CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Scopolia Japonica

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO3890
Plant Latin Name: Scopolia Japonica
Taxonomy Genus: Scopolia
Taxonomy Family: Solanaceae

Plant External Links:

NCBI TaxonomyDB: 221162
Plant-of-the-World-Online: 818000-1

Used in Medicines

Country/Region:

South Korea; China; Romania

Traditional Medicine System:

TCM

Medicinal Functions:

Anodyne; Antispasmodic; Antitussive; Diuretic; Sedative

Geographical Distribution

Japan; Romania; China; South Korea; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

72 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

69 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

30 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC98929

Ingredient ID: NPC98121

Ingredient ID: NPC97820

Ingredient ID: NPC96294

Ingredient ID: NPC9556

Ingredient ID: NPC8965

Ingredient ID: NPC84281

Ingredient ID: NPC76336

Ingredient ID: NPC74559

Ingredient ID: NPC71498

Ingredient ID: NPC69389

Ingredient ID: NPC46780

Ingredient ID: NPC40037

Ingredient ID: NPC36661

Ingredient ID: NPC33541

Ingredient ID: NPC327589

Ingredient ID: NPC306626

Ingredient ID: NPC302857

Ingredient ID: NPC298093

Ingredient ID: NPC291027

Ingredient ID: NPC28959

Ingredient ID: NPC287708

Ingredient ID: NPC284820

Ingredient ID: NPC283790

Ingredient ID: NPC274810

Ingredient ID: NPC270030

Ingredient ID: NPC268183

Ingredient ID: NPC267466

Ingredient ID: NPC267413

Ingredient ID: NPC267212

Ingredient ID: NPC266576

Ingredient ID: NPC262047

Ingredient ID: NPC25281

Ingredient ID: NPC251298

Ingredient ID: NPC249797

Ingredient ID: NPC249626

Ingredient ID: NPC248299

Ingredient ID: NPC248142

Ingredient ID: NPC244364

Ingredient ID: NPC237663

Ingredient ID: NPC234378

Ingredient ID: NPC234255

Ingredient ID: NPC233910

Ingredient ID: NPC222837

Ingredient ID: NPC222558

Ingredient ID: NPC22117

Ingredient ID: NPC211401

Ingredient ID: NPC209773

Ingredient ID: NPC207703

Ingredient ID: NPC203064

Ingredient ID: NPC200302

Ingredient ID: NPC192686

Ingredient ID: NPC19097

Ingredient ID: NPC190558

Ingredient ID: NPC180340

Ingredient ID: NPC177480

Ingredient ID: NPC172518

Ingredient ID: NPC16953

Ingredient ID: NPC169485

Ingredient ID: NPC167976

Ingredient ID: NPC165549

Ingredient ID: NPC156590

Ingredient ID: NPC156194

Ingredient ID: NPC152477

Ingredient ID: NPC151003

Ingredient ID: NPC144312

Ingredient ID: NPC134160

Ingredient ID: NPC120593

Ingredient ID: NPC119209

Ingredient ID: NPC117351

Ingredient ID: NPC116631

Ingredient ID: NPC108450

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Therapeutic Target	Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Therapeutic Target	Methyl-lysine/arginine binding protein	SMN1	Survival motor neuron protein	Q16637	CHEMBL1293232
Therapeutic Target	Oxidoreductase	ND4	NADH-ubiquinone oxidoreductase chain 4	P03905	CHEMBL4499
Therapeutic Target	Phosphodiesterase	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Therapeutic Target	Protein Kinase	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Therapeutic Target	Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Therapeutic Target	Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Therapeutic Target	Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Therapeutic Target	Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Therapeutic Target	Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Therapeutic Target	Unclassified protein	PMP22	Peripheral myelin protein 22	Q01453	CHEMBL1293298

