CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Corydalis Crystallina

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO4125
Plant Latin Name: Corydalis Crystallina
Taxonomy Genus: Corydalis
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 66371-2

Used in Medicines

Unknown.

Geographical Distribution

United States

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

64 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

29 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

18 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC95920

Ingredient ID: NPC95381

Ingredient ID: NPC91604

Ingredient ID: NPC88186

Ingredient ID: NPC83733

Ingredient ID: NPC79835

Ingredient ID: NPC77184

Ingredient ID: NPC76902

Ingredient ID: NPC75742

Ingredient ID: NPC7479

Ingredient ID: NPC692

Ingredient ID: NPC64381

Ingredient ID: NPC56223

Ingredient ID: NPC50528

Ingredient ID: NPC4309

Ingredient ID: NPC37250

Ingredient ID: NPC33378

Ingredient ID: NPC32833

Ingredient ID: NPC30856

Ingredient ID: NPC307270

Ingredient ID: NPC307113

Ingredient ID: NPC304552

Ingredient ID: NPC284104

Ingredient ID: NPC274516

Ingredient ID: NPC273965

Ingredient ID: NPC270674

Ingredient ID: NPC268755

Ingredient ID: NPC267179

Ingredient ID: NPC26306

Ingredient ID: NPC262922

Ingredient ID: NPC25455

Ingredient ID: NPC250781

Ingredient ID: NPC243014

Ingredient ID: NPC242419

Ingredient ID: NPC232572

Ingredient ID: NPC230301

Ingredient ID: NPC22861

Ingredient ID: NPC227952

Ingredient ID: NPC2232

Ingredient ID: NPC217245

Ingredient ID: NPC216515

Ingredient ID: NPC212874

Ingredient ID: NPC205152

Ingredient ID: NPC204025

Ingredient ID: NPC195749

Ingredient ID: NPC184608

Ingredient ID: NPC180256

Ingredient ID: NPC1786

Ingredient ID: NPC175795

Ingredient ID: NPC16983

Ingredient ID: NPC169493

Ingredient ID: NPC161543

Ingredient ID: NPC160633

Ingredient ID: NPC153375

Ingredient ID: NPC151448

Ingredient ID: NPC145901

Ingredient ID: NPC139665

Ingredient ID: NPC136633

Ingredient ID: NPC129683

Ingredient ID: NPC129253

Ingredient ID: NPC126681

Ingredient ID: NPC122819

Ingredient ID: NPC119405

Ingredient ID: NPC119343

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Transcription factor	GLI1	Zinc finger protein GLI1	P08151	CHEMBL5461

