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Collective Molecular Activities of the Plant: Stephania Cepharantha


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO31374
Plant Latin Name: Stephania Cepharantha
Taxonomy Genus: Stephania
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 152367
Plant-of-the-World-Online: 581404-1

Used in Medicines

Country/Region:
China

Traditional Medicine System:
TCM

Geographical Distribution

Taiwan; Vietnam; China

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

39 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


21 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

22 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC931

Ingredient ID: NPC8628

Ingredient ID: NPC82529

Ingredient ID: NPC73492

Ingredient ID: NPC66535

Ingredient ID: NPC4925

Ingredient ID: NPC49075

Ingredient ID: NPC485712

Ingredient ID: NPC485711

Ingredient ID: NPC485710

Ingredient ID: NPC485709

Ingredient ID: NPC485708

Ingredient ID: NPC485707

Ingredient ID: NPC39652

Ingredient ID: NPC328423

Ingredient ID: NPC326152

Ingredient ID: NPC321257

Ingredient ID: NPC319632

Ingredient ID: NPC317727

Ingredient ID: NPC317145

Ingredient ID: NPC299990

Ingredient ID: NPC289930

Ingredient ID: NPC278642

Ingredient ID: NPC276149

Ingredient ID: NPC271013

Ingredient ID: NPC270908

Ingredient ID: NPC26745

Ingredient ID: NPC257084

Ingredient ID: NPC248109

Ingredient ID: NPC24260

Ingredient ID: NPC222561

Ingredient ID: NPC2073

Ingredient ID: NPC195268

Ingredient ID: NPC183485

Ingredient ID: NPC159377

Ingredient ID: NPC157340

Ingredient ID: NPC135523

Ingredient ID: NPC133140

Ingredient ID: NPC10908

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Therapeutic Target Enzyme BLM Bloom syndrome protein P54132 CHEMBL1293237
Therapeutic Target Other cytosolic protein MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Therapeutic Target Phosphodiesterase 10 PDE10A Phosphodiesterase 10A Q9Y233 CHEMBL4409
Therapeutic Target Phosphodiesterase 3 PDE3A Phosphodiesterase 3A Q14432 CHEMBL241
Therapeutic Target Structural protein LMNA Prelamin-A/C P02545 CHEMBL1293235
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level131
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT02564978 Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration age-related macular degeneration Minocycline (NPC317727) NP level
NCT00619203 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis bacterial meningitis Glycerin (NPC157340) NP level
NCT00080808 Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer prostate cancer Papaverine (NPC195268) NP level
NCT00371332 Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis periodontitis Minocycline (NPC317727) NP level
NCT01468831 Minocycline to Treat Branch Retinal Vein Occlusion retinal vein occlusion Minocycline (NPC317727) NP level
NCT00691197 Safety and Acceptability of Using a Rewetting Drop With Contact Lens Wear Abnormality of refraction Glycerin (NPC157340) NP level
NCT01283997 Prevention of Treatment Induced Neuropathy in Multiple Myeloma multiple myeloma Minocycline (NPC317727) NP level
NCT01517334 Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation) Peri-Implantitis Minocycline (NPC317727) NP level
NCT02928965 The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms schizophrenia Minocycline (NPC317727) NP level
NCT00630942 Minocycline in Primary Sclerosing Cholangitis (PSC) sclerosing cholangitis Minocycline (NPC317727) NP level
NCT02133885 Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients hypertension Minocycline (NPC317727) NP level
NCT02815267 A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne acne Minocycline (NPC317727) NP level
NCT03489629 STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) cystic fibrosis Minocycline (NPC317727) NP level
NCT01687218 Safety and Acceptability Study of Oral Emtricitabine/Tenofovir Disoproxil Fumarate Tablet and Rectally-Applied Tenofovir Reduced-Glycerin 1% Gel HIV infection Glycerin (NPC157340) NP level
NCT03050086 Open Label Phase 2 Feasibility Study of BPX-04 Topical Minocycline Gel in Rosacea rosacea Minocycline (NPC317727) NP level
NCT01362010 Clinical Study to Evaluate Tolerability and Safety of FXFM244 and to Monitor Clinical Effect in Acne Vulgaris Patients acne Minocycline (NPC317727) NP level
NCT01575418 An Exploratory Rectal Safety Study of Three Tenofovir Gel Formulations HIV infection Glycerin (NPC157340) NP level
NCT00361257 Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults HIV infection Minocycline (NPC317727) NP level
NCT01805895 A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients intracerebral hemorrhage Minocycline (NPC317727) NP level
NCT00630396 Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke stroke Minocycline (NPC317727) NP level
NCT00515255 Study of NPL-2003 in Adolescents With Obsessive Compulsive Disorder (OCD) obsessive-compulsive disorder Minocycline (NPC317727) NP level
