Thailand; Myanmar; Cambodia
Ingredient ID: NPC96216
Ingredient ID: NPC94794
Ingredient ID: NPC57470
Ingredient ID: NPC474939
Ingredient ID: NPC471603
Ingredient ID: NPC470910
Ingredient ID: NPC470909
Ingredient ID: NPC470556
Ingredient ID: NPC470555
Ingredient ID: NPC470554
Ingredient ID: NPC470553
Ingredient ID: NPC470090
Ingredient ID: NPC36181
Ingredient ID: NPC33653
Ingredient ID: NPC307895
Ingredient ID: NPC294432
Ingredient ID: NPC289774
Ingredient ID: NPC285748
Ingredient ID: NPC249942
Ingredient ID: NPC221173
Ingredient ID: NPC138299
Ingredient ID: NPC118059
Ingredient ID: NPC112829
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
Therapeutic Target | Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
Therapeutic Target | Peptide receptor (family B GPCR) | GCGR | Glucagon receptor | P47871 | CHEMBL1985 |
Therapeutic Target | Protein Kinase | INSR | Insulin receptor | P06213 | CHEMBL1981 |
Therapeutic Target | Protein Kinase | FER | Tyrosine-protein kinase FER | P16591 | CHEMBL3982 |
Therapeutic Target | Protein Kinase | FLT1 | Vascular endothelial growth factor receptor 1 | P17948 | CHEMBL1868 |
Therapeutic Target | Protein Kinase | CSNK1D | Casein kinase I delta | P48730 | CHEMBL2828 |
Therapeutic Target | Protein Kinase | CLK4 | Dual specificity protein kinase CLK4 | Q9HAZ1 | CHEMBL4203 |
Therapeutic Target | Protein Kinase | PLK4 | Serine/threonine-protein kinase PLK4 | O00444 | CHEMBL3788 |
Therapeutic Target | Protein Kinase | RPS6KB1 | Ribosomal protein S6 kinase 1 | P23443 | CHEMBL4501 |
Therapeutic Target | Protein Kinase | STK3 | Serine/threonine-protein kinase MST2 | Q13188 | CHEMBL4708 |
Therapeutic Target | Protein Kinase | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Q12851 | CHEMBL5330 |
Therapeutic Target | Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
Therapeutic Target | Protein Kinase | JAK3 | Tyrosine-protein kinase JAK3 | P52333 | CHEMBL2148 |
Therapeutic Target | Protein Kinase | CLK2 | Dual specificity protein kinase CLK2 | P49760 | CHEMBL4225 |
Therapeutic Target | Protein Kinase | CSNK1A1 | Casein kinase I alpha | P48729 | CHEMBL2793 |
Therapeutic Target | Protein Kinase | MATK | Tyrosine-protein kinase CTK | P42679 | CHEMBL4175 |
Therapeutic Target | Protein Kinase | RET | Tyrosine-protein kinase receptor RET | P07949 | CHEMBL2041 |
Therapeutic Target | Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
Therapeutic Target | Protein Kinase | NTRK2 | Neurotrophic tyrosine kinase receptor type 2 | Q16620 | CHEMBL4898 |
Therapeutic Target | Protein Kinase | BLK | Tyrosine-protein kinase BLK | P51451 | CHEMBL2250 |
Therapeutic Target | Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
Therapeutic Target | Protein Kinase | BRSK1 | BR serine/threonine-protein kinase 1 | Q8TDC3 | CHEMBL5650 |
Therapeutic Target | Protein Kinase | PIM3 | Serine/threonine-protein kinase PIM3 | Q86V86 | CHEMBL5407 |
Therapeutic Target | Protein Kinase | MAPK10 | c-Jun N-terminal kinase 3 | P53779 | CHEMBL2637 |
Therapeutic Target | Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
Therapeutic Target | Protein Kinase | MAP3K20 | Mixed lineage kinase 7 | Q9NYL2 | CHEMBL3886 |
Therapeutic Target | Protein Kinase | FES | Tyrosine-protein kinase FES | P07332 | CHEMBL5455 |
Therapeutic Target | Protein Kinase | PHKG2 | Phosphorylase kinase gamma subunit 2 | P15735 | CHEMBL2349 |
Therapeutic Target | Protein Kinase | SGK2 | Serine/threonine-protein kinase Sgk2 | Q9HBY8 | CHEMBL5794 |
Therapeutic Target | Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
Therapeutic Target | Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
Therapeutic Target | Protein Kinase | DYRK3 | Dual-specificity tyrosine-phosphorylation regulated kinase 3 | O43781 | CHEMBL4575 |
Therapeutic Target | Protein Kinase | DAPK3 | Death-associated protein kinase 3 | O43293 | CHEMBL2468 |
Therapeutic Target | Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
Therapeutic Target | Protein Kinase | HIPK2 | Homeodomain-interacting protein kinase 2 | Q9H2X6 | CHEMBL4576 |
Therapeutic Target | Protein Kinase | MAPK14 | MAP kinase p38 alpha | Q16539 | CHEMBL260 |
Therapeutic Target | Protein Kinase | FGFR1 | Fibroblast growth factor receptor 1 | P11362 | CHEMBL3650 |
Therapeutic Target | Protein Kinase | FRK | Tyrosine-protein kinase FRK | P42685 | CHEMBL4223 |