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	6

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT02136342	Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer	cancer	Chlorogenic Acid (NPC302857)	NP level
NCT03751592	Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer	lung cancer	Chlorogenic Acid (NPC302857)	NP level
NCT02728349	Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma	glioblastoma multiforme	Chlorogenic Acid (NPC302857)	NP level
NCT02245204	Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers	cancer	Chlorogenic Acid (NPC302857)	NP level
NCT02621060	Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance	abnormal glucose tolerance	Chlorogenic Acid (NPC302857)	NP level
NCT03758014	Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients	glioblastoma multiforme	Chlorogenic Acid (NPC302857)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	CA12,SMN1,CA9,TDP1,PMP22,LMNA,AKR1B1
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	CA12,SMN1,CA9,TDP1,DRD1,LMNA
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	CHRM3,CHRM1,CHRM2,CHRM5,AKR1B1
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CHRM5,CA12,CA9,MTOR,CHRM1
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	CA9,TDP1,HTR6,AKR1B1,CHRM1
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CA12,CA9,TDP1,HTR6,CHRM1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CA9,PMP22,DRD1,LMNA,CYP2C19
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	CA12,CA9,CHRM3,CA12,CA9
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CYP2C19,CHRM5,HTR6,KDM4E,CHRM1
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	HTR6,CHRM1,AKR1B1,DRD1
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	HTR6,DRD1,CHRM1,CHRM5
Peptic ulcer Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA61	CHRM5,CHRM1,CHRM3,CHRM2
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	CHRM2,HTR6,CHRM3,CHRM1
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	CA9,PMP22,LMNA,AKR1B1
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	CA12,PMP22,AKR1B1,CHRM3
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CA12,DRD1,SMN1,AKR1B1
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	CA12,CHRM2,CA9,CHRM3
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	MTOR,CA12,CA9
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	CHRM5,MTOR,DRD1
Chronic obstructive pulmonary disease Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA22	CHRM5,CHRM1,CHRM3
Functional bladder disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GC50	CHRM1,CHRM3,CHRM5
Abnormal micturition Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MF50	CHRM2,CHRM5,CHRM1
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	CHRM5,CHRM2,CHRM3
Sebaceous gland disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED91	CHRM3,CHRM2,CHRM1
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	AKR1B1,CHRM5,MTOR
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	CA9,HTR6,CA9
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	CYP2D6,CA12,CA9
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	HTR6,CA9,CYP2D6
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	DRD1,CA9,AKR1B1
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CA12,CA9,LMNA
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	MTOR,CA9
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	CHRM1,HTR6
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	HTR6,CHRM1
Renal cell carcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90	MTOR,CA9
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	CHRM1,HTR6
Neuropathy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C0Z	CHRM1,AKR1B1
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	CHRM5,CHRM1
Muscular atrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B61	SMN2,SMN1
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	DRD1,CHRM1
Tonus and reflex abnormality Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB47	CHRM3,CHRM5
Respiratory system disease Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB40-CB7Z	CHRM2,CHRM3
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	MTOR NCT03751592
Unspecified malignant neoplasms of unspecified sites Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D4Z	NCT02245204,NCT02136342
Glioblastoma, primary, NOS Disease Category: X.Extension Codes Disease ICD-11 Code: XH0MB1	NCT02728349,NCT03758014
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	CA9,CHRM5
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	CA12,CA9
Other specified malignant neoplasms of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.Y	CA12,CA9
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	PMP22,LMNA
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CA9,AKR1B1
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CA12,CA9
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CA12,CHRM1
Sjogren syndrome Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A43	CHRM3
Arteries/arterioles disorder Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD52	MTOR
Endometrial cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76	MTOR
Psychotic disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20-6A25	DRD1
Schizoaffective disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A21	CHRM1
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	MTOR
Anterior uveitis Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A96	CHRM5
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	MTOR
Gastric ulcer Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA60	CHRM1
Pleomorphic sarcoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B54	MTOR
Infectious gastroenteritis/colitis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A40	CHRM5
Hyperhidrosis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EE00	CHRM1
Brain disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70-8E61	CHRM5
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	AKR1B1
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA12
Gastritis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA42	CHRM5
Abdominal pelvic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD81	CHRM1
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	HTR6
Epileptic encephalopathy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A62	CHRM1
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	CYP2D6
Female pelvic pain Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA34	CHRM5
Head and neck cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D42	MTOR
Oesophagus motility disorder Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA21	CHRM5
Abortion Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA00	DRD1
Thrombosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB61-GB90	AKR1B1
Hydrocephalus Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8D64	MTOR
Pleural mesothelioma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26	MTOR
Chronic myelomonocytic leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A40	MTOR
Transplant rejection Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE84	MTOR
Digestive system disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DE2Z	CHRM5
Cocaine use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C45	DRD1
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	AKR1B1
Tic disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A05	DRD1
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	CHRM3
Allergic/hypersensitivity disorder Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A80-4A8Z	DRD1
Liver cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12	MTOR
Appearance/behaviour symptom Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB23	CHRM5
Muscle disorder Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB32-FB3Z	CHRM2
Cognition symptoms/signs/clinical sympton Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB21	CHRM5
Malignant mesenchymal neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B5D-2B5Y	MTOR
Bladder cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	MTOR
General examination Disease Category: 24.Factors influencing health status or contact with health services Disease ICD-11 Code: QA00	CHRM5
Metastatic lymph node neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60	MTOR
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA12
Cataract Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9B10	AKR1B1
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CYP2D6
Cough Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD12	CHRM5
Unspecific substance harmful effect Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE6Z	CHRM5
Nystagmus Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C84	CHRM5
Intellectual development disorder Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LD90	CHRM1
Dissociative neurological symptom disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6B60	HTR6
Central and peripheral nervous disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A04-8E7Z	CHRM5
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	CHRM1
Neurodegenerative disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20-8A23	HTR6
Pancreatitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DC31-DC34	CHRM5
Lymphangioleiomyomatosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB07	MTOR
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	MTOR
Corneal disease Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A76-9A78	CHRM1
Dyslipidemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80-5C81	CHRM1
Polyuria Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MF55	CHRM5
Dystonic disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A02	CHRM1
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	MTOR
Urgency Disease Category: NA Disease ICD-11 Code: N.A.	CHRM5
Impaired glucose tolerance Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A40.1	NCT02621060
Hypertrophic cardiomyopathy Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BC43.1	CHRM3
Osteoarthritis, unspecified Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA0Z	CA12
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	AKR1B1
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	DRD1
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	CA9
Chronic rhinosinusitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA0A	CA9
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	CHRM5
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	CA12
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	HTR6

