Collective Molecular Activities of the Plant: Triglochin Maritima
Plant ID: NPO29466
Plant Latin Name: Triglochin Maritima
Taxonomy Genus: Triglochin
Taxonomy Family: Juncaginaceae
Plant External Links:
NCBI TaxonomyDB:
55501
Plant-of-the-World-Online:
n.a.
Country/Region:
IndiaTraditional Medicine System:
Indian FolkIndia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
150 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
43 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
59 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99408
Ingredient ID: NPC97680
Ingredient ID: NPC97131
Ingredient ID: NPC9666
Ingredient ID: NPC92569
Ingredient ID: NPC88130
Ingredient ID: NPC87263
Ingredient ID: NPC86412
Ingredient ID: NPC86133
Ingredient ID: NPC84319
Ingredient ID: NPC82853
Ingredient ID: NPC81995
Ingredient ID: NPC8094
Ingredient ID: NPC79834
Ingredient ID: NPC79742
Ingredient ID: NPC75234
Ingredient ID: NPC74942
Ingredient ID: NPC74428
Ingredient ID: NPC72924
Ingredient ID: NPC6773
Ingredient ID: NPC57495
Ingredient ID: NPC5447
Ingredient ID: NPC52622
Ingredient ID: NPC51700
Ingredient ID: NPC46274
Ingredient ID: NPC44996
Ingredient ID: NPC446
Ingredient ID: NPC44260
Ingredient ID: NPC44083
Ingredient ID: NPC43918
Ingredient ID: NPC43357
Ingredient ID: NPC41424
Ingredient ID: NPC40702
Ingredient ID: NPC38408
Ingredient ID: NPC38145
Ingredient ID: NPC380
Ingredient ID: NPC37502
Ingredient ID: NPC33611
Ingredient ID: NPC32089
Ingredient ID: NPC311907
Ingredient ID: NPC31039
Ingredient ID: NPC307063
Ingredient ID: NPC305959
Ingredient ID: NPC302436
Ingredient ID: NPC300790
Ingredient ID: NPC295417
Ingredient ID: NPC293908
Ingredient ID: NPC293378
Ingredient ID: NPC291957
Ingredient ID: NPC289196
Ingredient ID: NPC287965
Ingredient ID: NPC285839
Ingredient ID: NPC285047
Ingredient ID: NPC283655
Ingredient ID: NPC281570
Ingredient ID: NPC279121
Ingredient ID: NPC27657
Ingredient ID: NPC276349
Ingredient ID: NPC272123
Ingredient ID: NPC26861
Ingredient ID: NPC267627
Ingredient ID: NPC26703
Ingredient ID: NPC265318
Ingredient ID: NPC265273
Ingredient ID: NPC264317
Ingredient ID: NPC264145
Ingredient ID: NPC261831
Ingredient ID: NPC259838
Ingredient ID: NPC259533
Ingredient ID: NPC258733
Ingredient ID: NPC25162
Ingredient ID: NPC249823
Ingredient ID: NPC248956
Ingredient ID: NPC24858
Ingredient ID: NPC247713
Ingredient ID: NPC243728
Ingredient ID: NPC237898
Ingredient ID: NPC237643
Ingredient ID: NPC237202
Ingredient ID: NPC230301
Ingredient ID: NPC230085
Ingredient ID: NPC228914
Ingredient ID: NPC227030
Ingredient ID: NPC225710
Ingredient ID: NPC225585
Ingredient ID: NPC221758
Ingredient ID: NPC220831
Ingredient ID: NPC219600
Ingredient ID: NPC219092
Ingredient ID: NPC218860
Ingredient ID: NPC217586
Ingredient ID: NPC213352
Ingredient ID: NPC212176
Ingredient ID: NPC211550
Ingredient ID: NPC20791
Ingredient ID: NPC205037
Ingredient ID: NPC202713
Ingredient ID: NPC19783
Ingredient ID: NPC196336
Ingredient ID: NPC195874
Ingredient ID: NPC195491
Ingredient ID: NPC195196
Ingredient ID: NPC192638
Ingredient ID: NPC191306
Ingredient ID: NPC191106
Ingredient ID: NPC190501
Ingredient ID: NPC189224
Ingredient ID: NPC187838
Ingredient ID: NPC184571
Ingredient ID: NPC184171
Ingredient ID: NPC181823
Ingredient ID: NPC179548
Ingredient ID: NPC178383
Ingredient ID: NPC178134
Ingredient ID: NPC175854
Ingredient ID: NPC175793
Ingredient ID: NPC175013
Ingredient ID: NPC173977
Ingredient ID: NPC169749
Ingredient ID: NPC169022
Ingredient ID: NPC168636
Ingredient ID: NPC168623
Ingredient ID: NPC166851
Ingredient ID: NPC165382
Ingredient ID: NPC163076
Ingredient ID: NPC16024
Ingredient ID: NPC157340
Ingredient ID: NPC155825
Ingredient ID: NPC153031
Ingredient ID: NPC146289
Ingredient ID: NPC146066
Ingredient ID: NPC144109
Ingredient ID: NPC143851
Ingredient ID: NPC142415
Ingredient ID: NPC14030
Ingredient ID: NPC139622
Ingredient ID: NPC135222
Ingredient ID: NPC129530
Ingredient ID: NPC125352
Ingredient ID: NPC125136
Ingredient ID: NPC124639
Ingredient ID: NPC123259
Ingredient ID: NPC121162
Ingredient ID: NPC120503
Ingredient ID: NPC119289
Ingredient ID: NPC113733
Ingredient ID: NPC109878
Ingredient ID: NPC104316
Ingredient ID: NPC104281
Ingredient ID: NPC104222
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Therapeutic Target | Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 102 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00003667 | Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma | sarcoma | Glycerin (NPC157340) | NP level |
| NCT00113854 | Mannitol as Adjunct Therapy for Childhood Cerebral Malaria | malaria | Mannitol (NPC86412) | NP level |
| NCT00117208 | Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00189007 | Antenatal Allopurinol During Fetal Hypoxia | fetal hypoxia | Mannitol (NPC86412) | NP level |
| NCT00243711 | A Multi-Center Randomized Study to Evaluate the Efficacy and Safety of an Investigational Lubricant Eye Drop | dry eye syndrome | Glycerin (NPC157340) | NP level |
| NCT00249951 | Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants | Nephrocalcinosis | Citric Acid (NPC293378) | NP level |
| NCT00251056 | Mannitol Dose Response Study in Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00277537 | Safety and Efficacy of Bronchitol in Bronchiectasis | Bronchiectasis | Mannitol (NPC86412) | NP level |
| NCT00303849 | Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors | anaplastic oligodendroglioma | Mannitol (NPC86412) | NP level |
| NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1,INSR,KDR,AURKB,PPARA,DPP4,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
GSK3B,AXL,TOP2A,RELA,FLT3,SRC,PTPRC,AURKB,TP53,PIM1
|
Acute pancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31 |
NCT02110810
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM,CDK1,TOP2A,CA5A,CA7,F2,GPR35,XDH,MMP12,ACHE,AKR1B10,NPSR1,AURKB,CA12
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM,NUAK1,RECQL,LMNA,ABCG2,FUT7,DPP4,ANTXR2,PTPN1,ALOX5,CYP1B1,SNCA,ALOX15,CA7,F2,TEK,AXL,XDH,CDC25B,PIM1,PTPRC,POLB,MET,F10,ACHE,AKR1B10,NPSR1,AURKB,CES1,HIF1A
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,NOX4,ALOX15
NCT01912820 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
