Plant ID: NPO3963
Plant Latin Name: Hortonia Floribunda
Taxonomy Genus: Hortonia
Taxonomy Family: Monimiaceae
NCBI TaxonomyDB:
74875
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC9874
Ingredient ID: NPC93433
Ingredient ID: NPC92615
Ingredient ID: NPC91871
Ingredient ID: NPC90982
Ingredient ID: NPC90757
Ingredient ID: NPC88806
Ingredient ID: NPC87725
Ingredient ID: NPC87213
Ingredient ID: NPC86438
Ingredient ID: NPC86249
Ingredient ID: NPC85726
Ingredient ID: NPC81803
Ingredient ID: NPC81010
Ingredient ID: NPC81002
Ingredient ID: NPC80600
Ingredient ID: NPC80103
Ingredient ID: NPC78445
Ingredient ID: NPC76356
Ingredient ID: NPC76336
Ingredient ID: NPC74351
Ingredient ID: NPC74331
Ingredient ID: NPC73369
Ingredient ID: NPC71778
Ingredient ID: NPC70744
Ingredient ID: NPC6984
Ingredient ID: NPC63973
Ingredient ID: NPC61461
Ingredient ID: NPC5586
Ingredient ID: NPC53639
Ingredient ID: NPC52086
Ingredient ID: NPC51717
Ingredient ID: NPC51570
Ingredient ID: NPC49555
Ingredient ID: NPC47094
Ingredient ID: NPC37947
Ingredient ID: NPC37468
Ingredient ID: NPC35700
Ingredient ID: NPC35300
Ingredient ID: NPC34770
Ingredient ID: NPC34103
Ingredient ID: NPC32163
Ingredient ID: NPC311986
Ingredient ID: NPC309557
Ingredient ID: NPC306244
Ingredient ID: NPC303409
Ingredient ID: NPC301377
Ingredient ID: NPC300017
Ingredient ID: NPC29883
Ingredient ID: NPC296427
Ingredient ID: NPC294470
Ingredient ID: NPC291454
Ingredient ID: NPC290598
Ingredient ID: NPC28983
Ingredient ID: NPC288943
Ingredient ID: NPC287992
Ingredient ID: NPC287301
Ingredient ID: NPC284323
Ingredient ID: NPC280077
Ingredient ID: NPC279921
Ingredient ID: NPC276808
Ingredient ID: NPC276268
Ingredient ID: NPC273070
Ingredient ID: NPC272695
Ingredient ID: NPC272537
Ingredient ID: NPC272415
Ingredient ID: NPC271985
Ingredient ID: NPC269367
Ingredient ID: NPC265007
Ingredient ID: NPC263417
Ingredient ID: NPC263367
Ingredient ID: NPC262725
Ingredient ID: NPC258546
Ingredient ID: NPC25772
Ingredient ID: NPC251102
Ingredient ID: NPC250476
Ingredient ID: NPC248355
Ingredient ID: NPC245561
Ingredient ID: NPC24402
Ingredient ID: NPC241465
Ingredient ID: NPC241105
Ingredient ID: NPC241055
Ingredient ID: NPC241025
Ingredient ID: NPC240722
Ingredient ID: NPC235431
Ingredient ID: NPC230301
Ingredient ID: NPC228346
Ingredient ID: NPC227698
Ingredient ID: NPC227678
Ingredient ID: NPC227302
Ingredient ID: NPC226618
Ingredient ID: NPC225665
Ingredient ID: NPC224673
Ingredient ID: NPC219913
Ingredient ID: NPC214702
Ingredient ID: NPC212770
Ingredient ID: NPC20610
Ingredient ID: NPC205796
Ingredient ID: NPC205689
Ingredient ID: NPC205372
Ingredient ID: NPC205054
Ingredient ID: NPC203719
Ingredient ID: NPC202472
Ingredient ID: NPC199194
Ingredient ID: NPC194416
Ingredient ID: NPC192612
Ingredient ID: NPC186418
Ingredient ID: NPC186237
Ingredient ID: NPC182432
Ingredient ID: NPC176015
Ingredient ID: NPC171721
Ingredient ID: NPC170807
Ingredient ID: NPC167539
Ingredient ID: NPC160345
Ingredient ID: NPC160100
Ingredient ID: NPC156654
Ingredient ID: NPC156502
Ingredient ID: NPC155930
Ingredient ID: NPC150919
Ingredient ID: NPC147583
Ingredient ID: NPC145879
Ingredient ID: NPC145054
Ingredient ID: NPC141799
Ingredient ID: NPC140201
Ingredient ID: NPC13789
Ingredient ID: NPC131885
Ingredient ID: NPC130833
Ingredient ID: NPC130754
Ingredient ID: NPC127816
Ingredient ID: NPC12210
Ingredient ID: NPC111888
Ingredient ID: NPC111625
Ingredient ID: NPC110899
Ingredient ID: NPC109418
Ingredient ID: NPC10789
Ingredient ID: NPC102516
Ingredient ID: NPC100079
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
Therapeutic Target | Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 4 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00992667 | Inhaled Apocynin Decreases Reactive Oxygen Species Concentrations in Exhaled Breath Condensate in Mild Asthmatics | asthma | Apocynin (NPC32163) | NP level |
NCT01402297 | Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients | chronic obstructive pulmonary disease | Apocynin (NPC32163) | NP level |
NCT03680573 | The Effect of Antioxidants on Skin Blood Flow-BH4 | cardiovascular disease | Apocynin (NPC32163) | NP level |
NCT03680638 | The Effect of Antioxidants on Skin Blood Flow During Local Heating | cardiovascular disease | Apocynin (NPC32163) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2,CA14,CA9,PPARG,SNCA,CA2,DRD1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
F2,CA14,SNCA,DRD1,AKR1B1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
PPARG,CA2,CA9,CA14
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA14,CA9,CA2,AKR1B1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
GFER,TRIM24,CA9,AKR1B1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA2,AKR1B1,CYP1A2,CA9
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
TRIM24,CA9,DRD1,AKR1B1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
PPARG,SNCA,MAOA
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
DRD1,MAOA,SNCA
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
PPARG,AKR1B1,CA2
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA9,CA2,CA14
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
NCT03680573,NCT03680638 |
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA9,CYP1A2,CA2
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA2,CA14,SNCA
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CA9,F2,CA9
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
DRD1,CA9,SNCA
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA9,TRIM24,CA9
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CA2,CA14,KDM4E
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CA2,F2,CA9
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
F2,PPARG
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARG,F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
NCT00992667 |
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
DRD1,AKR1B1
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AKR1B1,F2
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
PPARG,DRD1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CA2,AKR1B1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,PPARG
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2,CA14
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CA9,AKR1B1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
AKR1B1,TRIM24
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,DRD1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
F2,CA9
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
F2,CA9
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F2,CA14
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
F2,CA9
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
CA2,SNCA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,CA9
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA9,CA2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A2,CA2
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
SNCA,CA9
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
PPARG
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MAOA
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
AKR1B1
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
|
Tic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A05 |
DRD1
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
MAOA
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARG
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
DRD1
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
DRD1
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
MAOA
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARG
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOA
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARG
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA2
|
Inborn metabolism deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5C59 |
CA14
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
PPARG
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
Sjogren syndromeDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A43 |
PPARG
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
PPARG
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
PPARG
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
PPARG
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
MAOA
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
MAOA
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
DRD1
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARG
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT01402297
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
MAOA
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
AKR1B1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA9
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CA9
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
PPARG
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA9
|