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Scopolia Japonica

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

72 All known Ingredients in Total

69 Ingredients with Acceptable Bioavailablity

30 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Diffuse large B-cell lymphomas

Mesothelioma of pleura

Glaucoma

Solid tumour/cancer

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Adenocarcinoma of pancreas

Hepatocellular carcinoma of liver

Cytomegaloviral disease

Schizophrenia

Parkinsonism

Peptic ulcer

Pheochromocytoma

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Germ cell tumour of testis

Malignant neoplasms of adrenal gland

Breast cancer

Pulmonary hypertension

Chronic obstructive pulmonary disease

Functional bladder disorder

Abnormal micturition

Asthma

Sebaceous gland disorder

Pain, unspecified

Other specified malignant neoplasms of kidney, except renal pelvis

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Malignant neoplasms of thymus

Glioblastoma of brain

Mature T-cell lymphoma

Mild neurocognitive disorder

Obesity

Renal cell carcinoma

Alzheimer disease

Neuropathy

Irritable bowel syndrome

Muscular atrophy

Dementia

Tonus and reflex abnormality

Respiratory system disease

Lung cancer

Unspecified malignant neoplasms of unspecified sites

Glioblastoma, primary, NOS

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Squamous cell carcinoma of bronchus or lung

Other specified malignant neoplasms of bronchus or lung

Superficial ovarian endometriosis

Urothelial carcinoma of bladder

Invasive carcinoma of breast

Renal cell carcinoma, chromophobe type

Sjogren syndrome

Arteries/arterioles disorder

Endometrial cancer

Psychotic disorder

Schizoaffective disorder

Multiple myeloma

Anterior uveitis

Prostate cancer

Gastric ulcer

Pleomorphic sarcoma