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Collective Molecular Activities of the Plant: Leptactina Senegambica


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO2906
Plant Latin Name: Leptactina Senegambica
Taxonomy Genus: Leptactina
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

39 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


22 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

10 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC97420

Ingredient ID: NPC96010

Ingredient ID: NPC95535

Ingredient ID: NPC94310

Ingredient ID: NPC93279

Ingredient ID: NPC91604

Ingredient ID: NPC89636

Ingredient ID: NPC87123

Ingredient ID: NPC70215

Ingredient ID: NPC616

Ingredient ID: NPC56912

Ingredient ID: NPC53410

Ingredient ID: NPC44430

Ingredient ID: NPC40488

Ingredient ID: NPC40034

Ingredient ID: NPC33392

Ingredient ID: NPC311830

Ingredient ID: NPC311310

Ingredient ID: NPC310323

Ingredient ID: NPC300434

Ingredient ID: NPC297989

Ingredient ID: NPC292452

Ingredient ID: NPC286405

Ingredient ID: NPC28280

Ingredient ID: NPC25089

Ingredient ID: NPC246834

Ingredient ID: NPC240216

Ingredient ID: NPC234502

Ingredient ID: NPC232734

Ingredient ID: NPC223217

Ingredient ID: NPC210003

Ingredient ID: NPC189142

Ingredient ID: NPC176012

Ingredient ID: NPC161571

Ingredient ID: NPC136073

Ingredient ID: NPC128842

Ingredient ID: NPC102854

Ingredient ID: NPC101378

Ingredient ID: NPC100159

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Therapeutic Target Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Therapeutic Target Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Therapeutic Target Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Therapeutic Target Nuclear hormone receptor subfamily 3 ESR1 Estrogen receptor alpha P03372 CHEMBL206
Therapeutic Target Oxidoreductase NQO2 Quinone reductase 2 P16083 CHEMBL3959
Therapeutic Target Oxidoreductase PTGS2 Cyclooxygenase-2 P35354 CHEMBL230
Therapeutic Target Serine protease DPP4 Dipeptidyl peptidase IV P27487 CHEMBL284
Therapeutic Target Smoothened receptor (frizzled family GPCR) SMO Smoothened homolog Q99835 CHEMBL5971
Therapeutic Target Transferase PIK3CA PI3-kinase p110-alpha subunit P42336 CHEMBL4005
Therapeutic Target Transferase PIK3CB PI3-kinase p110-beta subunit P42338 CHEMBL3145
Therapeutic Target Transient receptor potential channel TRPA1 Transient receptor potential cation channel subfamily A member 1 O75762 CHEMBL6007
Therapeutic Target Unclassified protein SHH Sonic hedgehog protein Q15465 CHEMBL5602
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level45
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT02314208 Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 Spastic paraplegia Resveratrol (NPC161571) NP level
NCT01504854 Resveratrol for Alzheimer's Disease Alzheimer disease Resveratrol (NPC161571) NP level
NCT04867252 Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome polycystic ovary syndrome Resveratrol (NPC161571) NP level
NCT01677611 Effects of Resveratrol in Patients With Type 2 Diabetes type 2 diabetes mellitus Resveratrol (NPC161571) NP level
NCT04449198 Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1 type 1 diabetes mellitus Resveratrol (NPC161571) NP level
NCT02245932 Resveratrol In Chronic Obstructive Pulmonary Disease (COPD) Patients (CARMENS-trial) chronic obstructive pulmonary disease Resveratrol (NPC161571) NP level
NCT02030977 The Effects of Resveratrol Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Steatohepatitis non-alcoholic fatty liver disease Resveratrol (NPC161571) NP level
NCT03743636 Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease peripheral arterial disease Resveratrol (NPC161571) NP level
NCT04400890 Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19 COVID-19 Resveratrol (NPC161571) NP level
NCT00433576 Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery colorectal adenocarcinoma;malignant colon neoplasm;rectum cancer Resveratrol (NPC161571) NP level
NCT02433925 Resveratrol's Effects on Inflammation and Oxidative Stress in Chronic Kidney Disease chronic kidney disease Resveratrol (NPC161571) NP level
NCT01914081 Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside dilated cardiomyopathy Resveratrol (NPC161571) NP level
NCT01339884 A Study of Resveratrol as Treatment for Friedreich Ataxia Friedreich ataxia Resveratrol (NPC161571) NP level
NCT03446625 Resveratrol as a Preventive Treatment of OHSS infertility Resveratrol (NPC161571) NP level
NCT03091543 Tolerability, Safety and Pharmacokinetics of Four Single-doses of BIA 6-512 (Trans-resveratrol) and Their Effect on the Levodopa Pharmacokinetics Parkinson disease Resveratrol (NPC161571) NP level
NCT01842399 Resveratrol and Cardiovascular Health in the Elderly hypertension Resveratrol (NPC161571) NP level
NCT02219906 Resveratrol in Metabolic Syndrome: Effect on Platelet Hyper-reactivity and HDL Lipid Peroxidation metabolic syndrome Resveratrol (NPC161571) NP level
NCT05062486 A Study to Evaluate the Safety and Efficacy of RQC for AMD age-related macular degeneration Resveratrol (NPC161571) NP level
NCT03093389 Tolerability and Steady-state Pharmacokinetics of BIA 6-512 Parkinson disease Resveratrol (NPC161571) NP level
NCT03094156 Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics Parkinson disease Resveratrol (NPC161571) NP level
NCT03091868 Pharmacokinetics of Rising Single-doses of BIA 6-512 and Their Effect on the Levodopa Pharmacokinetics Parkinson disease Resveratrol (NPC161571) NP level
