Collective Molecular Activities of the Plant: Castilleja Sulphurea
Plant ID: NPO313
Plant Latin Name: Castilleja Sulphurea
Taxonomy Genus: Castilleja
Taxonomy Family: Orobanchaceae
Plant External Links:
NCBI TaxonomyDB:
188296
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
32 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
30 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
15 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99707
Ingredient ID: NPC95468
Ingredient ID: NPC94245
Ingredient ID: NPC93850
Ingredient ID: NPC90185
Ingredient ID: NPC74914
Ingredient ID: NPC64332
Ingredient ID: NPC57268
Ingredient ID: NPC51681
Ingredient ID: NPC32411
Ingredient ID: NPC295998
Ingredient ID: NPC280399
Ingredient ID: NPC26960
Ingredient ID: NPC267077
Ingredient ID: NPC26544
Ingredient ID: NPC257790
Ingredient ID: NPC253714
Ingredient ID: NPC24238
Ingredient ID: NPC233529
Ingredient ID: NPC233224
Ingredient ID: NPC226762
Ingredient ID: NPC204120
Ingredient ID: NPC203468
Ingredient ID: NPC195986
Ingredient ID: NPC174191
Ingredient ID: NPC164023
Ingredient ID: NPC162994
Ingredient ID: NPC157944
Ingredient ID: NPC15743
Ingredient ID: NPC139209
Ingredient ID: NPC126935
Ingredient ID: NPC116711
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 7 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02612259 | A Phase II, Randomized, Double-blind, Placebo-controlled, in Parallel Groups Clinical Trial to Assess the Safety and Efficacy of Dietary Supplementation With Tryptophan to Achieve Weight Loss, and Its Neuropsychological Effects in Adolescents With Obesity | obesity | Tryptophan (NPC203468) | NP level |
| NCT00567931 | 1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery | neoplasm | Tryptophan (NPC203468) | NP level |
| NCT02067975 | Tryptophan MRI in People With Schizophrenia and Healthy Controls | schizophrenia | Tryptophan (NPC203468) | NP level |
| NCT02618824 | Role of Terminal Warm Blood Cardioplegia as Myocardial Protection in the Use of Histidine-Tryptophan-Ketoglutarate Cardioplegia in Complex Congenital Heart Surgery | congenital heart disease | Tryptophan (NPC203468) | NP level |
| NCT01191216 | 1-Methyl-D-Tryptophan and Docetaxel in Treating Patients With Metastatic Solid Tumors | neoplasm | Tryptophan (NPC203468) | NP level |
| NCT01042535 | Vaccine Therapy and 1-MT in Treating Patients With Metastatic Breast Cancer | male breast carcinoma | Tryptophan (NPC203468) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00567931,NCT01191216
|
Structural developmental anomaly of heart or great vessels, unspecifiedDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA8Z |
NCT02618824
|
Carcinoma of male breastDisease Category: X.Extension CodesDisease ICD-11 Code: XH5KW8 |
NCT01042535
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT02067975
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00000324
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02612259
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