NCT01335386 Investigation of KLYX in Patients With Constipation Constipation Glycerin (NPC157340) NP level
NCT00203112 Safety and Efficacy Study of Copaxone Administered in Combination With Minocycline multiple sclerosis Minocycline (NPC317727) NP level
NCT00003667 Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma sarcoma Glycerin (NPC157340) NP level
NCT02056665 Study to Evaluate the Efficacy and Safety of Minocycline in Angelman Syndrome Angelman syndrome Minocycline (NPC317727) NP level
NCT01058395 Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) brain injury Minocycline (NPC317727) NP level
NCT00063193 National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial Parkinson disease Minocycline (NPC317727) NP level
NCT01746043 A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer esophageal cancer Minocycline (NPC317727) NP level
NCT02055963 Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer head and neck malignant neoplasia Minocycline (NPC317727) NP level
NCT02533232 Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia schizoaffective disorder;schizophrenia Minocycline (NPC317727) NP level
NCT01403662 Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression bipolar disorder;depressive disorder Minocycline (NPC317727) NP level
NCT02680379 Combined Treatment of Minocycline and Lovastatin to Treat Individuals With Fragile X Syndrome fragile X syndrome Minocycline (NPC317727) NP level
NCT03263273 Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea rosacea Minocycline (NPC317727) NP level
NCT04478500 Neuroinflammation in Hypertension Study hypertension Minocycline (NPC317727) NP level
NCT02695446 Administration of Oral Extended Release Minocycline for Assessment of Skin and Plasma Concentrations of Minocycline acne Minocycline (NPC317727) NP level
NCT01580969 Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma central nervous system cancer Minocycline (NPC317727) NP level
NCT02362529 Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder major depressive disorder Minocycline (NPC317727) NP level
NCT02099240 Patients Response to Early Switch To Oral:Osteomyelitis Study osteomyelitis Minocycline (NPC317727) NP level
NCT02187211 Minocycline's Effects on Alcohol Responses in Humans alcohol dependence Minocycline (NPC317727) NP level
NCT03947827 Minocycline as Adjunctive Treatment for Treatment Resistant Depression treatment resistant depression Minocycline (NPC317727) NP level
NCT05136846 Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer non-small cell lung carcinoma Papaverine (NPC195268) NP level
NCT03320018 Neuroprotection in Acute Ischemic Stroke stroke Minocycline (NPC317727) NP level
NCT01314482 Minocycline for the Prevention of Post-operative Intercostal Neuralgia neuralgia Minocycline (NPC317727) NP level
NCT03824327 Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases non-small cell lung carcinoma Papaverine Hydrochloride (NPC133140) NP level
NCT00916461 Role of Minocycline in First Episode Psychosis psychosis Minocycline (NPC317727) NP level
NCT00355576 Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis Minocycline (NPC317727) NP level
NCT01575405 A Study to Compare Three Different Formulations of Tenofovir 1% Gel When Administered Rectally HIV infection Glycerin (NPC157340) NP level
NCT02213575 Study 3: Minocycline Decreases Microglia Activation hypertension Minocycline (NPC317727) NP level
NCT02815280 A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne acne Minocycline (NPC317727) NP level
NCT00392223 Efficacy And Safety Of Azithromycin SR Compared With Minocycline In Acne acne Minocycline (NPC317727) NP level
NCT01219673 Symptom Burden in Head and Neck Cancer head and neck malignant neoplasia Minocycline (NPC317727) NP level
NCT01809340 The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression depressive disorder Minocycline (NPC317727) NP level
NCT00277355 Pilot Study of Minocycline in Huntington's Disease Huntington disease Minocycline (NPC317727) NP level
NCT01539564 Arestin - Use in Subjects With Peri-Implantitis Peri-Implantitis Minocycline (NPC317727) NP level
NCT01134627 Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS] relapsing-remitting multiple sclerosis Minocycline (NPC317727) NP level
NCT01134991 Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Rosacea Patients rosacea Minocycline (NPC317727) NP level
NCT02907437 Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia schizophrenia Minocycline (NPC317727) NP level
NCT04068207 Minocycline Treatment in Retinitis Pigmentosa retinitis pigmentosa Minocycline (NPC317727) NP level
NCT02998151 Neurophysiological and Acute Pharmacological Studies in FXS Patients fragile X syndrome Minocycline (NPC317727) NP level
NCT02113176 Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage hemorrhage Minocycline (NPC317727) NP level
NCT05398705 Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19 COVID-19 Cepharanthine (NPC73492) NP level
