• Home
  • About
  • Browse
  • Help
  • Download

Collective Molecular Activities of the Plant: Trollius Europaeus


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO4061
Plant Latin Name: Trollius Europaeus
Taxonomy Genus: Trollius
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 212754
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:
Finland

Traditional Medicine System:


Medicinal Functions:

Purgative; Rubefacient; Vitamin C

Geographical Distribution

Finland

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

23 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


16 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

18 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC86452

Ingredient ID: NPC77890

Ingredient ID: NPC7013

Ingredient ID: NPC62290

Ingredient ID: NPC50898

Ingredient ID: NPC43300

Ingredient ID: NPC34103

Ingredient ID: NPC32441

Ingredient ID: NPC294409

Ingredient ID: NPC284504

Ingredient ID: NPC234560

Ingredient ID: NPC209593

Ingredient ID: NPC204761

Ingredient ID: NPC192638

Ingredient ID: NPC182729

Ingredient ID: NPC182428

Ingredient ID: NPC181124

Ingredient ID: NPC168586

Ingredient ID: NPC157658

Ingredient ID: NPC156457

Ingredient ID: NPC116775

Ingredient ID: NPC116632

Ingredient ID: NPC100720

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 Cytochrome P450 family 2 CYP2D6 Cytochrome P450 2D6 P10635 CHEMBL289
Therapeutic Target Enzyme BLM Bloom syndrome protein P54132 CHEMBL1293237
Therapeutic Target Enzyme CES1 Acyl coenzyme A:cholesterol acyltransferase P23141 CHEMBL2265
Therapeutic Target Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Therapeutic Target Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Therapeutic Target Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Therapeutic Target Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Therapeutic Target Nuclear hormone receptor subfamily 1 NR1H4 Bile acid receptor FXR Q96RI1 CHEMBL2047
Therapeutic Target Nuclear hormone receptor subfamily 3 ESRRA Estrogen-related receptor alpha P11474 CHEMBL3429
Therapeutic Target Nuclear hormone receptor subfamily 3 ESR1 Estrogen receptor alpha P03372 CHEMBL206
Therapeutic Target Nuclear hormone receptor subfamily 3 ESR2 Estrogen receptor beta Q92731 CHEMBL242
Therapeutic Target Nuclear hormone receptor subfamily 3 ESRRB Estrogen-related receptor beta O95718 CHEMBL3751
Therapeutic Target Oxidoreductase HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Therapeutic Target Oxidoreductase AOX1 Aldehyde oxidase Q06278 CHEMBL3257
Therapeutic Target Oxidoreductase HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Therapeutic Target Phosphodiesterase TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Therapeutic Target Protein Kinase MKNK2 MAP kinase signal-integrating kinase 2 Q9HBH9 CHEMBL4204
Therapeutic Target Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Therapeutic Target Protein Kinase MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 P45985 CHEMBL2897
Therapeutic Target Secreted protein THPO Thrombopoietin P40225 CHEMBL1293256
Therapeutic Target Secreted protein TTR Transthyretin P02766 CHEMBL3194
Therapeutic Target Serine protease DPP4 Dipeptidyl peptidase IV P27487 CHEMBL284
Therapeutic Target Structural protein LMNA Prelamin-A/C P02545 CHEMBL1293235
Therapeutic Target Transcription factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Therapeutic Target Transporter NPC1 Niemann-Pick C1 protein O15118 CHEMBL1293277
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level36
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT00016744 Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis) cystic fibrosis Genistein (NPC39426) NP level
NCT03848208 A Single Dose-escalation Study of Cytisine in Adult Smokers smoking cessation Cytisine (NPC77890) NP level
NCT04576949 A Study of Cytisinicline for Smoking Cessation in Adult Smokers smoking cessation Cytisine (NPC77890) NP level
NCT00590538 Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis) cystic fibrosis Genistein (NPC39426) NP level
NCT02567799 BIO 300 Non-Small Cell Lung Cancer Study non-small cell lung carcinoma Genistein (NPC39426) NP level
NCT00010686 Dietary Phytoestrogens and Bone Metabolism osteoporosis Daidzein (NPC234560);Genistein (NPC39426) NP level
NCT00287690 Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery Disease coronary artery disease Genistein (NPC39426) NP level
NCT04126135 Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy nicotine dependence Cytisine (NPC77890) NP level
NCT01325311 Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer prostate adenocarcinoma Genistein (NPC39426) NP level
NCT00290758 Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer breast cancer Genistein (NPC39426) NP level
NCT04015414 Varenicline Versus Cytisine for Smoking Cessation in Primary Care Setting smoking cessation Cytisine (NPC77890) NP level
NCT00584532 Effects of a Genistein Concentrated Polysaccharide (GCP) for Prostate Cancer on Active Surveillance. prostate cancer Genistein (NPC39426) NP level
NCT00118040 Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer urinary bladder carcinoma Genistein (NPC39426) NP level
