Collective Molecular Activities of the Plant: Robinia Pseudoacacia
Plant ID: NPO3634
Plant Latin Name: Robinia Pseudoacacia
Taxonomy Genus: Robinia
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
35938
Plant-of-the-World-Online:
30034699-2
Country/Region:
Turkey; Italy; China; IndiaTraditional Medicine System:
TCMMedicinal Functions:
Antispasmodic; Antiviral; Aromatic; Cancer; Cholagogue; Diuretic; Emetic; Emollient; Febrifuge; Laxative; Narcotic; Purgative; Tonic
Turkey; Italy; Turkmenistan; France; Georgia; Argentina; Uzbekistan; Belarus; Algeria; China; Chile; Belgium; Germany; Iraq; Kazakhstan; Spain; Ukraine; Netherlands; Libya; United States; Morocco; Uruguay; Switzerland; New Zealand; Russia; Bulgaria; Pakistan; Romania; Albania; Mexico; South Africa; India; United Kingdom; Austria; Greece; Hungary; Taiwan; Tajikistan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
52 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
40 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9713
Ingredient ID: NPC95309
Ingredient ID: NPC74881
Ingredient ID: NPC70793
Ingredient ID: NPC69493
Ingredient ID: NPC56198
Ingredient ID: NPC54971
Ingredient ID: NPC53993
Ingredient ID: NPC42868
Ingredient ID: NPC329225
Ingredient ID: NPC325028
Ingredient ID: NPC32351
Ingredient ID: NPC318724
Ingredient ID: NPC311485
Ingredient ID: NPC304710
Ingredient ID: NPC302857
Ingredient ID: NPC281713
Ingredient ID: NPC279459
Ingredient ID: NPC278363
Ingredient ID: NPC272471
Ingredient ID: NPC269153
Ingredient ID: NPC26697
Ingredient ID: NPC261487
Ingredient ID: NPC259767
Ingredient ID: NPC259512
Ingredient ID: NPC256346
Ingredient ID: NPC244644
Ingredient ID: NPC235564
Ingredient ID: NPC231773
Ingredient ID: NPC231772
Ingredient ID: NPC214036
Ingredient ID: NPC197356
Ingredient ID: NPC19174
Ingredient ID: NPC18820
Ingredient ID: NPC186122
Ingredient ID: NPC183959
Ingredient ID: NPC173321
Ingredient ID: NPC163528
Ingredient ID: NPC162659
Ingredient ID: NPC160727
Ingredient ID: NPC155500
Ingredient ID: NPC151898
Ingredient ID: NPC148473
Ingredient ID: NPC140757
Ingredient ID: NPC138811
Ingredient ID: NPC134107
Ingredient ID: NPC1341
Ingredient ID: NPC120066
Ingredient ID: NPC11702
Ingredient ID: NPC116965
Ingredient ID: NPC115159
Ingredient ID: NPC110396
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 8 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00885599 | Efficacy of a Naturally-derived Mouthrinse for Gingival Inflammation | gingivitis | Thymol (NPC259512) | NP level |
| NCT01637948 | Controlled Clinical Trial of Traditional Chinese Medicine Mouthrinse | gingivitis | Thymol (NPC259512) | NP level |
| NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT02245204 | Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT02621060 | Effect of Chlorogenic Acid on Patients With Impaired Glucose Tolerance | abnormal glucose tolerance | Chlorogenic Acid (NPC302857) | NP level |
| NCT02728349 | Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
| NCT03751592 | Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer | lung cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT03758014 | Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients | glioblastoma multiforme | Chlorogenic Acid (NPC302857) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA,MAOB
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CDK8
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CA9,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,CA2,HIF1A,CA14,HSD17B2,CYP1B1,CA9,MAOB,CYP2C19,CA7
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAOA,MAOB,ESR2
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