NCT02711241 Optimal Analgesia in Acute Gastroenteritis gastroenteritis Papaverine (NPC195268) NP level
NCT00203697 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study idiopathic pulmonary fibrosis Minocycline (NPC317727) NP level
NCT04031755 A Proof-of-Concept Study of Minocycline in Autism autism Minocycline (NPC317727) NP level
NCT01938508 Minocycline Bioequivalence Study skin disease Minocycline (NPC317727) NP level
NCT02936830 Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity allergic disease Glycerin (NPC157340) NP level
NCT01906008 Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients colorectal carcinoma Minocycline (NPC317727) NP level
NCT00243711 A Multi-Center Randomized Study to Evaluate the Efficacy and Safety of an Investigational Lubricant Eye Drop dry eye syndrome Glycerin (NPC157340) NP level
NCT01429272 Minocycline and Aspirin in the Treatment of Bipolar Depression bipolar disorder Minocycline (NPC317727) NP level
NCT00662532 Antibiotic Study for Dental Implants periodontitis Minocycline (NPC317727) NP level
NCT02456948 Adjunct Minocyline in Treatment-resistant Depression major depressive disorder Minocycline (NPC317727) NP level
NCT02272270 Phase I Newly Diagnosed GBM With Temozolomide, Radiation, and Minocycline Followed by Adjuvant Minocycline/Temozolomide (D-TERMINED) malignant glioma Minocycline (NPC317727) NP level
NCT03142451 A Study (Study 1) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea rosacea Minocycline (NPC317727) NP level
NCT02110810 Indomethacin Decreases Post-ERCP Pancreatitis acute pancreatitis Glycerin (NPC157340) NP level
NCT01320982 Minocycline, Acetylsalicylic Acid or Pramipexole vs Placebo in Patients With Schizophrenia or Schizoaffective Disorder schizoaffective disorder;schizophrenia Minocycline (NPC317727) NP level
NCT00579644 Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone rheumatoid arthritis Minocycline (NPC317727) NP level
NCT01083420 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus oral lichen planus Minocycline (NPC317727) NP level
NCT01422148 Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery atrial fibrillation Minocycline (NPC317727) NP level
NCT00841256 Multicenter Trial of Sublingual Immunotherapy With a Solution of Grass Pollen Allergen Extract in Children allergic conjunctivitis Glycerin (NPC157340) NP level
NCT02703363 Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression bipolar disorder;depressive disorder Minocycline (NPC317727) NP level
NCT01636934 Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy lung cancer Minocycline (NPC317727) NP level
NCT03369951 Minocycline Pharmacokinetics (ACUMIN) bacterial disease Minocycline (NPC317727) NP level
NCT03040128 Use of Minocycline in Intracerebral Hemorrhage intracerebral hemorrhage Minocycline (NPC317727) NP level
NCT04608500 A Study (Study 2) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea rosacea Minocycline (NPC317727) NP level
NCT00047723 Minocycline to Treat Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis Minocycline (NPC317727) NP level
NCT01171326 Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Impetigo Patients impetigo Minocycline (NPC317727) NP level
NCT00456677 Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma asthma Minocycline (NPC317727) NP level
NCT01755611 Bioequivalence Minocycline Bioequivalence infection Minocycline (NPC317727) NP level
NCT03064282 Prostatic Hyperplasia Treatment and Cancer Prevention benign prostatic hyperplasia Papaverine (NPC195268) NP level
NCT01828203 Minocycline in Acute Spinal Cord Injury (MASC) Spinal cord injury Minocycline (NPC317727) NP level
NCT01693523 Minocycline Study in Pancreatic Cancer Patients pancreatic carcinoma Minocycline (NPC317727) NP level
NCT03901144 A NOVel Moisturiser for Atopic Dermatitis: Effect on the Skin Barrier atopic eczema Glycerin (NPC157340) NP level
NCT01695291 Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD obsessive-compulsive disorder Minocycline (NPC317727) NP level
NCT00401921 A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy internal carotid artery stenosis Minocycline (NPC317727) NP level
NCT03117530 Measuring Brain Inflammation in Autism autism spectrum disorder Minocycline (NPC317727) NP level
NCT00536042 Open-Label Trial of the Use of Minocycline in the Treatment of Asthma asthma Minocycline (NPC317727) NP level
NCT00580606 A Randomized, Double-Blind Placebo-Controlled Peanut Sublingual Immunotherapy Trial peanut allergic reaction Glycerin (NPC157340) NP level
NCT02770378 A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma glioblastoma multiforme Minocycline (NPC317727) NP level
NCT03414502 Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response rheumatoid arthritis Minocycline (NPC317727) NP level
NCT05474950 Minocycline Treatment for Cystoid Macular Edema cystoid macular edema Minocycline (NPC317727) NP level