NCT03709823 Trial of Cytisine in Adult Smokers smoking cessation Cytisine (NPC77890) NP level
NCT00001696 A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor cancer Genistein (NPC39426) NP level
NCT02585024 Cytisine Pharmacokinetics and Dose Response (C-DRAKS 3 and C-DRAKS 4) smoking cessation Cytisine (NPC77890) NP level
NCT01489813 Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment urinary bladder cancer Genistein (NPC39426) NP level
NCT00244933 Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast Cancer breast cancer Genistein (NPC39426) NP level
NCT02766478 Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate Cancer prostate cancer Genistein (NPC39426) NP level
NCT03303911 A Pharmacokinetic and Pharmacodynamic Evaluation of Cytisine in Healthy Smokers smoking cessation Cytisine (NPC77890) NP level
NCT03509948 A Study in Healthy Smokers to Investigate the Effect of Food on the Bioavailability of Cytisine in a New Formulation smoking cessation Cytisine (NPC77890) NP level
NCT04482595 BIO 300 Oral Suspension in Previously Hospitalized Long COVID Patients pulmonary fibrosis;severe acute respiratory syndrome Genistein (NPC39426) NP level
NCT01628471 MTD Determination, Safety and Efficacy of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung Cancer non-small cell lung carcinoma Genistein (NPC39426) NP level
NCT01985763 Genistein in Treatment of Metastatic Colorectal Cancer colorectal carcinoma;malignant colon neoplasm;rectum cancer Genistein (NPC39426) NP level
NCT00058266 Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy prostate cancer Genistein (NPC39426) NP level
NCT00546039 Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate Cancer prostate adenocarcinoma Genistein (NPC39426) NP level
NCT03268343 A Study in Healthy Volunteers to Investigate the Effect of Food on the Bioavailability of Cytisine smoking cessation Cytisine (NPC77890) NP level
NCT00005827 Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer prostate cancer Genistein (NPC39426) NP level
NCT00541710 Effect of Genistein in Women With Metabolic Syndrome metabolic syndrome Genistein (NPC39426) NP level
NCT01126879 Genistein in Treating Patients With Prostate Cancer prostate adenocarcinoma Genistein (NPC39426) NP level
NCT05206370 A Second Study of Cytisinicline for Smoking Cessation in Adult Smokers smoking cessation Cytisine (NPC77890) NP level
NCT01664650 Effects of Genistein in Postmenopausal Women With Metabolic Syndrome metabolic syndrome Genistein (NPC39426) NP level
NCT02957786 Cytisine Versus Varenicline for Smoking Cessation smoking cessation Cytisine (NPC77890) NP level
NCT00376948 Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer pancreatic carcinoma Genistein (NPC39426) NP level
NCT05311085 Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion) smoking cessation Cytisine (NPC77890) NP level
NCT00882765 Genistein in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery pancreatic carcinoma Genistein (NPC39426) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 CA12,ESR1,EGFR,CA4,CYP19A1,ESR2,MKNK2
 NCT00290758,NCT00244933
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 CHRNA3,BLM,CSNK2A3,LMNA,CA4,MAPT,ESR2,CSNK2A1,CHRND
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 CA12,DPP4,CHRNA4,CA4,BLM,CA7,CYP19A1,HSD17B2,CHRND
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 ESR2,AOX1,MAOB,ESR1
 NCT02766478,NCT00058266,NCT00584532,NCT00005827
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 CA4,ACHE,XDH,CHRNA3,BLM,MAPT,TTR,CHRND
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 CHRNA4,THPO,ACHE,CHRNA3,CYP1A1,CYP2C9,ESR2,ESRRB
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 XDH,BLM,CYP1A1,CYP2D6,CYP2C9,HSD17B2,ESRRB,CHRND
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 ACHE,XDH,TYR,CYP19A1,CYP2C9,TSHR,CHRND
Squamous cell carcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.2
 CA12,HSD17B1,XDH,TSHR,BLM,CA7,CYP2C9
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 DPP4,LMNA,CA4,RAB9A,ACHE,HSD17B1,ESRRB
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 CA12,CA4,CHRNA3,BLM,CYP19A1,CHRND
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 CHRNA4,LMNA,EGFR,XDH,CYP19A1,ESRRB
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 TTR,CA12,CYP1A2,ESRRA,NPC1,CYP1A1
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 DPP4,THPO,AOX1,ESR1,CYP1B1,ESRRB
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 ACHE,MAPT,CHRNA4,ESR2,MAOB
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 HSD17B1,BLM,CYP1A2,CYP2C9,TTR
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 CA12,DPP4,XDH,CYP1B1,CA7
Invasive carcinoma of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C61
 CA12,CHRNA4,THPO,ESR1,BLM
Psoriasis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA90
 DPP4,ESRRB,AHR,ESRRA
Adenocarcinoma of prostate
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82.0
 TTR
 NCT01126879,NCT01325311,NCT00546039
Metabolic disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C50-5D2Z
 DPP4
 NCT01664650,NCT00541710
Hyper-lipoproteinaemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80
 ESR1,ESR2,CES1
Parkinsonism
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00
