CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Ferula Fukanensis

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO3780
Plant Latin Name: Ferula Fukanensis
Taxonomy Genus: Ferula
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 1271630
Plant-of-the-World-Online: n.a.

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

83 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

80 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

36 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC9880

Ingredient ID: NPC92133

Ingredient ID: NPC88603

Ingredient ID: NPC88566

Ingredient ID: NPC79550

Ingredient ID: NPC78551

Ingredient ID: NPC73078

Ingredient ID: NPC71853

Ingredient ID: NPC71703

Ingredient ID: NPC64176

Ingredient ID: NPC61828

Ingredient ID: NPC60556

Ingredient ID: NPC475955

Ingredient ID: NPC474726

Ingredient ID: NPC474542

Ingredient ID: NPC474289

Ingredient ID: NPC473977

Ingredient ID: NPC473976

Ingredient ID: NPC4297

Ingredient ID: NPC327612

Ingredient ID: NPC319879

Ingredient ID: NPC319870

Ingredient ID: NPC317045

Ingredient ID: NPC313039

Ingredient ID: NPC309182

Ingredient ID: NPC301964

Ingredient ID: NPC298596

Ingredient ID: NPC296337

Ingredient ID: NPC295474

Ingredient ID: NPC293804

Ingredient ID: NPC288932

Ingredient ID: NPC278821

Ingredient ID: NPC277907

Ingredient ID: NPC254529

Ingredient ID: NPC253963

Ingredient ID: NPC25293

Ingredient ID: NPC252152

Ingredient ID: NPC248726

Ingredient ID: NPC246177

Ingredient ID: NPC239039

Ingredient ID: NPC238253

Ingredient ID: NPC236641

Ingredient ID: NPC234231

Ingredient ID: NPC231738

Ingredient ID: NPC230475

Ingredient ID: NPC227670

Ingredient ID: NPC226259

Ingredient ID: NPC224666

Ingredient ID: NPC209275

Ingredient ID: NPC208361

Ingredient ID: NPC207844

Ingredient ID: NPC206284

Ingredient ID: NPC198658

Ingredient ID: NPC198459

Ingredient ID: NPC198249

Ingredient ID: NPC19488

Ingredient ID: NPC192962

Ingredient ID: NPC191498

Ingredient ID: NPC184207

Ingredient ID: NPC175987

Ingredient ID: NPC174006

Ingredient ID: NPC172260

Ingredient ID: NPC166362

Ingredient ID: NPC163895

Ingredient ID: NPC155182

Ingredient ID: NPC15074

Ingredient ID: NPC148738

Ingredient ID: NPC143436

Ingredient ID: NPC143208

Ingredient ID: NPC141777

Ingredient ID: NPC13991

Ingredient ID: NPC137201

Ingredient ID: NPC135648

Ingredient ID: NPC135388

Ingredient ID: NPC131043

Ingredient ID: NPC126173

Ingredient ID: NPC124161

Ingredient ID: NPC114239

Ingredient ID: NPC114011

Ingredient ID: NPC109813

Ingredient ID: NPC109812

Ingredient ID: NPC108494

Ingredient ID: NPC104569

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Therapeutic Target	Transcription factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096

Showing 1 to 2 of 2 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
No data available in table

Showing 0 to 0 of 0 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	TP53
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CNR2
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CNR2
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CNR2
Bladder cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	TP53
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	TP53
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	TP53
Cervical cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C77	TP53
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	TP53
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	TP53

Showing 1 to 10 of 43 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Ferula Fukanensis

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

83 All known Ingredients in Total

80 Ingredients with Acceptable Bioavailablity

36 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute myeloid leukaemia

Adenocarcinoma of pancreas

Atopic eczema

Attention deficit hyperactivity disorder

Bladder cancer

Brain cancer

Carcinosarcoma of uterus

Cervical cancer

Chronic arterial occlusive disease

Colorectal cancer

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities