Collective Molecular Activities of the Plant: Medinilla Magnifica
Plant ID: NPO3905
Plant Latin Name: Medinilla Magnifica
Taxonomy Genus: Medinilla
Taxonomy Family: Melastomataceae
Plant External Links:
NCBI TaxonomyDB:
1799599
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
85 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
54 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
39 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97282
Ingredient ID: NPC97004
Ingredient ID: NPC92369
Ingredient ID: NPC86418
Ingredient ID: NPC70744
Ingredient ID: NPC67650
Ingredient ID: NPC66225
Ingredient ID: NPC60548
Ingredient ID: NPC5599
Ingredient ID: NPC54366
Ingredient ID: NPC53773
Ingredient ID: NPC51700
Ingredient ID: NPC50266
Ingredient ID: NPC49720
Ingredient ID: NPC46801
Ingredient ID: NPC45782
Ingredient ID: NPC37250
Ingredient ID: NPC36434
Ingredient ID: NPC36047
Ingredient ID: NPC313179
Ingredient ID: NPC311057
Ingredient ID: NPC307783
Ingredient ID: NPC29883
Ingredient ID: NPC298821
Ingredient ID: NPC295275
Ingredient ID: NPC288807
Ingredient ID: NPC283804
Ingredient ID: NPC27657
Ingredient ID: NPC272400
Ingredient ID: NPC270043
Ingredient ID: NPC264811
Ingredient ID: NPC264317
Ingredient ID: NPC257587
Ingredient ID: NPC248869
Ingredient ID: NPC248867
Ingredient ID: NPC244229
Ingredient ID: NPC243728
Ingredient ID: NPC240756
Ingredient ID: NPC235279
Ingredient ID: NPC235262
Ingredient ID: NPC233681
Ingredient ID: NPC233657
Ingredient ID: NPC230301
Ingredient ID: NPC228346
Ingredient ID: NPC219913
Ingredient ID: NPC217612
Ingredient ID: NPC217439
Ingredient ID: NPC215412
Ingredient ID: NPC214973
Ingredient ID: NPC213370
Ingredient ID: NPC211756
Ingredient ID: NPC203468
Ingredient ID: NPC199652
Ingredient ID: NPC199116
Ingredient ID: NPC198798
Ingredient ID: NPC189312
Ingredient ID: NPC187937
Ingredient ID: NPC179950
Ingredient ID: NPC179587
Ingredient ID: NPC17810
Ingredient ID: NPC171928
Ingredient ID: NPC171736
Ingredient ID: NPC170035
Ingredient ID: NPC169749
Ingredient ID: NPC169456
Ingredient ID: NPC164905
Ingredient ID: NPC164512
Ingredient ID: NPC161155
Ingredient ID: NPC159418
Ingredient ID: NPC156461
Ingredient ID: NPC152384
Ingredient ID: NPC150323
Ingredient ID: NPC149184
Ingredient ID: NPC145935
Ingredient ID: NPC137894
Ingredient ID: NPC136951
Ingredient ID: NPC133671
Ingredient ID: NPC131310
Ingredient ID: NPC131192
Ingredient ID: NPC131122
Ingredient ID: NPC123761
Ingredient ID: NPC108339
Ingredient ID: NPC105559
Ingredient ID: NPC104405
Ingredient ID: NPC10211
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 56 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
| NCT00006202 | Lutein for Age-Related Macular Degeneration | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00029289 | Effects of Lutein in Retinitis Pigmentosa | retinitis pigmentosa | Lutein (NPC313179) | NP level |
| NCT00121589 | Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60 | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00275418 | Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease | Crohn's disease | Beta Carotene (NPC17810) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,KDM1A,TOP2A,RELA
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT00284323,NCT01747174
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SLCO1B1,TSHR,CA12,TOP2A,F2,ACHE,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
POLB,CES1,ADORA2A,DRD1,CYP1B1,SNCA,PIM1,RECQL,F2,CA2,ADORA3,ACHE,CA7
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1,SLCO1B1,TOP2A,F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