 ACHE,MAPT,MAOB
Atopic eczema
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA80
 ESRRB,AHR,ESRRA
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 CA4,CYP2C9,CA12
Colorectal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B91
 MKNK2,EGFR
 NCT01985763
Liver cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12
 EGFR,CSNK2A1,MKNK2
Asthma
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA23
 ESRRB,ESRRA,CA4
Vasomotor/allergic rhinitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA08
 ESR2,ESRRA,ESRRB
Non-small cell lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 EGFR
 NCT02567799,NCT01628471
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 DPP4,TSHR,BLM
West Nile virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D46
 DPP4,ACHE,CYP19A1
Other specified malignant neoplasms of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.Y
 CA12,XDH,HSD17B1
Systemic lupus erythematosus
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A40.0
 ACHE,CYP1A1,ESRRB
Mild neurocognitive disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D71
 MAPT,ACHE
Myocardial infarction
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA41-BA43
 DPP4,THPO
Myelodysplastic syndrome
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A37
 AHR,EGFR
Glaucoma
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C61
 CA4,ACHE
Acquired hypomelanotic disorder
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED63
 TYR,MAOB
Postoperative inflammation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-CA43
 ESRRA,ESRRB
Seborrhoeic dermatitis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA81
 CA12,CA4
Depression
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A70-6A7Z
 MAOB,CHRNA4
Hepatitis virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E50-1E51
 ESR2,EGFR
Dementia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D80-6D8Z
 MAOB,ACHE
Cushing syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A70
 ESR2,CYP19A1
Inflammatory arthropathy
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA2Z
 ESRRB,ESRRA
Nicotine use disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C4A
 CHRNA4
 NCT04126135
Melanoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 EGFR,TYR
Brain cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00
 ESR1,EGFR
Skin disease
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA00-EM0Z
 ESRRB,ESRRA
Contact dermatitis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EK00-EK0Z
 ESRRB,ESRRA
Menopausal disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA30
 ESR2,ESR1
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 EGFR,MKNK2
Eyelid inflammatory disorder
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9A02
 ESRRB,ESRRA
Diabetes mellitus, type unspecified
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A14
 ESR1,DPP4
Malaria
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F40-1F45
 CYP2D6,MAOB
Chronic arterial occlusive disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD4Z
 CES1,DPP4
Endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10
 ESR1,CYP19A1
Malignant neoplasm of pancreas, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.Z
 NCT00882765,NCT00376948
Cystic fibrosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA25
 NCT00590538,NCT00016744
Idiopathic pulmonary fibrosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB03.4
 CHRNA4
 NCT04482595
Coeliac disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA95
 TSHR,CYP1A1
Myelodysplastic syndromes, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A3Z
 CYP2C9,TSHR
Osteoarthritis, unspecified
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA0Z
 CA12,HSD17B2
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 BLM,CYP19A1
Myotonic dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C71.0
 CYP1A1,CHRND
Tetralogy of Fallot
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA88.2
 CA4,ESRRB
Other specified malignant neoplasms ofcolon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 TYR,CYP1A1
Malignant neoplasms of oesophagus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 ACHE,BLM
Heart failure, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD1Z
 CHRNA3,CYP1B1
Ebola virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D60.01
 ACHE,HSD17B2
Gliomas of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.0
 AHR,BLM
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 THPO,EGFR,ACHE,TSHR,CHRNA3,BLM,AHR,PSMB5,CA12,LMNA,TDP1,ESR2,CISD1,MAOB,CSNK2A2,CSNK2A1,AOX1
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 XDH,TSHR,CHRNA3,AHR,ESRRB,PSMB5,CA12,CSNK2A3,TDP1,ESR1,CYP1A2,HSD17B2,CISD1,CSNK2A1,ESRRA,CHRND
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 DPP4,LMNA,CISD1,MAOB,ACHE,XDH,CES1,NPC1,CHRNA3,BLM,CYP1B1,CA7,CYP2C9,TTR,HSD17B2
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 CHRNA4,XDH,TSHR,CHRNA3,ESRRB,PSMB5,TDP1,CA7,HSD17B2,DPP4,CISD1,CYP19A1,ESRRA,CHRND
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 EGFR,XDH,AHR,CA12,LMNA,TDP1,TYR,CA7,HSD17B2,DPP4,CSNK2A2,AOX1,NPC1
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 CA12,DPP4,CA4,RAB9A,ACHE,XDH,ESRRA,CHRNA3,BLM,AHR,CYP2C9,TTR,HSD17B2
