Plant ID: NPO3599
Plant Latin Name: Rheum Maximowiczii
Taxonomy Genus: Rheum
Taxonomy Family: Polygonaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Uzbekistan
Ingredient ID: NPC93074
Ingredient ID: NPC86412
Ingredient ID: NPC85265
Ingredient ID: NPC81853
Ingredient ID: NPC44555
Ingredient ID: NPC42813
Ingredient ID: NPC306232
Ingredient ID: NPC298328
Ingredient ID: NPC297796
Ingredient ID: NPC295217
Ingredient ID: NPC280254
Ingredient ID: NPC280141
Ingredient ID: NPC264375
Ingredient ID: NPC261117
Ingredient ID: NPC258501
Ingredient ID: NPC256154
Ingredient ID: NPC253747
Ingredient ID: NPC245787
Ingredient ID: NPC241911
Ingredient ID: NPC228850
Ingredient ID: NPC228822
Ingredient ID: NPC227360
Ingredient ID: NPC218267
Ingredient ID: NPC217922
Ingredient ID: NPC217691
Ingredient ID: NPC212223
Ingredient ID: NPC206800
Ingredient ID: NPC200321
Ingredient ID: NPC188169
Ingredient ID: NPC178952
Ingredient ID: NPC176066
Ingredient ID: NPC174167
Ingredient ID: NPC173368
Ingredient ID: NPC165792
Ingredient ID: NPC161293
Ingredient ID: NPC158663
Ingredient ID: NPC158020
Ingredient ID: NPC155674
Ingredient ID: NPC152440
Ingredient ID: NPC136699
Ingredient ID: NPC127026
Ingredient ID: NPC115067
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Therapeutic Target | Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Therapeutic Target | Protein Kinase | FYN | Tyrosine-protein kinase FYN | P06241 | CHEMBL1841 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 45 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00792714 | Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT03747679 | Palatability (Taste) of Oral Formulations of Bosutinib | chronic myelogenous leukemia | Mannitol (NPC86412) | NP level |
NCT00251056 | Mannitol Dose Response Study in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT04870073 | Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery | coronary artery disease | Mannitol (NPC86412) | NP level |
NCT04385264 | COVID-19 | Mannitol (NPC86412) | NP level | |
NCT01028339 | Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values | brain injury | Mannitol (NPC86412) | NP level |
NCT02861898 | Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma | brain cancer;glioblastoma multiforme | Mannitol (NPC86412) | NP level |
NCT00455130 | A Phase 2 Study to Determine the Safety and Efficacy of Inhaled Dry Powder Mannitol in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT01887197 | Repeatability and Response Study of Absorptive Clearance Scans | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT03573999 | Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation | brain edema | Mannitol (NPC86412) | NP level |
NCT00730977 | A Pilot Study to Investigate Administration of Mannitol Via a Novel Dry Powder Inhaler Device | Bronchiectasis | Mannitol (NPC86412) | NP level |
NCT01718964 | Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel) | opioid dependence | Mannitol (NPC86412) | NP level |
NCT01142505 | Wheeze and Intermittent Treatment | wheezing | Mannitol (NPC86412) | NP level |
NCT00113854 | Mannitol as Adjunct Therapy for Childhood Cerebral Malaria | malaria | Mannitol (NPC86412) | NP level |
NCT01233492 | Boron Phenylalanine With or Without Mannitol in Treating Patients With Glioblastoma Multiforme | Central Nervous System Neoplasm | Mannitol (NPC86412) | NP level |
NCT01843088 | Trial of Mannitol Cream for Pain Relief After a Long Run | pain | Mannitol (NPC86412) | NP level |
NCT05129748 | Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy | hearing loss | Mannitol (NPC86412) | NP level |
NCT04488874 | Sodium Lactate and Brain Relaxation (LSD) | intracranial hypertension | Mannitol (NPC86412) | NP level |
NCT04394143 | Effect of AD128 to Treat Obstructive Sleep Apnea | obstructive sleep apnea | Mannitol (NPC86412) | NP level |
NCT00810940 | Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury | injury | Mannitol (NPC86412) | NP level |
NCT00630812 | Long Term Administration of Inhaled Mannitol in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT03749408 | Effect of Addition of Mannitol to Bupivacaine on IANB Success and Post-endodontic Pain | pulpitis | Mannitol (NPC86412) | NP level |
NCT00277537 | Safety and Efficacy of Bronchitol in Bronchiectasis | Bronchiectasis | Mannitol (NPC86412) | NP level |
NCT02728687 | Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy | diabetic neuropathy | Mannitol (NPC86412) | NP level |
NCT00446680 | Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT00189007 | Antenatal Allopurinol During Fetal Hypoxia | fetal hypoxia | Mannitol (NPC86412) | NP level |
NCT01076491 | High Dose Inhaled Mannitol Study | Bronchiectasis | Mannitol (NPC86412) | NP level |
NCT01883531 | Crossover Trial Determining the Efficacy of Dry Powder Mannitol to Improve Lung Function in Subjects Aged 6-17 Years | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT00446667 | A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD | chronic obstructive pulmonary disease | Mannitol (NPC86412) | NP level |
NCT02484170 | Mannitol Cream for Post Herpetic Neuralgia | postherpetic neuralgia | Mannitol (NPC86412) | NP level |
NCT01485315 | Transfusion-requirements in Septic Shock Trial | septic shock | Mannitol (NPC86412) | NP level |
NCT02134353 | A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT04534465 | Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements. | Constipation | Mannitol (NPC86412) | NP level |
NCT00117208 | Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
NCT01520207 | Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension | hypotension | Mannitol (NPC86412) | NP level |
NCT00359697 | Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure | intracranial hypertension | Mannitol (NPC86412) | NP level |
