CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Calotropis Gigantea

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PLANiTS DNA barcode

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Taxonomic Information

Plant ID: NPO30295
Plant Latin Name: Calotropis Gigantea
Taxonomy Genus: Calotropis
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 95173-1

Used in Medicines

Unknown.

Geographical Distribution

Bangladesh; Nepal; Cambodia; Laos; Venezuela; Australia; Cuba; China; Thailand; Tanzania; Maldives; Philippines; Indonesia; United States; Trinidad and Tobago; Vietnam; Angola; Myanmar; India; Mozambique; Colombia; Sri Lanka; Kenya; Fiji

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

38 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

11 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)