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 AOX1,CA4,EGFR,XDH,AHR,MKNK2,ESR1,CA12,ESRRA,ESRRB,CSNK2A1
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 CA12,CA4,CHRNA3,BLM,MAPT,CYP19A1,CHRND,CA12,CYP19A1,MAPT
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 CA12,THPO,ACHE,XDH,TSHR,BLM,CA7,CYP2D6,CYP2C9,TTR
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 DPP4,CISD1,ACHE,CHRND,CYP1B1,MAPT,CYP2C9,HSD17B2,ESRRB,PSMB5
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 CA12,CSNK2A3,LMNA,DPP4,AOX1,RAB9A,TSHR,BLM,CYP1B1,CYP19A1
Gout
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA25
 XDH
Pain, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG3Z
 ACHE
Nausea/vomiting
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MD90
 MAOB
Low bone mass disorder
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83
 ESR1
Female infertility
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA31
 ESR1
Inborn purine/pyrimidine/nucleotide metabolism error
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C55
 XDH
Malignant haematopoietic neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B33
 DPP4
Multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40
 ESR1
Head and neck cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D42
 EGFR
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 MAPT
Irritable bowel syndrome
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD91
 CHRNA4
Corneal disease
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9A76-9A78
 CHRNA4
Oesophageal/gastroduodenal disorder
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD90
 ACHE
Sepsis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1G40-1G41
 ESR2
Chronic pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30
 EGFR
Mood disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A60-6E23
 CHRNA4
Insomnia
Disease Category: 07.Sleep-wake disorders
Disease ICD-11 Code: 7A00-7A0Z
 CYP2D6
Hypertensive crisis
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA03
 CHRNA4
Degenerative high myopia
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B76
 ESRRA
Skin tag/polyp
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EK71
 MAOB
Acne vulgaris
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED80
 ESR1
Chronic kidney disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61
 XDH
Influenza
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E30-1E32
 XDH
Myasthenia gravis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C6Y
 ACHE
Malignant mesenchymal neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5D-2B5Y
 EGFR
Hypo-thyroidism
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A00
 TSHR
Oesophagitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA24
 CYP19A1
Hypotension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA20-BA21
 CHRNA4
Acquired prion disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E01
 ESR1
Ischemia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B10-8B11
 EGFR
Thrombocytopenia
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B64
 AHR
Menstrual cycle bleeding disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA20
 ESR1
Unspecific body region injury
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: ND56
 EGFR
Dyspareunia
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA12
 ESR1
Primary psychotic disorder manifestation
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A25
 MAOB
Lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 EGFR
Testicular cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80
 EGFR
Nasopharyngeal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6B
 EGFR
Skin postprocedural disorder
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EL8Y
 EGFR
Stomach cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72
 EGFR
Parasitic worm infestation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F90
 ACHE
Breast in situ carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E65
 ESR1
Muscular dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C70
 MAOB
Aneurysm/dissection
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD50
 CHRNA4
Multiple myeloma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A83
 AHR
Metastatic lymph node neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60
 EGFR
Diabetic foot ulcer
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD54
 EGFR
Prostate hyperplasia
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA90
 ESR2
Attention deficit hyperactivity disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A05
 CHRNA4
Ureteral cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C92
 AHR
Spinal cord/cranial nerve neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A02
 EGFR
Fungal infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F29-1F2F
 RAB9A
Pituitary gland disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A60-5A61
 ESR1
Indeterminate colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD72
 ESR2
Mineral deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B5K
 XDH
Rheumatoid arthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA20
 ESRRA
Urethral cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C93
