CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Dovyalis Hebecarpa

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO29086
Plant Latin Name: Dovyalis Hebecarpa
Taxonomy Genus: Dovyalis
Taxonomy Family: Salicaceae

Plant External Links:

NCBI TaxonomyDB: 688332
Plant-of-the-World-Online: 111561-1

Used in Medicines

Unknown.

Geographical Distribution

Sri Lanka; United States; Dominican Republic; Cuba

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

22 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

22 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

13 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC7467

Ingredient ID: NPC7018

Ingredient ID: NPC69786

Ingredient ID: NPC31930

Ingredient ID: NPC305910

Ingredient ID: NPC249797

Ingredient ID: NPC216459

Ingredient ID: NPC207757

Ingredient ID: NPC205421

Ingredient ID: NPC204828

Ingredient ID: NPC202771

Ingredient ID: NPC19386

Ingredient ID: NPC187100

Ingredient ID: NPC163436

Ingredient ID: NPC158376

Ingredient ID: NPC157504

Ingredient ID: NPC156372

Ingredient ID: NPC152609

Ingredient ID: NPC130391

Ingredient ID: NPC117188

Ingredient ID: NPC114364

Ingredient ID: NPC106295

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450	Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD5	Dopamine D5 receptor	P21918	CHEMBL1850
Therapeutic Target	Surface antigen	F3	Coagulation factor III	P13726	CHEMBL4081

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	4

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00912899	A Study of Noscapine HCl (CB3304 ) in Patients With Relapsed or Refractory Multiple Myeloma	multiple myeloma	Noscapine (NPC202771)	NP level
NCT01631383	Pharmacokinetic and Safety Evaluation of L-tetrahydropalmatine (l-THP) With Cocaine Exposure in People With a History of Cocaine Use	cocaine dependence	Tetrahydropalmatine (NPC210437)	NP level
NCT02139761	L-tetrahydropalmatine (l-THP) Treatment for Cocaine Use Disorder	cocaine dependence	Tetrahydropalmatine (NPC210437)	NP level
NCT00183950	Study of Noscapine for Patients With Low Grade Non Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia Refractory to Chemotherapy	chronic lymphocytic leukemia	Noscapine (NPC202771)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	DRD2,DRD4,DRD3,DRD1
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	DRD4,DRD3,DRD1,DRD2
Allergic/hypersensitivity disorder Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A80-4A8Z	DRD1,DRD4,DRD2,DRD5
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	DRD1,CYP2C19,CYP2C9,DRD2
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	DRD3,F3,DRD2
Depression Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A70-6A7Z	DRD3,DRD2,DRD4
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	DRD2,DRD1,DRD2
Multiple myeloma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A83	DRD3,DRD2 NCT00912899
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	DRD2,DRD3,DRD4
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	DRD2,DRD3,DRD4
Psychotic disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20-6A25	DRD4,DRD1,DRD2
Bipolar disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A60	DRD3,DRD4,DRD2
Cocaine use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C45	DRD1 NCT02139761,NCT01631383
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	CYP2C9,DRD2,DRD4
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CYP2C19,CYP2C9,DRD2
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	DRD1,CYP2C9,DRD2
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	DRD2,DRD3
Endometrial cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76	DRD3,DRD2
Stomach cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	DRD2,DRD3
Pancreatic cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	F3,DRD2
Acute upper respiratory infection Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA07	DRD3,DRD2
BCR-ABL1-negative chronic myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A41	DRD2,DRD3
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CYP2D6,DRD2
Mature T-cell lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A90	DRD3,DRD2
Gastroduodenal motor/secretory disorder Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA41	DRD2,DRD3
Sexual dysfunction Disease Category: 17.Conditions related to sexual health Disease ICD-11 Code: HA00-HA01	DRD2,DRD3
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	DRD5,DRD2
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	DRD5,DRD2
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	DRD4,F3
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	DRD5,DRD4
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	CYP2C9,DRD4
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	DRD1,DRD2
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	F3,DRD2
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	CYP2C9,CYP2D6
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	CYP2C9,CYP2D6
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	DRD1,CYP2C9
Faecal incontinence Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: ME07	DRD2
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	DRD2
Inborn porphyrin/heme metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C58	DRD2
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	DRD2
Psychoactive substances use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C4G	DRD3
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	DRD2
Idiopathic interstitial pneumonitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03	DRD2
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	DRD2
Tic disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A05	DRD1
Heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10-BD1Z	DRD2
Itching Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F28-1G07	DRD2
Carcinoid syndrome Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B10	DRD2
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	DRD2
Breathing abnormality Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD11	DRD2
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	DRD2
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	DRD2
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	DRD2
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	F3
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CYP2C9
NA Disease Category: NA Disease ICD-11 Code: NA	DRD2
Thyrotoxicosis Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A02	DRD2
Chronic kidney disease Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB61	DRD2
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	DRD2
Restless legs syndrome Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A80	DRD2
Malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F40-1F45	CYP2D6
Nasopharyngeal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B6B	DRD3
Hyperaemia Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9A61-9B7Y	DRD2
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	DRD1
Digestive system disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DE2Z	DRD2
Endocrine gland neoplasm Disease Category: 02.Neoplasms Disease ICD-11 Code: 2F37	DRD2
Intellectual development disorder Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LD90	DRD2
Pituitary gland disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A60-5A61	DRD2
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	DRD2
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	DRD2
Cerebral ischaemia Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B1Z	DRD2
Bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20-GA21	F3
Schizoaffective disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A21	DRD2
Gangrene Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MC85	DRD2
Hypotension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA20-BA21	DRD2
Migraine Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A80	DRD2
Substance abuse Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40	DRD2
Postpartum haemorrhage Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA43	DRD2
Abortion Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA00	DRD1
Essential hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00	DRD2
Chronic lymphocytic leukaemia or small lymphocytic lymphoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A82.0	NCT00183950
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	DRD5
Myelodysplastic syndromes, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A3Z	CYP2C9
Dengue fever, unspecified Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D2Z	DRD3
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	DRD5
Idiopathic pulmonary fibrosis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03.4	DRD5
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	DRD1
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	F3
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	F3
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	DRD2
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	DRD4
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CYP2C9
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	F3
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	DRD2