NCT02193269 The Effects of Minocycline in Humans memory impairment Minocycline (NPC317727) NP level
NCT02815332 BPX-01 Minocycline Topical Gel in the Treatment of Acne Vulgaris acne Minocycline (NPC317727) NP level
NCT04594733 The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia fibromyalgia Minocycline (NPC317727) NP level
NCT02051296 Minocycline to Reduce Pain After Carpal Tunnel Release Chronic pain Minocycline (NPC317727) NP level
NCT02946788 Open Label Photo-Documentation Study Of BPX-01 Minocycline Gel acne Minocycline (NPC317727) NP level
NCT02947763 Single Versus Multiple Visits Endodontic Treatment Periapical Periodontitis Minocycline (NPC317727) NP level
NCT01474499 A Trial of Docusate Sodium and Sorbitol Rectal Solution for the in Patients With Constipation Constipation Glycerin (NPC157340) NP level
NCT02541500 An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence heroin dependence Minocycline (NPC317727) NP level
NCT00240513 Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin acne Minocycline (NPC317727) NP level
NCT04291456 Minocycline in MS: Confirmation of Benefit multiple sclerosis Minocycline (NPC317727) NP level
NCT01793051 Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma multiple myeloma Minocycline (NPC317727) NP level
NCT01297816 Evaluation of Neuroprotective Effect of Minocycline retinal detachment Minocycline (NPC317727) NP level
NCT00154895 Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax Pneumothorax Minocycline (NPC317727) NP level
NCT00988026 Safety and Efficacy Comparison of Minocycline Microgranules Versus Lymecycline in the Treatment of Mild to Moderate Acne acne Minocycline (NPC317727) NP level
NCT02044341 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media Otitis media Glycerin (NPC157340) NP level
NCT02250859 A Pharmacokinetic Study of Minocycline in Male and Female Volunteers acne Minocycline (NPC317727) NP level
NCT02140164 Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa retinitis pigmentosa Minocycline (NPC317727) NP level
NCT01206348 Combination Treatment for Moderate to Severe Acne acne Minocycline (NPC317727) NP level
NCT01173692 Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study. oropharynx cancer Minocycline (NPC317727) NP level
NCT00559494 Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury Spinal cord injury Minocycline (NPC317727) NP level
NCT01468844 Minocycline to Treat Central Retinal Vein Occlusion retinal vein occlusion Minocycline (NPC317727) NP level
NCT02060149 The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline pneumonia Minocycline (NPC317727) NP level
NCT02569307 Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States psychosis Minocycline (NPC317727) NP level
NCT05032781 Intra-Arterial Neuroprotective Agents and Cold Saline in Ischemic Stroke Intervention stroke Minocycline (NPC317727) NP level
NCT00145106 Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris acne Minocycline (NPC317727) NP level
NCT00029874 Minocycline in Patients With Huntington's Disease Huntington disease Minocycline (NPC317727) NP level
NCT01048983 Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC) non-small cell lung carcinoma Minocycline (NPC317727) NP level
NCT01574742 Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression unipolar depression Minocycline (NPC317727) NP level
NCT02178813 The Safety of High Dose Minocycline in the Patient Population Undergoing Carotid Revascularization stroke Minocycline (NPC317727) NP level
NCT00666887 Minocycline in Clinically Isolated Syndromes (CIS) multiple sclerosis Minocycline (NPC317727) NP level
NCT00733057 Minocycline for the Treatment of Early-Phase Schizophrenia neurobehavioral manifestations Minocycline (NPC317727) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Schizophrenia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A20
 PDE10A
 NCT02907437,NCT02533232,NCT01320982,NCT02928965
Rosacea
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED90
 NCT03050086,NCT01134991,NCT04608500,NCT03142451,NCT03263273
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 PDE10A,MAPT,BLM,PDE3A,LMNA
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62.Z
 NCT00361257,NCT01575405,NCT01687218,NCT01575418
Ischaemic/haemorrhagic stroke
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B20
 NCT03320018,NCT05032781,NCT00630396,NCT02178813
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 BLM,PDE10A,MAPT,PDE3B
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 BLM,PDE10A,CYP2C19,LMNA
Asthma
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA23
 PDE3A
 NCT00456677,NCT00536042
Non-small cell lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 NCT05136846,NCT03824327,NCT01048983
Bipolar disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A60
 NCT01403662,NCT01429272,NCT02703363
Multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40
 NCT04291456,NCT00666887,NCT00203112
Depressive disorders, unspecified
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A7Z