 EGFR
Intracerebral haemorrhage
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B00
 EGFR
Metastatic tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D50-2E2Z
 ESR1
Autism spectrum disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A02
 DPP4
Thyroid cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10
 TSHR
Female pelvic pain
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA34
 ESR1
Choreiform disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A01
 MAPT
Type 2 diabetes mellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A11
 DPP4
Coronavirus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D92
 CSNK2A1
Cardiomyopathy
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC43
 TTR
Pulmonary hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BB01
 MAOB
Substance abuse
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40
 ACHE
Heart failure
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD10-BD1Z
 XDH
Adrenal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 ESR1
Acquired hypermelanosis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED60
 TYR
Colon cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 EGFR
Acute diabete complication
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A2Y
 DPP4
Peroxisomal disease
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C57
 CES1
Unspecified viral infection of unspecified site
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D9Z
 ESR1
Ischaemic/haemorrhagic stroke
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B20
 THPO
Migraine
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A80
 MAOB
Renal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90
 EGFR
Male infertility
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB04
 ESR1
Amyloidosis
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5D00
 TTR
Encephalopathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E47
 XDH
Skeletal anomaly
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD24
 ESR1
General pain disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E43
 MAOB
Pancreatic cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10
 EGFR
Female genital tract noninflammatory disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA1Y
 ESR1
Metastatic biliary tract neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C14-2C17
 EGFR
Pediculosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1G00
 ACHE
Vaginitis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA02
 ESR1
Neuropathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C0Z
 CYP19A1
Skin cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30-2C37
 MAOB
Mature B-cell leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A82
 EGFR
Digestive system disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DE2Z
 CHRNA4
Schizophrenia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A20
 ESRRA
Vitamin deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B55-5B5F
 AOX1
Unspecific substance harmful effect
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NE6Z
 ACHE
Hypopharyngeal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6D
 EGFR
Angina pectoris
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA40
 EGFR
Synthesis disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C52-5C59
 CES1
Osteoporosis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83.1
 NCT00010686
Rectum cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B92
 NCT01985763
coronary artery disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA8Y-BA8Z
 NCT00287690
Malignant neoplasms of colon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 NCT01985763
Malignant neoplasms of bladder, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.Z
 NCT01489813
Unspecified malignant neoplasms of unspecified sites
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D4Z
 NCT00001696
Neoplasms of unknown behaviour of urinary organs
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2F98
 NCT00118040
Severe acute respiratory syndrome
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D65
 NCT04482595
Zika virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D48
 ACHE
Atrial fibrillation
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC81.3
 CA7
Keratoconus
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9A78.50
 CA4
Pre-eclampsia
Disease Category: 18.Pregnancy, childbirth or the puerperium
Disease ICD-11 Code: JA24
 CA4
Melanoma of skin
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 TTR
Pneumonia due to Pseudomonasaeruginosa
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA40.05
 DPP4
Chronic rhinosinusitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0A
 CYP1A1

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

CMAUP

Home

About

Browse

Help

Useful links

BIDD home

NPASS database

TCM-ID database

TTD database

Contact

826 Zhangheng Road, Pudong New District, Shanghai, China

Principle Investigator:
Prof. Chen Yu Zong
chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
dyhou22@m.fudan.edu.cn
Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
yhfeng22@m.fudan.edu.cn

© 2023 Copyright: Bioinformatics & Drug Design group