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Dovyalis Hebecarpa

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

22 All known Ingredients in Total

22 Ingredients with Acceptable Bioavailablity

13 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Schizophrenia

Parkinsonism

Allergic/hypersensitivity disorder

Adenocarcinoma of pancreas

Solid tumour/cancer

Depression

Pulmonary hypertension

Multiple myeloma

Alzheimer disease

Attention deficit hyperactivity disorder

Psychotic disorder

Bipolar disorder

Cocaine use disorder

Squamous cell carcinoma of bronchus or lung

Cytomegaloviral disease

Malignant neoplasms of thymus

Brain cancer

Endometrial cancer

Stomach cancer

Pancreatic cancer

Acute upper respiratory infection

BCR-ABL1-negative chronic myeloid leukaemia

Insomnia

Mature T-cell lymphoma

Gastroduodenal motor/secretory disorder

Sexual dysfunction

Serous cystadenoma,borderline malignancy of ovary

Pheochromocytoma

Malignant neoplasms of biliary tract, distal bile duct

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Other specified malignant neoplasms of kidney, except renal pelvis

Mesothelioma of pleura

Systemic lupus erythematosus

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Germ cell tumour of testis

Faecal incontinence

Psoriasis

Inborn porphyrin/heme metabolism error

Cardiovascular disease

Psychoactive substances use disorder

Anxiety

Idiopathic interstitial pneumonitis

Choreiform disorder

Tic disorder

Heart failure

Itching

Carcinoid syndrome

General pain disorder

Breathing abnormality

Glaucoma

Type 2 diabetes mellitus

Pain, unspecified

Acute respiratory distress syndrome

Bacterial infection

NA

Thyrotoxicosis

Chronic kidney disease

Lung cancer

Restless legs syndrome

Malaria

Nasopharyngeal cancer

Hyperaemia

Dementia