Therapeutic Target | Protein Kinase | FLT4 | Vascular endothelial growth factor receptor 3 | P35916 | CHEMBL1955 |
Therapeutic Target | Protein Kinase | MAPK9 | c-Jun N-terminal kinase 2 | P45984 | CHEMBL4179 |
Therapeutic Target | Protein Kinase | CHEK2 | Serine/threonine-protein kinase Chk2 | O96017 | CHEMBL2527 |
Therapeutic Target | Protein Kinase | CDK2 | Cyclin-dependent kinase 2 | P24941 | CHEMBL301 |
Therapeutic Target | Protein Kinase | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | O95819 | CHEMBL6166 |
Therapeutic Target | Protein Kinase | PDPK1 | 3-phosphoinositide dependent protein kinase-1 | O15530 | CHEMBL2534 |
Therapeutic Target | Protein Kinase | MINK1 | Misshapen-like kinase 1 | Q8N4C8 | CHEMBL5518 |
Therapeutic Target | Protein Kinase | PIM2 | Serine/threonine-protein kinase PIM2 | Q9P1W9 | CHEMBL4523 |
Therapeutic Target | Protein Kinase | MARK3 | Serine/threonine-protein kinase c-TAK1 | P27448 | CHEMBL5600 |
Therapeutic Target | Protein Kinase | MAPK8 | c-Jun N-terminal kinase 1 | P45983 | CHEMBL2276 |
Therapeutic Target | Protein Kinase | PRKCG | Protein kinase C gamma | P05129 | CHEMBL2938 |
Therapeutic Target | Protein Kinase | IRAK4 | Interleukin-1 receptor-associated kinase 4 | Q9NWZ3 | CHEMBL3778 |
Therapeutic Target | Protein Kinase | MAPK11 | MAP kinase p38 beta | Q15759 | CHEMBL3961 |
Therapeutic Target | Protein Kinase | MKNK2 | MAP kinase signal-integrating kinase 2 | Q9HBH9 | CHEMBL4204 |
Therapeutic Target | Protein Kinase | PRKD3 | Protein kinase C nu | O94806 | CHEMBL2595 |
Therapeutic Target | Protein Kinase | PRKD2 | Serine/threonine-protein kinase D2 | Q9BZL6 | CHEMBL4900 |
Therapeutic Target | Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
Therapeutic Target | Protein Kinase | STK17A | Serine/threonine-protein kinase 17A | Q9UEE5 | CHEMBL4525 |
Therapeutic Target | Protein Kinase | MELK | Maternal embryonic leucine zipper kinase | Q14680 | CHEMBL4578 |
Therapeutic Target | Protein Kinase | RPS6KA3 | Ribosomal protein S6 kinase alpha 3 | P51812 | CHEMBL2345 |
Therapeutic Target | Protein Kinase | NTRK3 | NT-3 growth factor receptor | Q16288 | CHEMBL5608 |
Therapeutic Target | Protein Kinase | FGFR3 | Fibroblast growth factor receptor 3 | P22607 | CHEMBL2742 |
Therapeutic Target | Protein Kinase | CSF1R | Macrophage colony stimulating factor receptor | P07333 | CHEMBL1844 |
Therapeutic Target | Protein Kinase | SYK | Tyrosine-protein kinase SYK | P43405 | CHEMBL2599 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MELK,PIM1,FGFR1,GSK3B,SYK,MAPT,FLT3,PRKCG,AURKB
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
CDK1,CDK2,FLT4,FLT3,RET,KDR,MET,FGFR1,ALOX5
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
CSF1R,BLK,MATK,LYN,PIM2,FLT3,SYK,JAK3,PRKCG
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDC7,MELK,PBK,PLK4,TTK,AURKB,MET,CDK1,PRKCG
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
CDC7,MELK,PBK,TTK,MAPK12,CHEK2,AURKB,PLK4,CDK1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CDC7,MELK,PBK,TTK,CYP1A2,CYP3A4,AURKB,PLK4,CDK1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
FGFR3,GCGR,TYRO3,RET,ALOX5,BRSK1,GABRA6,NTRK3,MET
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
PRKD2,DYRK3,CSF1R,LMNA,IRAK4,KDR,LYN,SYK,MET
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
MAPK14,ALOX5,JAK3,MAPK12,OPRD1,MAPK11,CAMK2D,SYK
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
FGFR3,KDR,FLT1,PIM2,FLT3,FGFR1,INSR,RET
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
CSF1R,FES,TYRO3,BLK,STK17A,MATK,MAPK12,JAK3
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
KDR,SYK,RET,MAPK12,FGFR1,ALOX5,FLT1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
CSNK2A1,FLT4,FGFR3,MET,KDR,FGFR1,MKNK2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
MELK,PBK,TTK,CYP1A2,CYP3A4,AURKB,MET
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
CDK2,BLK,RET,NTRK2,CHEK2,LYN,SYK
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FLT3,ALOX5,MAPK8,MAPK10,FGFR1,MAPK9
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FLT1,MET,CSF1R,FGFR1,KDR,FLT4
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
MAPK10,FGFR1,MAPK8,MAPK9,INSR,GCGR
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
MELK,PBK,CSF1R,TTK,PLK4,CDK1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