NCT01492114 Anti-inflammatory and Antioxidant Effects of Resveratrol on Healthy Adults. inflammation Resveratrol (NPC161571) NP level
NCT02062190 Resveratrol, Cardiovascular Risk Markers And Cognitive Performance In Patients With Schizophrenia schizophrenia Resveratrol (NPC161571) NP level
NCT02523274 Resveratrol and Exercise to Treat Functional Limitations in Late Life aging Resveratrol (NPC161571) NP level
NCT00654667 Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome insulin resistance Resveratrol (NPC161571) NP level
NCT01321151 Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers concussion Resveratrol (NPC161571) NP level
NCT03095092 Effect of Food on BIA 6-512 (Trans-resveratrol) Parkinson disease Resveratrol (NPC161571) NP level
NCT00455416 Dietary Intervention in Follicular Lymphoma follicular lymphoma Resveratrol (NPC161571) NP level
NCT00256334 Resveratrol for Patients With Colon Cancer malignant colon neoplasm Resveratrol (NPC161571) NP level
NCT02261844 Resveratrol and Human Hepatocyte Function in Cancer liver cancer Resveratrol (NPC161571) NP level
NCT01564381 Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women cardiovascular disease Resveratrol (NPC161571) NP level
NCT02704494 Resveratrol's Effects in Diabetic Nephropathy diabetic nephropathy Resveratrol (NPC161571) NP level
NCT00098969 UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants neoplasm Resveratrol (NPC161571) NP level
NCT01126229 Resveratrol for Improved Performance in the Elderly memory impairment Resveratrol (NPC161571) NP level
NCT02336633 Resveratrol and Huntington Disease Huntington disease Resveratrol (NPC161571) NP level
NCT02130440 Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis seasonal allergic rhinitis Resveratrol (NPC161571) NP level
NCT02905799 Resveratrol in Knee Osteoarthritis osteoarthritis Resveratrol (NPC161571) NP level
NCT02409537 Effects of Dietary Antioxidants to Prevent Cardiovascular Disease Hypercholesterolemia Resveratrol (NPC161571) NP level
NCT04542993 Can SARS-CoV-2 Viral Load and COVID-19 Disease Severity be Reduced by Resveratrol-assisted Zinc Therapy COVID-19;severe acute respiratory syndrome Resveratrol (NPC161571) NP level
NCT02549924 Effect of Administration of Resveratrol on Glycemic Variability in Individuals With Type 2 Diabetes Mellitus type 2 diabetes mellitus Resveratrol (NPC161571) NP level
NCT03933163 Micronised Resveratrol as a Treatment for Friedreich Ataxia Friedreich ataxia Resveratrol (NPC161571) NP level
NCT03095105 Pharmacokinetic Profile of BIA 6-512 in Healthy Elderly Subjects Versus Healthy Young Subjects Parkinson disease Resveratrol (NPC161571) NP level
NCT02114892 Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion metabolic syndrome Resveratrol (NPC161571) NP level
NCT03097211 Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg Parkinson disease Resveratrol (NPC161571) NP level
NCT03253913 Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial lymphangioleiomyomatosis Resveratrol (NPC161571) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Parkinsonism
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00
 PTGS2,PTGS1
 NCT03091868,NCT03095105,NCT03093389,NCT03091543,NCT03095092,NCT03094156,NCT03097211
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 DPP4,CA14,LMNA,TRPA1,PTGS2,PTGS1,CA9,SHH,CYP1B1
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 DPP4,CA12,LMNA,SMO,TRPA1,TYR,PTGS1,CA9
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 DPP4,CA12,CA14,SMO,TRPA1,PIK3CB,PTGS1,SHH
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 PIK3CB,CA9,PIK3CA,NQO2,ESR1,CA12,CA14
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 DPP4,CA14,TRPA1,PTGS2,PTGS1,CA9,SHH
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 DPP4,CA12,LMNA,PTGS2,PTGS1,CA9,CYP1B1
Type 2 diabetes mellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A11
 PTGS2,PTGS1,DPP4
 NCT02549924,NCT01677611
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 CA12,PIK3CB,ESR1,CA9,SHH
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 CA12,LMNA,SMO,TRPA1,CA9
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 TRPA1,TYR,CA9,TRPA1,CA9
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 CA12,CA9,CA12,SMO,CA9
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 DPP4,CYP3A4,TRPA1,CYP1B1,CA9
Invasive carcinoma of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C61
 CA12,TRPA1,ESR1,CA9,SHH
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 LMNA,TRPA1,PTGS1,CA9
Squamous cell carcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.2
 CA12,SMO,TRPA1,CA9
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 DPP4,LMNA,NQO2,PTGS2
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 DPP4,CA12,CYP1B1,SHH
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 DPP4,TRPA1,ESR1,CYP1B1
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 DPP4,CYP3A4,CA12,CA9
Female pelvic pain
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA34
 PTGS1,PTGS2,ESR1
Endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10
 ESR1,PTGS1,PTGS2
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 PIK3CB,PIK3CA,ESR1
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 PTGS1,PTGS2
 NCT01504854
Osteoarthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA00-FA05
 PTGS2,PTGS1
 NCT02905799
Pain, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG3Z
 PTGS1,PTGS2,PIK3CB
Cardiovascular disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00-BE2Z
 PTGS2,PTGS1
 NCT01564381
Hyper-lipoproteinaemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80
