CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Ferula Assafoetida

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO3083
Plant Latin Name: Ferula Assafoetida
Taxonomy Genus: Ferula
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

74 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

69 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

27 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC9880

Ingredient ID: NPC92133

Ingredient ID: NPC88603

Ingredient ID: NPC88566

Ingredient ID: NPC83470

Ingredient ID: NPC78551

Ingredient ID: NPC71853

Ingredient ID: NPC71703

Ingredient ID: NPC64176

Ingredient ID: NPC61828

Ingredient ID: NPC60556

Ingredient ID: NPC3780

Ingredient ID: NPC309182

Ingredient ID: NPC306365

Ingredient ID: NPC306256

Ingredient ID: NPC301964

Ingredient ID: NPC296337

Ingredient ID: NPC295474

Ingredient ID: NPC293804

Ingredient ID: NPC292473

Ingredient ID: NPC288932

Ingredient ID: NPC278821

Ingredient ID: NPC277907

Ingredient ID: NPC271118

Ingredient ID: NPC268862

Ingredient ID: NPC254529

Ingredient ID: NPC25293

Ingredient ID: NPC252152

Ingredient ID: NPC248726

Ingredient ID: NPC239039

Ingredient ID: NPC234231

Ingredient ID: NPC231738

Ingredient ID: NPC230475

Ingredient ID: NPC227670

Ingredient ID: NPC226259

Ingredient ID: NPC219596

Ingredient ID: NPC213749

Ingredient ID: NPC211891

Ingredient ID: NPC209275

Ingredient ID: NPC208361

Ingredient ID: NPC207844

Ingredient ID: NPC198658

Ingredient ID: NPC19488

Ingredient ID: NPC192962

Ingredient ID: NPC191498

Ingredient ID: NPC190810

Ingredient ID: NPC184207

Ingredient ID: NPC175987

Ingredient ID: NPC174006

Ingredient ID: NPC172260

Ingredient ID: NPC166362

Ingredient ID: NPC165075

Ingredient ID: NPC155182

Ingredient ID: NPC15074

Ingredient ID: NPC146388

Ingredient ID: NPC143436

Ingredient ID: NPC141777

Ingredient ID: NPC13991

Ingredient ID: NPC139353

Ingredient ID: NPC138149

Ingredient ID: NPC138113

Ingredient ID: NPC137201

Ingredient ID: NPC135648

Ingredient ID: NPC135388

Ingredient ID: NPC131198

Ingredient ID: NPC128808

Ingredient ID: NPC126173

Ingredient ID: NPC125347

Ingredient ID: NPC124161

Ingredient ID: NPC114239

Ingredient ID: NPC114011

Ingredient ID: NPC109813

Ingredient ID: NPC108494

Ingredient ID: NPC104569

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Therapeutic Target	Transcription factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	1

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT05432284	Behavioral Pharmacology of THC and Beta-Myrcene	cannabis dependence	Myrcene (NPC138113)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	TP53,CNR2
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	TP53
Stomach cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	TP53
Head and neck cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D42	TP53
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	TP53
Metastatic liver/bile duct neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D80	TP53
Lip/oral cavity/pharynx neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6E	TP53
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CNR2
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	CNR2
Esophageal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	TP53
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	CNR2
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CNR2
Endometrial cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76	TP53
Fallopian tube cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C74	TP53
Inborn lipid metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52	CNR2
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	TP53
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CNR2
Cervical cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C77	TP53
Malignant haematopoietic neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B33	TP53
Peritoneal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C51	TP53
Kidney failure Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB60-GB6Z	TP53
Liposarcoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B59	TP53
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	TP53
Transplant rejection Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE84	TP53
Ovarian dysfunction Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A80	TP53
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	CNR2
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	TP53
Myelodysplastic syndrome Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A37	TP53
Bladder cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	TP53
Mature B-cell leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A82	TP53
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	TP53
Ovarian cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73	TP53
Cannabis use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C41	NCT05432284
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	TP53
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	TP53
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	TP53
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	CNR2
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CNR2
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	CNR2
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CNR2
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	CNR2
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CNR2
Human immunodeficiency virus disease without mention of tuberculosis or malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C62	CNR2
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CNR2

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Ferula Assafoetida

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

74 All known Ingredients in Total

69 Ingredients with Acceptable Bioavailablity

27 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Diffuse large B-cell lymphomas

Solid tumour/cancer

Stomach cancer

Head and neck cancer

Pancreatic cancer

Metastatic liver/bile duct neoplasm

Lip/oral cavity/pharynx neoplasm

Atopic eczema

Crohn disease

Esophageal cancer

Pain, unspecified

Insomnia

Endometrial cancer

Fallopian tube cancer

Inborn lipid metabolism error

Acute myeloid leukaemia

Attention deficit hyperactivity disorder

Cervical cancer

Malignant haematopoietic neoplasm

Peritoneal cancer

Kidney failure

Liposarcoma

Chronic arterial occlusive disease

Transplant rejection

Ovarian dysfunction

General pain disorder

Colorectal cancer

Myelodysplastic syndrome

Bladder cancer

Mature B-cell leukaemia

Brain cancer

Ovarian cancer

Cannabis use disorder

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Malignant neoplasms of biliary tract, distal bile duct

Leishmaniasis

Adenocarcinoma of pancreas

Mesothelioma of pleura

Cytomegaloviral disease

Malignant neoplasms of thymus

Invasive carcinoma of breast

Human immunodeficiency virus disease without mention of tuberculosis or malaria

Germ cell tumour of testis

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities