPC136073
Ingredient ID: NPC135382
Ingredient ID: NPC130444
Ingredient ID: NPC120022
Ingredient ID: NPC119803
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A3 | Solute carrier family 22 member 3 | O75751 | CHEMBL2073673 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Therapeutic Target | Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Therapeutic Target | Oxidoreductase | NQO2 | Quinone reductase 2 | P16083 | CHEMBL3959 |
| Therapeutic Target | Secreted protein | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 129 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000577 | Asthma Clinical Research Network (ACRN) | asthma;lung disease | Colchicine (NPC226941) | NP level |
| NCT00004368 | Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis | cirrhosis of liver | Colchicine (NPC226941) | NP level |
| NCT00004748 | Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis | primary biliary cirrhosis | Colchicine (NPC226941) | NP level |
| NCT00098969 | UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants | neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00128414 | Study of Colchicine to Treat and Prevent Recurrent Pericarditis (First Episode) | pericarditis | Colchicine (NPC226941) | NP level |
| NCT00128427 | Study of Colchicine to Prevent the Postpericardiotomy Syndrome | Postpericardiotomy Syndrome | Colchicine (NPC226941) | NP level |
| NCT00128453 | Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences | pericarditis | Colchicine (NPC226941) | NP level |
| NCT00256334 | Resveratrol for Patients With Colon Cancer | malignant colon neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00370760 | Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR) | proliferative vitreoretinopathy | Colchicine (NPC226941) | NP level |
| NCT00433576 | Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery | colorectal adenocarcinoma;malignant colon neoplasm;rectum cancer | Resveratrol (NPC161571) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00754819,NCT05472337,NCT05250596
|
Acute non-ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.1 |
NCT03048825
|
Acute pericarditisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB20 |
NCT00128414,NCT00128453
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT03048825
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA9,GMNN,TRPA1,CYP2D6,CA12,THPO
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SLC22A3,CA14,DPP4,PAX8,CA9,SHH,PTGS2,CYP1B1,TRPA1,TUBB6,PTGS1,LMNA
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