 ESR1,PTGS2,PTGS1
Colorectal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B91
 PTGS1,PIK3CB,PIK3CA
Myocardial infarction
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA41-BA43
 PTGS1,PTGS2,DPP4
Atopic eczema
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA80
 PTGS1,CYP3A4,PTGS2
Metabolic disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C50-5D2Z
 DPP4
 NCT02219906,NCT02114892
Malignant neoplasm metastasis in lymph nodes of head, face or neck
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60.0
 TRPA1,PTGS2,CA9
Other specified malignant neoplasms ofcolon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 TYR,CA9,SHH
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 CA14,PIK3CB,SHH
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 CA12,TRPA1,CA9
Brain cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00
 SMO,ESR1
Postoperative inflammation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-CA43
 PTGS2,PTGS1
Malignant haematopoietic neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B33
 PIK3CA,DPP4
Joint pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME82
 PTGS1,PTGS2
Cerebral ischaemia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B1Z
 PTGS1,PTGS2
Spinal pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME84
 PTGS1,PTGS2
Seborrhoeic dermatitis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA81
 PTGS1,CA12
Follicular lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A80
 PIK3CA
 NCT00455416
Diabetes mellitus, type unspecified
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A14
 DPP4,ESR1
Indeterminate colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD72
 PTGS1,PTGS2
HIV-infected patients with tuberculosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1B10-1B14
 PTGS1,PTGS2
Rheumatoid arthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA20
 PTGS1,PTGS2
Migraine
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A80
 PTGS1,PTGS2
Urinary system disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GC2Z
 PTGS2,PTGS1
Otitis media
Disease Category: 10.Diseases of the ear or mastoid process
Disease ICD-11 Code: AA80-AB0Z
 PTGS2,PTGS1
Neuropathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C0Z
 PTGS1,TRPA1
Reactive arthropathy
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA11
 PTGS1,PTGS2
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 CA12,CA14
Male infertility
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB04
 ESR1
 NCT03446625
Inflammatory spondyloarthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA92
 PTGS1,PTGS2
Inherited coagulation factor deficiency
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B14
 PTGS2,PTGS1
Friedreich ataxia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A03.10
 NCT01339884,NCT03933163
Malignant neoplasms of colon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 NCT00433576,NCT00256334
COVID-19
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D6Y
 NCT04400890,NCT04542993
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 CA14,PTGS1
Osteoarthritis, unspecified
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA0Z
 CA12,TRPA1
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 DPP4,TRPA1
West Nile virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D46
 DPP4,PTGS2
Pneumonia due to Pseudomonasaeruginosa
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA40.05
 DPP4,TRPA1
Other specified malignant neoplasms of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.Y
 CA12,CA9
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 CYP3A4,CA9
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 CA9,SHH
Heart failure, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD1Z
 CYP1B1,PTGS2
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 CA12,CYP3A4
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 NQO2,PTGS2,CA12,PIK3CB,CA9,CYP3A4,PIK3CA,PTGS1,SMO,ESR1,CA14
Menstrual cycle bleeding disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA20
 ESR1
Menopausal disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA30
 ESR1
Female genital tract noninflammatory disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA1Y
 ESR1
Ulcerative colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD71
 PTGS1
Acne vulgaris
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED80
 ESR1
Vaginitis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA02
 ESR1
Melanoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 TYR
Asthma
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA23
 PTGS2
Renal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90
 CA9
Muscular dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C70
 PTGS1
Chronic arterial occlusive disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD4Z
 DPP4
Acquired prion disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E01
 ESR1
Psoriasis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA90
 DPP4
Upper respiratory tract disorder
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0Z
 TRPA1
Basal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C32
 SMO
Acquired hypermelanosis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED60
 TYR
Breast in situ carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E65
 ESR1
Systemic sclerosis
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A42
 PTGS1
Metastatic tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D50-2E2Z
 ESR1
Acute diabete complication
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A2Y
 DPP4
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 CA9