FLT4,RET,LYN,FLT1,MET,JAK3
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
PBK,MELK,TTK,AURKB,PLK4,CDK1
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
TYRO3,LMNA,NTRK2,PIM2,NTRK3,PIM3
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
FGFR1,DYRK3,BLK,RET,LYN,PRKCG
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
FLT1,MELK,FGFR1,KDR,RET
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,INSR,GCGR,FGFR1,KDR
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
FLT1,MET,FGFR3,KDR,FLT4
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4,ALOX5,SYK,SYK,JAK3
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
FGFR3,FLT3,MELK,FGFR1,GSK3B
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CDK2,PDPK1,IRAK4,MKNK2,SYK
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KDR,NTRK2,MET,CDK2,NTRK3
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
CDK2,INSR,TYRO3,LMNA,MAPK12
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
FLT1,NTRK3,FLT3,SYK,MET
|
Cutaneous lupus erythematosusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB50-EB5Z |
MAPK9,MAPK8,MAPK10,SYK
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
FLT3,MARK3,FGFR1,KDR
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
OPRD1,MAPK12,INSR,ALOX5
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
MELK,RET,CDK1,FLT3
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
MET,KDR,FGFR1,FLT3
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
IRAK4,JAK3,FLT3,ALOX5
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
PBK,MELK,TTK,CDK1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
OPRD1,TYRO3,MET,PRKCG
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CSNK2A1,CHEK2,CSNK1A1,TTK,ALOX5,FGFR3,NTRK3,CYP3A4,PIM1,CDK1,MAPK10,FLT3,RPS6KB1,MARK3,FLT1,TYRO3,CDK2,KDR,CDC7,CSF1R,SYK,MAPK8,MET,NTRK2,MKNK2,FGFR1,AURKB,GSK3B,LYN,PIM2,MAPK9,FLT4,RET
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
MAPK9,NTRK2,MAPK10,AURKB,CSNK2A1,CAMK2D,MAPK11,NEK4,CDC7,FGFR1,CHEK2,FER,FRK,PLK4,PRKD3,CDK5,CDK2,MELK,DYRK3,BLK,LMNA,BRSK1,TTK,FLT1,MET,CDK1,PBK,TYRO3,KDR,RPS6KB1,MAPK12,PIM2,NTRK3
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
OPRD1,AURKB,PRKD2,CDC7,CSF1R,ALOX5,CHEK2,SYK,PLK4,PRKCG,CDK5,CDK2,MELK,CSNK1G3,BLK,RET,PHKG2,PIM1,TTK,LMNA,LYN,FLT3,MET,JAK3,CDK1,PBK,TYRO3,KDR,PIM2,MAP4K4
|
Dissociative neurological symptom disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B60 |
MAPK9,MAPK10,MAPK8
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
MET,KDR,CDK2
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
FGFR1,FGFR3,MAPK14
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
MET,KDR,RET
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
MET,FLT1,FLT1
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
CDK2,CDK1,ALOX5
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
GCGR,CSF1R,INSR
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
OPRD1,KDR,FLT3
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FGFR1,FGFR3,FLT1
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
BRSK1,SGK2,PIM1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
MELK,AURKB,PRKCG
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CLK2,MAPK10,AURKB,CSNK2A1,MAPK11,DAPK3,PRKD2,FGFR1,CDC7,MINK1,ALOX5,STK17A,FER,SYK,PLK4,PRKCG,MELK,LMNA,BRSK1,TTK,MAPT,JAK3,CDK1,FGFR3,PBK,TYRO3,MAPK12
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CSNK1A1,AURKB,CYP2C19,CAMK2D,CSF1R,ALOX5,CHEK2,SYK,PLK4,PRKCG,CDK5,MELK,BLK,LMNA,PIM1,TTK,LYN,MET,JAK3,PBK,MATK,PIM2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
GCGR,OPRD1,FES,HIPK2,PRKD2,FGFR1,CSF1R,ALOX5,RPS6KA3,CDK2,MELK,BLK,RET,MET,JAK3,CDK1,FGFR3,KDR,RPS6KB1,MATK,MAPK12,MAP4K4
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
OPRD1,AURKB,ALOX5,CHEK2,PRKCG,MELK,BRSK1,TTK,MET,JAK3,PBK,MELK,OPRD1,PBK,ALOX5,CSF1R,TTK,MATK,FLT1,AURKB,JAK3
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CDC7,MELK,PBK,TYRO3,BRSK1,TTK,MAPT,MAPK12,AURKB,PLK4,CDK1,MAPK11,MELK,PBK,TTK,MAPT,MAPK12,AURKB,MAP4K4,PLK4,CDK1
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
KDR,MET
|
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
MET,KDR
|
B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A86 |
SYK,JAK3
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
SYK,JAK3
