Collective Molecular Activities of the Plant: Ruta Graveolens
Plant ID: NPO3854
Plant Latin Name: Ruta Graveolens
Taxonomy Genus: Ruta
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
37565
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Brazil; Madagascar; Italy; Swaziland; Portugal; South Africa; Philippines; Finland; India; Zimbabwe; Algeria; Chile; Greece; Angola; Argentina; China; Spain; BulgariaTraditional Medicine System:
Indian Folk; Unani; Siddha; Ayurveda; TCM; HomeopathyMedicinal Functions:
Abortifacient; Anthelmintic; Antidiarrhoeal; Antidote; Antiinflammatory; Antispasmodic; Carminative; Emetic; Emmenagogue; Expectorant; Haemostatic; Homeopathy; Ophthalmic; Rubefacient; Stimulant; Stomachic
Brazil; Turkey; Madagascar; Angola; Portugal; Algeria; South Africa; Philippines; Finland; India; Swaziland; Zimbabwe; China; Chile; Greece; Italy; Argentina; Spain; Bulgaria
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
119 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
108 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
50 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97541
Ingredient ID: NPC96699
Ingredient ID: NPC91620
Ingredient ID: NPC88846
Ingredient ID: NPC88445
Ingredient ID: NPC85613
Ingredient ID: NPC81016
Ingredient ID: NPC76006
Ingredient ID: NPC75881
Ingredient ID: NPC74539
Ingredient ID: NPC72627
Ingredient ID: NPC62943
Ingredient ID: NPC60720
Ingredient ID: NPC60503
Ingredient ID: NPC54416
Ingredient ID: NPC5167
Ingredient ID: NPC51146
Ingredient ID: NPC488346
Ingredient ID: NPC488345
Ingredient ID: NPC488344
Ingredient ID: NPC488343
Ingredient ID: NPC488342
Ingredient ID: NPC488341
Ingredient ID: NPC488340
Ingredient ID: NPC488339
Ingredient ID: NPC488338
Ingredient ID: NPC488337
Ingredient ID: NPC488336
Ingredient ID: NPC488335
Ingredient ID: NPC488334
Ingredient ID: NPC488333
Ingredient ID: NPC488332
Ingredient ID: NPC488331
Ingredient ID: NPC488330
Ingredient ID: NPC488329
Ingredient ID: NPC488328
Ingredient ID: NPC488327
Ingredient ID: NPC488326
Ingredient ID: NPC488325
Ingredient ID: NPC488324
Ingredient ID: NPC41499
Ingredient ID: NPC41400
Ingredient ID: NPC34770
Ingredient ID: NPC34485
Ingredient ID: NPC33320
Ingredient ID: NPC326489
Ingredient ID: NPC326093
Ingredient ID: NPC324424
Ingredient ID: NPC322498
Ingredient ID: NPC321965
Ingredient ID: NPC321166
Ingredient ID: NPC320858
Ingredient ID: NPC319343
Ingredient ID: NPC318459
Ingredient ID: NPC312146
Ingredient ID: NPC307412
Ingredient ID: NPC305648
Ingredient ID: NPC305208
Ingredient ID: NPC300299
Ingredient ID: NPC296663
Ingredient ID: NPC292370
Ingredient ID: NPC288089
Ingredient ID: NPC283810
Ingredient ID: NPC283331
Ingredient ID: NPC281931
Ingredient ID: NPC276761
Ingredient ID: NPC276207
Ingredient ID: NPC274909
Ingredient ID: NPC267801
Ingredient ID: NPC266743
Ingredient ID: NPC265547
Ingredient ID: NPC258750
Ingredient ID: NPC257188
Ingredient ID: NPC254876
Ingredient ID: NPC252256
Ingredient ID: NPC252223
Ingredient ID: NPC247553
Ingredient ID: NPC243062
Ingredient ID: NPC242517
Ingredient ID: NPC237186
Ingredient ID: NPC235682
Ingredient ID: NPC234536
Ingredient ID: NPC230199
Ingredient ID: NPC220241
Ingredient ID: NPC219564
Ingredient ID: NPC219104
Ingredient ID: NPC218109
Ingredient ID: NPC217903
Ingredient ID: NPC217829
Ingredient ID: NPC217176
Ingredient ID: NPC214309
Ingredient ID: NPC209959
Ingredient ID: NPC20082
Ingredient ID: NPC198816
Ingredient ID: NPC198160
Ingredient ID: NPC194502
Ingredient ID: NPC187058
Ingredient ID: NPC185541
Ingredient ID: NPC179605
Ingredient ID: NPC179037
Ingredient ID: NPC172784
Ingredient ID: NPC169
Ingredient ID: NPC168517
Ingredient ID: NPC16066
Ingredient ID: NPC158306
Ingredient ID: NPC153500
Ingredient ID: NPC147661
Ingredient ID: NPC144288
Ingredient ID: NPC141080
Ingredient ID: NPC141068
Ingredient ID: NPC139323
Ingredient ID: NPC131885
Ingredient ID: NPC131296
Ingredient ID: NPC12766
Ingredient ID: NPC116178
Ingredient ID: NPC110008
Ingredient ID: NPC109515
Ingredient ID: NPC103281
Ingredient ID: NPC102285
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A13 | Cytochrome P450 2A13 | Q16696 | CHEMBL3542436 |
| Drug Transporter | Voltage-gated sodium channel | SCN9A | Sodium channel protein type IX alpha subunit | Q15858 | CHEMBL4296 |
| Drug Transporter | Voltage-gated sodium channel | SCN1A | Sodium channel protein type I alpha subunit | P35498 | CHEMBL1845 |
| Drug Transporter | Voltage-gated sodium channel | SCN4A | Sodium channel protein type IV alpha subunit | P35499 | CHEMBL2072 |
| Drug Transporter | Voltage-gated sodium channel | SCN8A | Sodium channel protein type VIII alpha subunit | Q9UQD0 | CHEMBL5202 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 20 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00004359 | Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita | epidermolysis bullosa acquisita | Methoxsalen (NPC33320) | NP level |
| NCT00005092 | Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer | leukemia;multiple myeloma;myelodysplastic syndrome | Psoralen (NPC51146) | NP level |
| NCT00030589 | Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00054600 | Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00054613 | Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00056056 | Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00056355 | Extracorporeal Photopheresis to Maintain Symptoms Remission During Steroid Withdrawal in Patients With Steroid-Dependent Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
| NCT00221000 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis | rheumatoid arthritis | Methoxsalen (NPC33320) | NP level |
| NCT00221026 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
| NCT00282503 | Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease | acute graft vs. host disease | Methoxsalen (NPC33320) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
SCN5A
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SCN4A,CA9,ACHE,SCN5A,CA12,SCN8A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SCN5A,TUBB6,ACHE,CA9
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
SCN5A,SCN3A
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT00533195
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
SCN5A,CA12
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
SCN9A
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,CA9
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
SCN4A,SCN1A,TDP1,CA9,CYP2A13,SCN9A,SCN5A,SCN8A
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
