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Collective Molecular Activities of the Plant: Melia Indica


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO3846
Plant Latin Name: Melia Indica
Taxonomy Genus: Melia
Taxonomy Family: Meliaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:
China

Traditional Medicine System:
TCM

Geographical Distribution

China

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

40 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


18 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

12 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC9600

Ingredient ID: NPC62242

Ingredient ID: NPC61449

Ingredient ID: NPC53954

Ingredient ID: NPC52955

Ingredient ID: NPC5153

Ingredient ID: NPC42264

Ingredient ID: NPC301583

Ingredient ID: NPC299856

Ingredient ID: NPC286233

Ingredient ID: NPC26974

Ingredient ID: NPC259205

Ingredient ID: NPC253410

Ingredient ID: NPC240820

Ingredient ID: NPC238254

Ingredient ID: NPC223695

Ingredient ID: NPC218109

Ingredient ID: NPC209971

Ingredient ID: NPC208620

Ingredient ID: NPC202551

Ingredient ID: NPC197596

Ingredient ID: NPC196776

Ingredient ID: NPC179950

Ingredient ID: NPC179403

Ingredient ID: NPC17810

Ingredient ID: NPC175048

Ingredient ID: NPC174922

Ingredient ID: NPC173638

Ingredient ID: NPC16729

Ingredient ID: NPC163459

Ingredient ID: NPC159362

Ingredient ID: NPC157410

Ingredient ID: NPC155185

Ingredient ID: NPC153843

Ingredient ID: NPC149300

Ingredient ID: NPC133765

Ingredient ID: NPC133671

Ingredient ID: NPC12343

Ingredient ID: NPC120958

Ingredient ID: NPC116717

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 Cytochrome P450 family 5 TBXAS1 Thromboxane-A synthase P24557 CHEMBL1835
Therapeutic Target Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Therapeutic Target Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Therapeutic Target Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Therapeutic Target Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Therapeutic Target Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Therapeutic Target Protein Kinase MAPK14 MAP kinase p38 alpha Q16539 CHEMBL260
Therapeutic Target Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Therapeutic Target Protein Kinase LCK Tyrosine-protein kinase LCK P06239 CHEMBL258
Therapeutic Target Protein Kinase FYN Tyrosine-protein kinase FYN P06241 CHEMBL1841
Drug Transporter SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 Q9Y6L6 CHEMBL1697668
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level15
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT00000161 Randomized Trials of Vitamin Supplements and Eye Disease cataract;macular degeneration Beta Carotene (NPC17810) NP level
NCT02280759 Efficacy of Gelatin Tannate in Treatment Acute Gastroenteritis in Children. gastroenteritis Tannic Acid (NPC149300) NP level
NCT02446795 Isoquercetin as an Adjunct Therapy in Patients With Kidney Cancer Receiving First-line Sunitinib: a Phase I/II Trial renal cell carcinoma Isoquercetin (NPC179950) NP level
NCT04733651 Study to Investigate the Clinical Efficacy of Isoquercetin in Patients With COVID-19 COVID-19 Isoquercetin (NPC179950) NP level
NCT00000541 Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) myocardial infarction;Myocardial Ischemia Beta Carotene (NPC17810) NP level
NCT02647983 Multiparametric MRI for Prostate Cancer Localization and Characterization Using Hyperpolarized Pyruvate (13C) Injection prostate adenocarcinoma Pyruvate (NPC286233) NP level
NCT04514510 Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease sickle cell anemia Isoquercetin (NPC179950) NP level
NCT04622865 Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19 COVID-19 Isoquercetin (NPC179950) NP level
NCT02644200 Gelatin Tannate as Treatment for Acute Childhood Gastroenteritis gastroenteritis Tannic Acid (NPC149300) NP level
NCT00275418 Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease Crohn's disease Beta Carotene (NPC17810) NP level
NCT03121989 Study to Evaluate the Feasibility of 13-C Pyruvate Imaging in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy breast cancer Pyruvate (NPC286233) NP level
NCT04536090 Study of Isoquercetin (IQC-950AN) Plus Standard of Care Versus Standard of Care Only for the Treatment of COVID-19 COVID-19 Isoquercetin (NPC179950) NP level
NCT00000152 Randomized Trial of Beta-Carotene and Macular Degeneration macular degeneration Beta Carotene (NPC17810) NP level
NCT04474626 Isoquercetin in Sickle Cell Anemia sickle cell anemia Isoquercetin (NPC179950) NP level
NCT02552888 Nitrite, Isoquercetin and Endothelial Dysfunction (NICE) Trial chronic kidney disease Isoquercetin (NPC179950) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 MAPK1,FYN,CA4,LCK,KDM1A,CA12,CA2
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 CA7,KDM1A,TBXAS1,CA2,LCK
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 CYP1A2,TBXAS1,CA12,CA2,LCK
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 CA7,FYN,TBXAS1,CA2,LCK
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 MAPK1,SLCO1B1,CA4,TBXAS1,CA12
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 CA2,CA12,CA4
 NCT03121989
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 CA7,TBXAS1,CA12,LCK
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 CA4,CA12,L3MBTL1,CA12
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 TBXAS1,CA12,CA2,LCK
Seborrhoeic dermatitis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA81
 CA2,CA12,CA4
Myeloproliferative neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A20
 FYN,KDM1A,LCK
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 CA2,CA12,CA4
COVID-19
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D6Y