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
NTRK2,NTRK3
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FLT3,SYK
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
INSR,JAK3
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
KDR,MET
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
KDR,MET
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAPT,GSK3B
|
Phakomatoses/hamartoneoplastic syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2D |
FLT3,CSF1R
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
MAPK14,ALOX5
|
Bone/articular cartilage neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7B |
CSF1R,FLT3
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
PRKCG,FLT3
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
SYK,MELK
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
JAK3,ALOX5
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
CSF1R,FLT1
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4,OPRD1
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
FGFR1,FGFR3
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
FGFR3,MAPK14
|
MastocytosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A21 |
PRKCG,FLT3
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
FLT3,CSF1R
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
KDR,MET
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
FLT4,AURKB
|
Intrauterine growth restrictionDisease Category: 19.Certain conditions originating in the perinatal periodDisease ICD-11 Code: KA20.1 |
FLT1,NTRK2
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
FLT1,NTRK2
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
FGFR3,PIM3
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
MELK,PRKCG
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
MET,MAPK10
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
GCGR,OPRD1,AURKB,CDC7,CHEK2,SYK,PLK4,PRKCG,CDK5,MELK,RET,LYN,MET,JAK3,FGFR3,PBK,MATK,PIM2,MAP4K4
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
GCGR,OPRD1,CSNK2A1,HIPK2,CDC7,CSF1R,ALOX5,FRK,PLK4,PRKCG,BLK,RET,LYN,MET,FGFR3,MATK,CYP1A2,PIM2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
FLT4,CSF1R,MAPK12,NTRK2,FGFR3,MET,MAPK11,KDR,FLT3,INSR,MAPK14,NTRK3,FLT1,MAPT,FGFR1
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
GCGR,OPRD1,NTRK2,MAPK11,FGFR1,PRKCG,RET,BRSK1,MAPT,LYN,FLT1,MET,PBK,PIM2,NTRK3
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
FGFR3,GCGR,CDC7,FLT4,OPRD1,BLK,RET,BRSK1,MATK,LYN,SGK2,PIM3,SYK,CYP2C19,PRKCG
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
FGFR3,CDC7,CSF1R,BRSK1,STK17A,MATK,CHEK2,PIM2,MAPT,CYP3A4,FLT3,SYK,FRK,PRKCG,CDK5
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
MKNK2,CDK2,CDK1,MELK,FGFR1,FLT4,RET,NTRK2,MET,KDR,NTRK3,PLK4,FGFR3,MAP4K2
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
FGFR1,MELK,CDC7,OPRD1,TYRO3,PBK,BRSK1,TTK,FER,MAP4K4,AURKB,PLK4,CDK1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
FGFR3,GCGR,MELK,CDC7,PBK,NTRK2,TTK,MAPK12,CHEK2,AURKB,PLK4,CDK1,PRKCG
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
GCGR,MELK,OPRD1,PBK,RET,TTK,CHEK2,SGK2,AURKB,PLK4,CDK1,PRKCG,CYP2D6
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FGFR1,MELK,PBK,PLK4,PRKACA,TTK,MATK,PIM2,CYP3A4,AURKB,MET,CDK1,JAK3
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
FGFR3,GCGR,MELK,CDC7,OPRD1,BLK,RET,PBK,TTK,AURKB,PLK4,CDK1
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
CDK2,CSNK1A1,CDC7,SYK,CLK2,CLK4,CSF1R,FLT3,AURKB,CDK1,JAK3
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NTRK3,FLT3,MKNK2,RET,PRKCG,NTRK2,MET,FGFR1,FLT1,KDR
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
GCGR,MELK,CDC7,PBK,TTK,SGK2,AURKB,PLK4,CDK1,CYP2D6
|
Intrathoracic organs injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NB32 |
MAPK14
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
MAPK12
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
GCGR
|
NADisease Category: NADisease ICD-11 Code: NA |
MET
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
RET
|
Circulatory system diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BE2Z |
FLT4
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
OPRD1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
RET
|
PruritusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC90 |
JAK3
|
