Collective Molecular Activities of the Plant: Piper Nigrum
Country/Region:
Brazil; Philippines; Indonesia; India; United States; China; Thailand; Iraq; Burkina FasoTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; HomeopathyBrazil; Bangladesh; Guinea; Costa Rica; Cambodia; Cameroon; Burkina Faso; Benin; Cuba; Venezuela; China; Thailand; Haiti; Iraq; Philippines; Indonesia; Mauritius; Trinidad and Tobago; French Guiana; Dominican Republic; United States; Seychelles; Honduras; Mexico; India; Sri Lanka
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
291 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
233 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
162 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99830
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Ingredient ID: NPC78551
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Ingredient ID: NPC112890
Ingredient ID: NPC109813
Ingredient ID: NPC108494
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Ingredient ID: NPC103700
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Ingredient ID: NPC100879
Ingredient ID: NPC100082
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | Potassium channels | KCNH2 | HERG | Q12809 | CHEMBL240 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 917 | |
 Plant level | 2 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000120 | Clinical Trial of Eye Prophylaxis in the Newborn | Chlamydia trachomatis infectious disease | Erythromycin (NPC227622) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000437 | Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00000444 | Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch) | nicotine dependence | Nicotine (NPC182570) | NP level |
| NCT00000447 | Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) | nicotine dependence | Nicotine (NPC182570) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
ADRB3
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
NCT03522922,NCT03090048 |
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
ADRB3,NR3C1,HTR2C,ADRB1,PPARA,FFAR1,HTR2A
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
NCT01842139,NCT00329498,NCT00184054,NCT02472626 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG31 |
SLC6A2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