NCT02570971 | Mannitol Versus Supportive Care in Ciguatera Fish Poisoning | ciguatera poisoning | Mannitol (NPC86412) | NP level |
NCT05305508 | Assessment of the Efficacy of Calcium Dobesilate vs. Placebo on SARS-CoV-2 Viral Load Amongst Outpatients With COVID-19. | COVID-19 | Mannitol (NPC86412) | NP level |
NCT01606787 | Mannitol Use During Partial Nephrectomy Prior to Renal Ischemia and Impact on Renal Function Outcomes | kidney cancer | Mannitol (NPC86412) | NP level |
NCT02037815 | Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy | brain edema | Mannitol (NPC86412) | NP level |
NCT00569088 | Study of the Pathogenesis and Molecular Mechanism of "YURE" in Internal Intractable Diseases | stroke | Mannitol (NPC86412) | NP level |
NCT03636971 | Gait Analysis Following Knee Viscosupplementation | osteoarthritis | Mannitol (NPC86412) | NP level |
NCT00303849 | Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors | anaplastic oligodendroglioma | Mannitol (NPC86412) | NP level |
NCT04217421 | Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass | congenital heart disease | Mannitol (NPC86412) | NP level |
NCT00669331 | Inhaled Mannitol as a Mucoactive Therapy for Bronchiectasis | Bronchiectasis | Mannitol (NPC86412) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT00630812,NCT00117208,NCT01883531,NCT00446680,NCT00455130,NCT00792714,NCT02134353,NCT00251056,NCT01887197
|
BronchiectasisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA24 |
NCT00277537,NCT00730977,NCT01076491,NCT00669331
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
FYN,CA2,CA6
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA2,HSD17B10,TDP1
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA6,CA2
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA2,CA6
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2,CA6
|
Other specified increased intracranial pressureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D60.Y |
NCT04488874,NCT00359697
|
Cerebral oedemaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D60.1 |
NCT02037815,NCT03573999
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04385264,NCT05305508
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA2,TDP1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HSD17B10,TDP1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
FYN,CA2
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CA6,CA2
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CA6,HSD17B10
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA2
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
FYN
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TNKS
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CA2
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
FYN
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
NCT01718964
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
NCT02861898
|
Intracranial injury, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.Z |
NCT01028339
|
Structural developmental anomaly of heart or great vessels, unspecifiedDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA8Z |
NCT04217421
|
Exposure to or harmful effects of undetermined intent of other or unspecified substances chiefly nonmedicinal as to sourceDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PH56 |
NCT02570971
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
NCT00569088
|
Obstructive sleep apnoeaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A41 |
NCT04394143
|
Maternal care for signs of fetal hypoxiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA86.2 |
NCT00189007
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT02861898
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT00446667
|
Postherpetic polyneuropathyDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E91.5 |
NCT02484170
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
NCT00113854
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT02728687
|
Chronic myeloid leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4XG8 |
NCT03747679
|
WheezingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.C |
NCT01142505
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT04534465
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT04870073
|
Hearing disorderDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AB50-AB57 |
NCT05129748
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT03636971
|
Oligodendroglioma, anaplasticDisease Category: X.Extension CodesDisease ICD-11 Code: XH8844 |
NCT00303849
|
HypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA20-BA21 |
NCT01520207
|
PulpitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA09.0 |
NCT03749408
|
Malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
NCT01606787
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
NCT00810940
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
NCT01233492
|
Septic shockDisease Category: X.Extension CodesDisease ICD-11 Code: XS26 |
NCT01485315
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT01843088
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA2
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
L3MBTL1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
L3MBTL1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CA6
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
CA6
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA6
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TDP1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CA6
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
L3MBTL1
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
CA2
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA2
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CA2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA6
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA2
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
FYN
|