Ovarian cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73
 SMO
Pituitary gland disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A60-5A61
 ESR1
Skin cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30-2C37
 SMO
Ataxic disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A03
 PTGS1
Dyspareunia
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA12
 ESR1
Skeletal anomaly
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD24
 ESR1
Low bone mass disorder
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83
 ESR1
Knee osteoarthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA01
 PTGS2
Chronic myelomonocytic leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A40
 SMO
Acquired hypomelanotic disorder
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED63
 TYR
Adrenal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 ESR1
Inborn metabolism deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C50-5C59
 CA14
Metastatic lymph node neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60
 PIK3CB
Vasculitis
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A44
 PTGS1
Female infertility
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA31
 ESR1
Autism spectrum disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A02
 DPP4
Insomnia
Disease Category: 07.Sleep-wake disorders
Disease ICD-11 Code: 7A00-7A0Z
 NQO2
Anxiety
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB24.3
 CYP3A4
Chronic pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30
 PTGS2
Multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40
 ESR1
Nutritional deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B50-5B71
 PTGS1
Unspecified viral infection of unspecified site
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D9Z
 ESR1
Eye anterior segment structural developmental anomaly
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA11
 PTGS1
Severe acute respiratory syndrome
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D65
 NCT04542993
Rectum cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B92
 NCT00433576
Non-alcoholic fatty liver disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB92
 NCT02030977
Polycystic ovary syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A80.1
 NCT04867252
Huntington disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A01.10
 NCT02336633
Chronic arterial occlusive disease, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD4Z
 NCT03743636
Macular degeneration
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B75
 NCT05062486
Concussion
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NA07.0
 NCT01321151
Insulin-resistance syndromes
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A44
 NCT00654667
Ageing associated decline in intrinsic capacity
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG2A
 NCT02523274
Type1diabetesmellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A10
 NCT04449198
Other specified malignant neoplasms of colon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 NCT00433576
Neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 02
 NCT00098969
Vasomotor/allergic rhinitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA08
 NCT02130440
Lymphangioleiomyomatosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB07
 NCT03253913
Paraplegia
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB56
 NCT02314208
Cardiomyopathy
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC43
 NCT01914081
Chronic obstructive pulmonary disease
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA22
 NCT02245932
NA
Disease Category: NA
Disease ICD-11 Code: NA
 NCT01492114
Chronic kidney disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61
 NCT02433925
Schizophrenia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A20
 NCT02062190
Pulmonary hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BB01
 NCT01842399
Age-associated cognitive decline
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB21.0
 NCT01126229
Hypercholesterolaemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80.0
 NCT02409537
Liver cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12
 NCT02261844
Chronic kidney disease, stage unspecified
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61.Z
 NCT02704494
Crohn disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD70
 PTGS2
Non-alcoholic steatohepatitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB92.1
 PTGS2
Myelodysplastic syndromes, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A3Z
 SHH
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 CA12
Malignant neoplasms of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94
 PTGS2
Tetralogy of Fallot
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA88.2
 CA14
Chronic rhinosinusitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0A
 CA9
Systemic lupus erythematosus
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A40.0
 SMO
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 LMNA
Human immunodeficiency virus disease without mention of tuberculosis or malaria
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62
 PTGS2
Gliomas of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.0
 PTGS1

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
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chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
dyhou22@m.fudan.edu.cn
Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
yhfeng22@m.fudan.edu.cn

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