Collective Molecular Activities of the Plant: Nauclea Rhynchophylla
Plant ID: NPO4117
Plant Latin Name: Nauclea Rhynchophylla
Taxonomy Genus: Nauclea
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
83 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
56 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
28 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9874
Ingredient ID: NPC92615
Ingredient ID: NPC90982
Ingredient ID: NPC90757
Ingredient ID: NPC89
Ingredient ID: NPC88806
Ingredient ID: NPC87213
Ingredient ID: NPC86438
Ingredient ID: NPC86249
Ingredient ID: NPC81803
Ingredient ID: NPC81010
Ingredient ID: NPC81002
Ingredient ID: NPC80600
Ingredient ID: NPC76356
Ingredient ID: NPC74351
Ingredient ID: NPC70744
Ingredient ID: NPC6984
Ingredient ID: NPC63973
Ingredient ID: NPC61461
Ingredient ID: NPC5586
Ingredient ID: NPC51570
Ingredient ID: NPC47094
Ingredient ID: NPC37468
Ingredient ID: NPC32163
Ingredient ID: NPC311986
Ingredient ID: NPC309557
Ingredient ID: NPC306244
Ingredient ID: NPC303409
Ingredient ID: NPC301377
Ingredient ID: NPC300017
Ingredient ID: NPC29883
Ingredient ID: NPC296427
Ingredient ID: NPC294470
Ingredient ID: NPC291454
Ingredient ID: NPC28983
Ingredient ID: NPC287992
Ingredient ID: NPC287301
Ingredient ID: NPC280077
Ingredient ID: NPC276808
Ingredient ID: NPC276268
Ingredient ID: NPC273070
Ingredient ID: NPC272695
Ingredient ID: NPC272537
Ingredient ID: NPC272415
Ingredient ID: NPC265007
Ingredient ID: NPC263417
Ingredient ID: NPC263367
Ingredient ID: NPC258546
Ingredient ID: NPC251102
Ingredient ID: NPC248355
Ingredient ID: NPC245561
Ingredient ID: NPC24402
Ingredient ID: NPC241105
Ingredient ID: NPC235431
Ingredient ID: NPC228346
Ingredient ID: NPC227698
Ingredient ID: NPC227678
Ingredient ID: NPC227302
Ingredient ID: NPC219913
Ingredient ID: NPC214702
Ingredient ID: NPC212770
Ingredient ID: NPC205796
Ingredient ID: NPC205054
Ingredient ID: NPC203719
Ingredient ID: NPC202472
Ingredient ID: NPC199194
Ingredient ID: NPC194416
Ingredient ID: NPC192612
Ingredient ID: NPC186418
Ingredient ID: NPC176015
Ingredient ID: NPC171721
Ingredient ID: NPC170807
Ingredient ID: NPC160345
Ingredient ID: NPC156654
Ingredient ID: NPC156502
Ingredient ID: NPC155930
Ingredient ID: NPC150919
Ingredient ID: NPC147583
Ingredient ID: NPC140201
Ingredient ID: NPC130833
Ingredient ID: NPC130754
Ingredient ID: NPC111888
Ingredient ID: NPC111625
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
| Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 4 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00992667 | Inhaled Apocynin Decreases Reactive Oxygen Species Concentrations in Exhaled Breath Condensate in Mild Asthmatics | asthma | Apocynin (NPC32163) | NP level |
| NCT01402297 | Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients | chronic obstructive pulmonary disease | Apocynin (NPC32163) | NP level |
| NCT03680573 | The Effect of Antioxidants on Skin Blood Flow-BH4 | cardiovascular disease | Apocynin (NPC32163) | NP level |
| NCT03680638 | The Effect of Antioxidants on Skin Blood Flow During Local Heating | cardiovascular disease | Apocynin (NPC32163) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA14,DRD1,SNCA,CA2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT00992667
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2,CA14
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA14,CA2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