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	19

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00575848	Study of the Effects of Glycine on Symptoms and Memory in Patients With Schizophrenia	schizoaffective disorder;schizophrenia	Glycine (NPC126681)	NP level
NCT00133562	HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition	malnutrition	Glycine (NPC126681)	NP level
NCT03166228	Hemodynamic Changes During Operative Hysteroscopy	hypertension	Glycine (NPC126681)	NP level
NCT01417481	Effect of Glycine in Cystic Fibrosis	cystic fibrosis	Glycine (NPC126681)	NP level
NCT01031927	N-methyl Glycine (Sarcosine) for the Treatment of Obsessive Compulsive Disorder (OCD)	obsessive-compulsive disorder	Glycine (NPC126681)	NP level
NCT00929370	A Repeat Dose Study With GSK1018921 to Assess Safety, Tolerability, Pharmacokinetics, Pharmacodynamics in Healthy Volunteers and Patients With Schizophrenia and to Evaluate Its Effect on PK of Midazolam.	schizophrenia	Glycine (NPC126681)	NP level
NCT01501942	Efficacy, Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Oral Administration of AIM-102 in Patients With Mild to Moderate Allergic Asthma	asthma	Glycine (NPC126681)	NP level
NCT00291226	Glycine vs Placebo for the Schizophrenia Prodrome	schizophrenia	Glycine (NPC126681)	NP level
NCT04703036	Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19	COVID-19	Glycine (NPC126681)	NP level
NCT00000372	Glycine and D-Cycloserine in Schizophrenia	schizophrenia	Glycine (NPC126681)	NP level
NCT04740580	Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease	Alzheimer disease	Glycine (NPC126681)	NP level
NCT03493178	Glutathione in Mild Cognitive Impairment	Cognitive impairment	Glycine (NPC126681)	NP level
NCT01720316	Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders	bipolar disorder	Glycine (NPC126681)	NP level
NCT00268749	Glycine Treatment of Prodromal Symptoms	schizophrenia	Glycine (NPC126681)	NP level
NCT00133406	Long-term Impact and Intervention for Diarrhea in Brazil	diarrheal disease	Glycine (NPC126681)	NP level
NCT00222235	Adjunctive Treatment for Decreasing Symptoms of Schizophrenia	schizoaffective disorder;schizophrenia	Glycine (NPC126681)	NP level
NCT00005658	Glycine to Treat Psychotic Disorders in Children	schizophrenia	Glycine (NPC126681)	NP level
NCT00276263	Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia	schizophrenia	Glycine (NPC126681)	NP level
NCT00338221	Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition	malnutrition	Glycine (NPC126681)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	NCT00291226,NCT00929370,NCT00222235,NCT00276263,NCT00575848,NCT00000372,NCT00005658,NCT00268749
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	OR51E2,F2,GLI1
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	F2 NCT01501942
Unspecified undernutrition Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B7Z	NCT00133562,NCT00338221
Schizoaffective disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A21	NCT00575848,NCT00222235
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	OR51E2,GLI1
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	OR51E2,GLI1
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	F2,GLI1
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	OR51E2,F2
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	OR51E2,GLI1
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	OR51E2,F2
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	OR51E2,GLI1
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	F2,GLI1
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	F2
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	F2
Bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20-GA21	F2
Thrombosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB61-GB90	F2
Coronary thrombosis Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA43	F2
Ischaemic/haemorrhagic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B20	F2
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	F2
Cerebral ischaemic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B11	F2
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	F2
Thrombocytopenia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B64	F2
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	F2
Coagulation defect Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B10	F2
Nutritional deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B50-5B71	F2
Bipolar disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A60	NCT01720316
Symptoms and signs involving cognition, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB21.Z	NCT03493178
Infectious gastroenteritis or colitis without specification of infectious agent Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A40.Z	NCT00133406
COVID-19 Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D6Y	NCT04703036
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	NCT04740580
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	NCT03166228
Obsessive-compulsive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6B20	NCT01031927
Cystic fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA25	NCT01417481
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	OR51E2
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	F2
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	OR51E2
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	F2
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	F2
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	GLI1
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	OR51E2
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	F2
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	F2
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	OR51E2
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	OR51E2

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Corydalis Crystallina

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

64 All known Ingredients in Total

29 Ingredients with Acceptable Bioavailablity

18 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Schizophrenia

Adenocarcinoma of pancreas

Asthma

Unspecified undernutrition

Schizoaffective disorder

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Squamous cell carcinoma of bronchus or lung

Mesothelioma of pleura

Other specified malignant neoplasms of kidney, except renal pelvis

Hepatocellular carcinoma of liver

Germ cell tumour of testis

Type 2 diabetes mellitus

Cardiovascular disease

Bleeding disorder

Thrombosis

Coronary thrombosis

Ischaemic/haemorrhagic stroke

Multiple sclerosis

Cerebral ischaemic stroke

Myocardial infarction

Thrombocytopenia

Angina pectoris

Coagulation defect

Nutritional deficiency

Bipolar disorder

Symptoms and signs involving cognition, unspecified

Infectious gastroenteritis or colitis without specification of infectious agent

COVID-19

Alzheimer disease

Pulmonary hypertension

Obsessive-compulsive disorder

Cystic fibrosis

Pheochromocytoma

Adenocarcinoma of stomach

Diffuse large B-cell lymphomas

Tetralogy of Fallot

Other specified malignant neoplasms ofcolon

Cytomegaloviral disease

Adenocarcinoma of prostate

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Carpal tunnel syndrome

Malignant neoplasms of adrenal gland

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities