Collective Molecular Activities of the Plant: Juglans Nigra
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Alterative; Anodyne; Antiinflammatory; Astringent; Blood purifier; Detergent; Laxative; Pectoral; Vermifuge
Romania; Italy; Denmark; United States; Austria; Germany; Belgium; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
247 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
150 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
126 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99310
Ingredient ID: NPC99108
Ingredient ID: NPC97444
Ingredient ID: NPC97418
Ingredient ID: NPC96830
Ingredient ID: NPC95487
Ingredient ID: NPC94610
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC92754
Ingredient ID: NPC89747
Ingredient ID: NPC89442
Ingredient ID: NPC87061
Ingredient ID: NPC85990
Ingredient ID: NPC85813
Ingredient ID: NPC85379
Ingredient ID: NPC85346
Ingredient ID: NPC82648
Ingredient ID: NPC82623
Ingredient ID: NPC8235
Ingredient ID: NPC81559
Ingredient ID: NPC80985
Ingredient ID: NPC7943
Ingredient ID: NPC78662
Ingredient ID: NPC78500
Ingredient ID: NPC77674
Ingredient ID: NPC77249
Ingredient ID: NPC76256
Ingredient ID: NPC75975
Ingredient ID: NPC75236
Ingredient ID: NPC7523
Ingredient ID: NPC74296
Ingredient ID: NPC73592
Ingredient ID: NPC73021
Ingredient ID: NPC71002
Ingredient ID: NPC6941
Ingredient ID: NPC68324
Ingredient ID: NPC68040
Ingredient ID: NPC66352
Ingredient ID: NPC65873
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Ingredient ID: NPC63094
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Ingredient ID: NPC62045
Ingredient ID: NPC6107
Ingredient ID: NPC59884
Ingredient ID: NPC59581
Ingredient ID: NPC57639
Ingredient ID: NPC55681
Ingredient ID: NPC52754
Ingredient ID: NPC52403
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Ingredient ID: NPC490222
Ingredient ID: NPC490204
Ingredient ID: NPC489907
Ingredient ID: NPC489877
Ingredient ID: NPC43217
Ingredient ID: NPC3964
Ingredient ID: NPC34930
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Ingredient ID: NPC330888
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Ingredient ID: NPC311317
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Ingredient ID: NPC306414
Ingredient ID: NPC305835
Ingredient ID: NPC305826
Ingredient ID: NPC304929
Ingredient ID: NPC302760
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Ingredient ID: NPC299948
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Ingredient ID: NPC278070
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Ingredient ID: NPC275462
Ingredient ID: NPC273385
Ingredient ID: NPC272614
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC267887
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Ingredient ID: NPC26193
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Ingredient ID: NPC209970
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Ingredient ID: NPC201579
Ingredient ID: NPC199620
Ingredient ID: NPC199072
Ingredient ID: NPC197645
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Ingredient ID: NPC196924
Ingredient ID: NPC195419
Ingredient ID: NPC195366
Ingredient ID: NPC195064
Ingredient ID: NPC194856
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Ingredient ID: NPC192638
Ingredient ID: NPC190901
Ingredient ID: NPC188910
Ingredient ID: NPC188668
Ingredient ID: NPC187770
Ingredient ID: NPC186107
Ingredient ID: NPC185755
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Ingredient ID: NPC18457
Ingredient ID: NPC184457
Ingredient ID: NPC18285
Ingredient ID: NPC180311
Ingredient ID: NPC178158
Ingredient ID: NPC178134
Ingredient ID: NPC17810
Ingredient ID: NPC176740
Ingredient ID: NPC175794
Ingredient ID: NPC17461
Ingredient ID: NPC173637
Ingredient ID: NPC169479
Ingredient ID: NPC169392
Ingredient ID: NPC167400
Ingredient ID: NPC166825
Ingredient ID: NPC165266
Ingredient ID: NPC165005
Ingredient ID: NPC164981
Ingredient ID: NPC164646
Ingredient ID: NPC163076
Ingredient ID: NPC16287
Ingredient ID: NPC159518
Ingredient ID: NPC156654
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Ingredient ID: NPC156255
Ingredient ID: NPC154477
Ingredient ID: NPC154186
Ingredient ID: NPC152971
Ingredient ID: NPC152451
Ingredient ID: NPC152162
Ingredient ID: NPC150950
Ingredient ID: NPC150402
Ingredient ID: NPC149184
Ingredient ID: NPC148192
Ingredient ID: NPC147983
Ingredient ID: NPC146550
Ingredient ID: NPC144909
Ingredient ID: NPC144054
Ingredient ID: NPC143332
Ingredient ID: NPC141481
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Ingredient ID: NPC139472
Ingredient ID: NPC139416
Ingredient ID: NPC139206
Ingredient ID: NPC136514
Ingredient ID: NPC1321
Ingredient ID: NPC130590
Ingredient ID: NPC126681
Ingredient ID: NPC126029
Ingredient ID: NPC124624
Ingredient ID: NPC12309
Ingredient ID: NPC12241
Ingredient ID: NPC120649
Ingredient ID: NPC117176
Ingredient ID: NPC116775
Ingredient ID: NPC116520
Ingredient ID: NPC115672
Ingredient ID: NPC114743
Ingredient ID: NPC11433
Ingredient ID: NPC113665
Ingredient ID: NPC110923
Ingredient ID: NPC108628
Ingredient ID: NPC108288
Ingredient ID: NPC108218
Ingredient ID: NPC107704
Ingredient ID: NPC104679
Ingredient ID: NPC104222
Ingredient ID: NPC102617
Ingredient ID: NPC102058
Ingredient ID: NPC101822
Ingredient ID: NPC101475
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 522 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Folic Acid (NPC147983);Pyridoxine (NPC269919);Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Ascorbate (NPC187770);Folic Acid (NPC147983);Beta Carotene (NPC17810);Pyridoxine (NPC269919) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03522922
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
INSR,AKR1B1,KDR,AURKB,PPARA,DPP4,FFAR1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
GSK3B,AXL,NFKB1,PIM1,MAPT,SRC,AURKB,IDO1,FLT3,TP53,BCL2
NCT00329498,NCT00184054 |
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04404387
|
Acute viral hepatitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50 |
NCT00108589
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