 NCT02703363,NCT01403662,NCT01809340
Pulmonary hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BB01
 NCT04478500,NCT02133885,NCT02213575
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 BLM,PDE10A,LMNA
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 BLM,MAPT,MAPT
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 CREBBP,MAPT
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 CREBBP,PDE10A
Choreiform disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A01
 PDE10A,MAPT
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 CREBBP
 NCT00080808
Parkinsonism
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00
 MAPT
 NCT00063193
Depression
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A70-6A7Z
 NCT03947827,NCT01574742
Intracerebral haemorrhage
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B00
 NCT01805895,NCT03040128
Fragile X chromosome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD55
 NCT02998151,NCT02680379
Obsessive-compulsive disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6B20
 NCT01695291,NCT00515255
Amyotrophic lateral sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B60.0
 NCT00355576,NCT00047723
Injury of spinal cord, level unspecified
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: ND51.2
 NCT01828203,NCT00559494
Multiple myeloma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A83
 NCT01793051,NCT01283997
Schizoaffective disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A21
 NCT01320982,NCT02533232
Neuropathy, ataxia, and retinitis pigmentosa
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C73.1
 NCT04068207,NCT02140164
Schizophrenia or other primary psychotic disorders, unspecified
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A2Z
 NCT02569307,NCT00916461
Periodontal disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA0C
 NCT00371332,NCT00662532
Rheumatoid arthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA20
 NCT03414502,NCT00579644
Huntington disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A01.10
 NCT00277355,NCT00029874
Autism spectrum disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A02
 NCT04031755,NCT03117530
Retinal vascular occlusion
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B74
 NCT01468831,NCT01468844
Constipation
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME05.0
 NCT01335386,NCT01474499
Head and neck cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D42
 NCT01219673,NCT02055963
Single episode depressive disorder, severe, without psychotic symptoms
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A70.3
 NCT02456948,NCT02362529
NA
Disease Category: NA
Disease ICD-11 Code: NA
 NCT01539564,NCT01517334
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 BLM,PDE3B
Melanoma of skin
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 PDE10A,PDE3A
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 BLM,LMNA
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 BLM,PDE3A
Acne vulgaris
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED80
 NCT00240513,NCT01362010,NCT02250859,NCT02815332,NCT00988026,NCT02946788,NCT00145106,NCT01206348,NCT02815280,NCT02815267,NCT00392223,NCT02695446
Heart failure
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD10-BD1Z
 PDE3A
Chronic arterial occlusive disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD4Z
 PDE3A
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 MAPT
Systemic sclerosis
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A42
 CREBBP
Mild neurocognitive disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D71
 MAPT
Inborn purine/pyrimidine/nucleotide metabolism error
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C55
 PDE10A
Irritable bowel syndrome
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD91
 PDE10A
Thrombocytosis
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B63
 PDE3A
Diseases of the visual system, unspecified
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9E1Z
 NCT00243711
Haemorrhage, not elsewhere classified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG27
 NCT02113176
Esophageal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 NCT01746043
Neurobehavioral disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00-8A0Z
 NCT00733057
Acute pancreatitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DC31
 NCT02110810
Intracranial injury, unspecified
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NA07.Z
 NCT01058395
Other specified disorders of the retina
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B7Y
 NCT05474950
Atrial fibrillation
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC81.3
 NCT01422148
Allergic/hypersensitivity disorder
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A80-4A8Z
 NCT02936830
Bacterial meningitis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D01.0
 NCT00619203
Macular degeneration
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B75