Pancreatic internal secretion disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A4Y |
GCGR
|
Biliary tract cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C17 |
MET
|
Skeletal anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD24 |
FGFR3
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CYP2D6
|
Liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB90-DB9Z |
MET
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
FLT1
|
Type-1/2 diabeteDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10-5A11 |
INSR
|
AlopeciaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED70 |
JAK3
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
MET
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
FLT3
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
MET
|
Spinal painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84 |
OPRD1
|
Coronavirus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D92 |
CSNK2A1
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
FLT3
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
CardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43 |
MAPK12
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
MAPK12
|
Vitamin deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B55-5B5F |
MAPK14
|
Ischemic heart diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40-BA6Z |
MET
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
FGFR1
|
Malignant digestive organ neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C11 |
KDR
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
OPRD1
|
Coronary vasospastic diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA85 |
OPRD1
|
Digestive organ benign neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E92 |
KDR
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
INSR
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
OPRD1
|
OsteosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B51 |
GSK3B
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ALOX5
|
Musculoskeletal system/connective tissue diseaseDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FC0Z |
LYN
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT
|
Transplanted organ/tissueDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QB63 |
FLT3
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
CSF1R
|
UrticariaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB00-EB05 |
SYK
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
GSK3B
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
CYP2D6
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
KDR
|
Hypo-glycaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A41 |
GCGR
|
Epidermal dysplasiasDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK90 |
FGFR1
|
Lysosomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C56 |
INSR
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
MAPK12
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
ALOX5
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
FLT3
|
Bowel habit changeDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05 |
OPRD1
|
Functional bladder disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC50 |
OPRD1
|
Ureteral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C92 |
FGFR3
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
MAPK14
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
OPRD1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
ALOX5
|
Myotonic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71 |
GSK3B
|
ThymomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CDK2
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
FLT1
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
PIM2
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
JAK3
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
AURKB
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
PIM2
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
RET
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
MATK
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CSF1R
|
Other specified diseases of the nervous systemDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E7Y |
HIPK2
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
MATK
|
Dilated cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.0 |
HIPK2
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MET
|