Collective Molecular Activities of the Plant: Euonymus Alatus
Plant ID: NPO29118
Plant Latin Name: Euonymus Alatus
Taxonomy Genus: Euonymus
Taxonomy Family: Celastraceae
Plant External Links:
NCBI TaxonomyDB:
4307
Plant-of-the-World-Online:
n.a.
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCMMedicinal Functions:
Anodyne; Anthelmintic; Antiphlogistic; Antipruritic; Astringent; Blood tonic; Cancer; Carminative; Emmenagogue; Hypoglycaemic
South Korea; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
98 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
66 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
62 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98680
Ingredient ID: NPC95615
Ingredient ID: NPC92507
Ingredient ID: NPC87725
Ingredient ID: NPC84810
Ingredient ID: NPC82920
Ingredient ID: NPC81186
Ingredient ID: NPC79943
Ingredient ID: NPC7903
Ingredient ID: NPC63118
Ingredient ID: NPC6300
Ingredient ID: NPC62765
Ingredient ID: NPC62290
Ingredient ID: NPC61477
Ingredient ID: NPC52686
Ingredient ID: NPC50898
Ingredient ID: NPC470098
Ingredient ID: NPC470097
Ingredient ID: NPC470096
Ingredient ID: NPC470095
Ingredient ID: NPC3862
Ingredient ID: NPC35208
Ingredient ID: NPC35069
Ingredient ID: NPC32441
Ingredient ID: NPC314267
Ingredient ID: NPC311485
Ingredient ID: NPC310604
Ingredient ID: NPC305186
Ingredient ID: NPC300166
Ingredient ID: NPC29883
Ingredient ID: NPC297815
Ingredient ID: NPC295992
Ingredient ID: NPC294902
Ingredient ID: NPC292056
Ingredient ID: NPC290791
Ingredient ID: NPC289660
Ingredient ID: NPC287657
Ingredient ID: NPC283217
Ingredient ID: NPC277924
Ingredient ID: NPC277493
Ingredient ID: NPC277400
Ingredient ID: NPC275463
Ingredient ID: NPC274613
Ingredient ID: NPC266441
Ingredient ID: NPC265800
Ingredient ID: NPC263367
Ingredient ID: NPC263261
Ingredient ID: NPC263124
Ingredient ID: NPC26065
Ingredient ID: NPC260397
Ingredient ID: NPC256853
Ingredient ID: NPC250486
Ingredient ID: NPC24490
Ingredient ID: NPC243728
Ingredient ID: NPC239128
Ingredient ID: NPC237727
Ingredient ID: NPC237031
Ingredient ID: NPC227017
Ingredient ID: NPC219876
Ingredient ID: NPC209360
Ingredient ID: NPC20791
Ingredient ID: NPC199914
Ingredient ID: NPC192638
Ingredient ID: NPC192065
Ingredient ID: NPC187107
Ingredient ID: NPC184447
Ingredient ID: NPC184248
Ingredient ID: NPC183181
Ingredient ID: NPC182570
Ingredient ID: NPC180261
Ingredient ID: NPC1788
Ingredient ID: NPC17879
Ingredient ID: NPC1786
Ingredient ID: NPC176740
Ingredient ID: NPC165172
Ingredient ID: NPC164697
Ingredient ID: NPC162806
Ingredient ID: NPC156654
Ingredient ID: NPC15658
Ingredient ID: NPC156502
Ingredient ID: NPC156353
Ingredient ID: NPC153783
Ingredient ID: NPC147821
Ingredient ID: NPC145134
Ingredient ID: NPC141765
Ingredient ID: NPC137419
Ingredient ID: NPC133990
Ingredient ID: NPC12640
Ingredient ID: NPC122212
Ingredient ID: NPC116775
Ingredient ID: NPC111888
Ingredient ID: NPC111247
Ingredient ID: NPC111201
Ingredient ID: NPC110899
Ingredient ID: NPC108831
Ingredient ID: NPC1075
Ingredient ID: NPC10737
Ingredient ID: NPC1037
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 281 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000437 | Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00000444 | Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch) | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00000447 | Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00000454 | Smoking Cessation in Alcoholism Treatment | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00004551 | Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch) | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00018148 | Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00018161 | Treatment to Quit Smoking | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00018187 | Combinations of Pharmacologic Smoking Cessation Treatments | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00032084 | S0002 - A Program to Quit Smoking With or Without Bupropion in Treating Patients With Stage I or II Non-Small Cell Lung Cancer Who Have Undergone Surgery | lung cancer | Nicotine (NPC182570) | NP level |
| NCT00046813 | Nicotine Patch for Nicotine Dependence in Individuals With Schizophrenia or Schizoaffective Disorder - 1 | nicotine dependence | Nicotine (NPC182570) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,DPP4,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
FLT3,TP53,NFKB1,AXL,PIM1,SRC,AURKB
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
CHRNA7,CHRFAM7A
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,MMP9,ACHE,CA12,CA7,AURKB,CDK1,XDH,MMP1,THPO,CYP2C9,TTR,TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPSR1,CHRNA3,DRD1,ACHE,CES1,CA7,POLB,AURKB,PIM1,MMP2,LMNA,AXL,CA14,XDH,CISD1,MMP1,HSD17B2,CA2,ALOX5,ABCG2,CYP1B1,MET,CYP2C9,NAPRT,TTR,DPP4,ALOX15,RECQL
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