 NCT02564978
Angelman syndrome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD90.0
 NCT02056665
Asymptomatic stenosis of intracranial or extracranial artery
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD55
 NCT00401921
Allergic conjunctivitis
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9A60.02
 NCT00841256
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 NCT03369951
Chronic pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30
 NCT02051296
Otitis media
Disease Category: 10.Diseases of the ear or mastoid process
Disease ICD-11 Code: AA80-AB0Z
 NCT02044341
Prostate hyperplasia
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA90
 NCT03064282
Gastroenteritis or colitis without specification of origin
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A40.0
 NCT02711241
Retinal detachment
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B73
 NCT01297816
Colorectal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B91
 NCT01906008
Pneumothorax
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB21
 NCT00154895
Glioma, malignant
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH4RQ3
 NCT02272270
Idiopathic pulmonary fibrosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB03.4
 NCT00203697
Opioid dependence, unspecified
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C43.2Z
 NCT02541500
Atopic eczema
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA80
 NCT03901144
Central nervous system disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A04-8D87
 NCT01580969
Relapsing-remitting multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40.0
 NCT01134627
Malignant neoplasms of oropharynx
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6A
 NCT01173692
Chronic widespread pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30.01
 NCT04594733
Alcohol dependence
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40.2
 NCT02187211
Lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 NCT01636934
Lichen planus
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA91
 NCT01083420
COVID-19
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D6Y
 NCT05398705
Malignant neoplasm of pancreas, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.Z
 NCT01693523
Cystic fibrosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA25
 NCT03489629
Osteomyelitis or osteitis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB84
 NCT02099240
Skin disease
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA00-EM0Z
 NCT01938508
Glioblastoma, primary, NOS
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH0MB1
 NCT02770378
Age-associated cognitive decline
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB21.0
 NCT02193269
Herpes simplex infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F00
 NCT01755611
Pneumonia
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA40
 NCT02060149
Periapical periodontitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA09.7
 NCT02947763
Pleomorphic sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B54
 NCT00003667
Impetigo
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1B72
 NCT01171326
Primary sclerosing cholangitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB96.2
 NCT00630942
Chronic neuropathic pain, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30.5Z
 NCT01314482
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 PDE3B
Dengue fever, unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D2Z
 PDE3A
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 BLM
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 BLM
Squamous cell carcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.2
 BLM
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 LMNA
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 LMNA
Malignant neoplasms of oesophagus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 BLM
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 BLM
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 CYP2C19
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 BLM
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 BLM
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 LMNA
Dilated cardiomyopathy
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC43.0
 PDE3A
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 MAPT
Invasive carcinoma of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C61
 BLM
Ebola virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D60.01
 PDE3A
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 BLM
Gliomas of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.0
 BLM

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
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chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
dyhou22@m.fudan.edu.cn
Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
yhfeng22@m.fudan.edu.cn

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