 NCT04622865,NCT04536090,NCT04733651
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 CA4,CA12,L3MBTL1
Squamous cell carcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.2
 CA7,SLCO1B1,CA12
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 CYP1A2,SLCO1B1,CA2
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 CA7,SLCO1B1,CA12
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 CYP1A2,CA12,CA2
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 CA12,CA4,CA7
Rheumatoid arthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA20
 MAPK14,CA2
Multiple myeloma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A83
 FYN,LCK
Postoperative inflammation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-CA43
 LCK,MAPK14
Glaucoma
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C61
 CA4,CA2
Myocardial infarction
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA41-BA43
 MAPK14
 NCT00000541
Asthma
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA23
 TBXAS1,CA4
Macular degeneration
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B75
 NCT00000152,NCT00000161
Sickle-cell disorder
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3A51
 NCT04514510,NCT04474626
Gastroenteritis or colitis without specification of origin
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A40.0
 NCT02280759,NCT02644200
Adenocarcinoma of prostate
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82.0
 SLCO1B1
 NCT02647983
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 CA4,CA2
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 CA4,L3MBTL1
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 LCK,TBXAS1
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 KDM1A,CA12
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 CA4,CA2
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 CA2,LCK
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 CA12,CA7
Angina pectoris
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA40
 TBXAS1
Heart failure
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD10-BD1Z
 CA2
Thrombosis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB61-GB90
 TBXAS1
Vitamin deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B55-5B5F
 MAPK14
Insomnia
Disease Category: 07.Sleep-wake disorders
Disease ICD-11 Code: 7A00-7A0Z
 CA2
Low bone mass disorder
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83
 CA2
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 MAPK14
Malignant haematopoietic neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B33
 KDM1A
Melanoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 MAPK1
Duodenal ulcer
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA63
 CA2
Essential hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00
 CA2
Arteries/arterioles disorder
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD52
 MAPK1
Intrathoracic organs injury
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NB32
 MAPK14
Myelodysplastic syndrome
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A37
 KDM1A
Chronic obstructive pulmonary disease
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA22
 MAPK14
Pancreatic cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10
 MAPK1
Coronary atherosclerosis
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA80
 MAPK14
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 KDM1A
Lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 KDM1A
Cardiovascular disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00-BE2Z
 LCK
Indeterminate colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD72
 TBXAS1
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 KDM1A
Ewing sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B52
 KDM1A
Type 2 diabetes mellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A11
 TBXAS1
Chronic kidney disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61
 NCT02552888
Crohn disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD70
 NCT00275418
Cataract
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B10
 NCT00000161
Ischaemic heart diseases, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA6Z
 NCT00000541
Renal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90
 NCT02446795
Osteoarthritis, unspecified
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA0Z
 CA12
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 SLCO1B1
Atrial fibrillation
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC81.3
 CA7
Malignant neoplasm metastasis in lymph nodes of head, face or neck
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60.0
 SLCO1B1
Keratoconus
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9A78.50
 CA4
Pre-eclampsia
Disease Category: 18.Pregnancy, childbirth or the puerperium
Disease ICD-11 Code: JA24
 CA4
Tetralogy of Fallot
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA88.2
 CA4
Other specified malignant neoplasms ofcolon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 SLCO1B1
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 TBXAS1
Other specified malignant neoplasms of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.Y
 CA12
Malignant neoplasms of oesophagus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 SLCO1B1
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 CA2
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 TBXAS1
Invasive carcinoma of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C61
 CA12
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 FYN

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
Prof. Chen Yu Zong
chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
dyhou22@m.fudan.edu.cn
Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
yhfeng22@m.fudan.edu.cn

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