Collective Molecular Activities of the Plant: Karwinskia Parvifolia
Plant ID: NPO3206
Plant Latin Name: Karwinskia Parvifolia
Taxonomy Genus: Karwinskia
Taxonomy Family: Rhamnaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
8 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
5 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
6 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC90408
Ingredient ID: NPC472262
Ingredient ID: NPC472261
Ingredient ID: NPC30324
Ingredient ID: NPC296752
Ingredient ID: NPC230660
Ingredient ID: NPC197087
Ingredient ID: NPC1268
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 51 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00003170 | Glutamine in Preventing Acute Diarrhea in Patients With Pelvic Cancer | cancer | Glutamine (NPC197087) | NP level |
| NCT00003898 | Glutamine in Treating Side Effects in Children Who Are Undergoing Stem Cell Transplantation | neoplasm | Glutamine (NPC197087) | NP level |
| NCT00005775 | Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants | fetal growth restriction;premature birth;Sepsis | Glutamine (NPC197087) | NP level |
| NCT00006994 | S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat | oral mucositis | Glutamine (NPC197087) | NP level |
| NCT00010634 | Complementary Naturopathic Medicine for Periodontitis | periodontitis | Glutamine (NPC197087) | NP level |
| NCT00016653 | Creatine and Glutamine in Steroid-Naive Duchenne Muscular Dystrophy | Duchenne muscular dystrophy | Glutamine (NPC197087) | NP level |
| NCT00018109 | A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD) | Duchenne muscular dystrophy | Glutamine (NPC197087) | NP level |
| NCT00125788 | L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia | Thalassemia;sickle cell anemia | Glutamine (NPC197087) | NP level |
| NCT00131508 | Trial of Oral Glutamine in Patients With Sickle Cell Anemia | sickle cell anemia | Glutamine (NPC197087) | NP level |
| NCT00133406 | Long-term Impact and Intervention for Diarrhea in Brazil | diarrheal disease | Glutamine (NPC197087) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT04634539
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT04019769
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT02012608
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT01353638
|
Classical organic aciduriaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50.E0 |
NCT00645879
|
Clostridium difficile enterocolitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A04 |
NCT02053350
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT01087658
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
