Collective Molecular Activities of the Plant: Litsea Cubeba
Country/Region:
China; Indonesia; IndiaTraditional Medicine System:
Indian Folk; TCM; AyurvedaMedicinal Functions:
Antiphlogistic; Expectorant
Nepal; Bangladesh; Myanmar; Indonesia; India; Cambodia; Vietnam; China; Laos; Japan; Taiwan; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
201 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
184 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
99 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9880
Ingredient ID: NPC96630
Ingredient ID: NPC95675
Ingredient ID: NPC89069
Ingredient ID: NPC88566
Ingredient ID: NPC87828
Ingredient ID: NPC85665
Ingredient ID: NPC84824
Ingredient ID: NPC81218
Ingredient ID: NPC79858
Ingredient ID: NPC78551
Ingredient ID: NPC76145
Ingredient ID: NPC75158
Ingredient ID: NPC7491
Ingredient ID: NPC71703
Ingredient ID: NPC71506
Ingredient ID: NPC69712
Ingredient ID: NPC68889
Ingredient ID: NPC67986
Ingredient ID: NPC67508
Ingredient ID: NPC66577
Ingredient ID: NPC66272
Ingredient ID: NPC64357
Ingredient ID: NPC64176
Ingredient ID: NPC61828
Ingredient ID: NPC60556
Ingredient ID: NPC60288
Ingredient ID: NPC60186
Ingredient ID: NPC59815
Ingredient ID: NPC57877
Ingredient ID: NPC54264
Ingredient ID: NPC54145
Ingredient ID: NPC51189
Ingredient ID: NPC49074
Ingredient ID: NPC48764
Ingredient ID: NPC47946
Ingredient ID: NPC479450
Ingredient ID: NPC479449
Ingredient ID: NPC479448
Ingredient ID: NPC479447
Ingredient ID: NPC474770
Ingredient ID: NPC45727
Ingredient ID: NPC44751
Ingredient ID: NPC43822
Ingredient ID: NPC43114
Ingredient ID: NPC42483
Ingredient ID: NPC41348
Ingredient ID: NPC40249
Ingredient ID: NPC38497
Ingredient ID: NPC3649
Ingredient ID: NPC36408
Ingredient ID: NPC34764
Ingredient ID: NPC325915
Ingredient ID: NPC3155
Ingredient ID: NPC312904
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Ingredient ID: NPC310907
Ingredient ID: NPC310210
Ingredient ID: NPC309182
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Ingredient ID: NPC300649
Ingredient ID: NPC29988
Ingredient ID: NPC297844
Ingredient ID: NPC297643
Ingredient ID: NPC297527
Ingredient ID: NPC296337
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Ingredient ID: NPC294136
Ingredient ID: NPC290189
Ingredient ID: NPC289653
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Ingredient ID: NPC288991
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Ingredient ID: NPC287446
Ingredient ID: NPC287331
Ingredient ID: NPC286774
Ingredient ID: NPC285267
Ingredient ID: NPC284731
Ingredient ID: NPC283655
Ingredient ID: NPC276009
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Ingredient ID: NPC256651
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Ingredient ID: NPC237408
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Ingredient ID: NPC229262
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Ingredient ID: NPC222001
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Ingredient ID: NPC221467
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Ingredient ID: NPC210560
Ingredient ID: NPC210316
Ingredient ID: NPC209275
Ingredient ID: NPC205421
Ingredient ID: NPC204242
Ingredient ID: NPC200370
Ingredient ID: NPC199539
Ingredient ID: NPC198658
Ingredient ID: NPC198586
Ingredient ID: NPC197942
Ingredient ID: NPC196711
Ingredient ID: NPC196490
Ingredient ID: NPC195246
Ingredient ID: NPC192135
Ingredient ID: NPC190810
Ingredient ID: NPC190771
Ingredient ID: NPC189036
Ingredient ID: NPC188334
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Ingredient ID: NPC182907
Ingredient ID: NPC182840
Ingredient ID: NPC18205
Ingredient ID: NPC180871
Ingredient ID: NPC180684
Ingredient ID: NPC178777
Ingredient ID: NPC178223
Ingredient ID: NPC177112
Ingredient ID: NPC175987
Ingredient ID: NPC173996
Ingredient ID: NPC17380
Ingredient ID: NPC173228
Ingredient ID: NPC168683
Ingredient ID: NPC168351
Ingredient ID: NPC166894
Ingredient ID: NPC166362
Ingredient ID: NPC165651
Ingredient ID: NPC16157
Ingredient ID: NPC160996
Ingredient ID: NPC155182
Ingredient ID: NPC154847
Ingredient ID: NPC154466
Ingredient ID: NPC154450
Ingredient ID: NPC148303
Ingredient ID: NPC14682
Ingredient ID: NPC144023
Ingredient ID: NPC143956
Ingredient ID: NPC141777
Ingredient ID: NPC13991
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC13789
Ingredient ID: NPC136508
Ingredient ID: NPC135257
Ingredient ID: NPC134764
Ingredient ID: NPC131981
Ingredient ID: NPC131769
Ingredient ID: NPC131431
Ingredient ID: NPC126240
Ingredient ID: NPC12319
Ingredient ID: NPC120926
Ingredient ID: NPC12053
Ingredient ID: NPC11489
Ingredient ID: NPC114526
Ingredient ID: NPC114239
Ingredient ID: NPC114011
Ingredient ID: NPC111888
Ingredient ID: NPC109813
Ingredient ID: NPC106250
Ingredient ID: NPC102091
Ingredient ID: NPC101285
Ingredient ID: NPC100502
Ingredient ID: NPC100445
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR6 | Serotonin 6 (5-HT6) receptor | P50406 | CHEMBL3371 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR1A | Serotonin 1a (5-HT1a) receptor | P08908 | CHEMBL214 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR5A | Serotonin 5a (5-HT5a) receptor | P47898 | CHEMBL3426 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR7 | Serotonin 7 (5-HT7) receptor | P34969 | CHEMBL3155 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2B | Serotonin 2b (5-HT2b) receptor | P41595 | CHEMBL1833 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 11 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00003709 | Chemotherapy in Treating Patients With Advanced Solid Tumors | neoplasm | Carbendazim (NPC42483) | NP level |
| NCT00023816 | Carbendazim in Treating Patients With Advanced Solid Tumors or Lymphoma | lymphoma | Carbendazim (NPC42483) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Eucalyptol (NPC287331) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Camphor (NPC131981) | NP level |
| NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | NP level |
| NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | NP level |
| NCT02944552 | The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI | injury | Bicyclol (NPC474770) | NP level |
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
| NCT05063500 | The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI | injury | Bicyclol (NPC474770) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
HTR2B
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
HTR7,DRD1,HTR2B,CNR2,LMNA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HTR6,HTR7,HTR1A,MAPT
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT01659580,NCT02029118
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
HTR6,HTR1A
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
