Collective Molecular Activities of the Plant: Scutellaria Baicalensis
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCM; KampoMedicinal Functions:
Anodyne; Antibacterial; Anticholesterolemic; Antipyretic; Antispasmodic; Astringent; Cancer; Cholagogue; Diuretic; Expectorant; Febrifuge; Haemostatic; Laxative; Nervine; Sedative; Stomachic; TB; Tonic
South Africa; Mongolia; Vietnam; China; South Korea; Russia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
161 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
111 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
65 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95676
Ingredient ID: NPC94304
Ingredient ID: NPC94218
Ingredient ID: NPC94045
Ingredient ID: NPC93033
Ingredient ID: NPC92659
Ingredient ID: NPC90787
Ingredient ID: NPC88072
Ingredient ID: NPC86433
Ingredient ID: NPC85813
Ingredient ID: NPC85327
Ingredient ID: NPC82648
Ingredient ID: NPC82363
Ingredient ID: NPC81775
Ingredient ID: NPC79527
Ingredient ID: NPC78540
Ingredient ID: NPC76145
Ingredient ID: NPC70744
Ingredient ID: NPC70136
Ingredient ID: NPC66700
Ingredient ID: NPC649
Ingredient ID: NPC62086
Ingredient ID: NPC61307
Ingredient ID: NPC6119
Ingredient ID: NPC61104
Ingredient ID: NPC60669
Ingredient ID: NPC59303
Ingredient ID: NPC5708
Ingredient ID: NPC55612
Ingredient ID: NPC54626
Ingredient ID: NPC50898
Ingredient ID: NPC4827
Ingredient ID: NPC45618
Ingredient ID: NPC44659
Ingredient ID: NPC43212
Ingredient ID: NPC43211
Ingredient ID: NPC4125
Ingredient ID: NPC3922
Ingredient ID: NPC3649
Ingredient ID: NPC3190
Ingredient ID: NPC318235
Ingredient ID: NPC312391
Ingredient ID: NPC311629
Ingredient ID: NPC311343
Ingredient ID: NPC306821
Ingredient ID: NPC306616
Ingredient ID: NPC306607
Ingredient ID: NPC306462
Ingredient ID: NPC302857
Ingredient ID: NPC301323
Ingredient ID: NPC299529
Ingredient ID: NPC296197
Ingredient ID: NPC294852
Ingredient ID: NPC293183
Ingredient ID: NPC284819
Ingredient ID: NPC284498
Ingredient ID: NPC281994
Ingredient ID: NPC280717
Ingredient ID: NPC27794
Ingredient ID: NPC277467
Ingredient ID: NPC275124
Ingredient ID: NPC274909
Ingredient ID: NPC270074
Ingredient ID: NPC269806
Ingredient ID: NPC268533
Ingredient ID: NPC266021
Ingredient ID: NPC26583
Ingredient ID: NPC265513
Ingredient ID: NPC264735
Ingredient ID: NPC262253
Ingredient ID: NPC261831
Ingredient ID: NPC261619
Ingredient ID: NPC259713
Ingredient ID: NPC259706
Ingredient ID: NPC258723
Ingredient ID: NPC257522
Ingredient ID: NPC25676
Ingredient ID: NPC254976
Ingredient ID: NPC249045
Ingredient ID: NPC249018
Ingredient ID: NPC243601
Ingredient ID: NPC239312
Ingredient ID: NPC237435
Ingredient ID: NPC237002
Ingredient ID: NPC235165
Ingredient ID: NPC231772
Ingredient ID: NPC229403
Ingredient ID: NPC225406
Ingredient ID: NPC225284
Ingredient ID: NPC224462
Ingredient ID: NPC223417
Ingredient ID: NPC222830
Ingredient ID: NPC219573
Ingredient ID: NPC215702
Ingredient ID: NPC214138
Ingredient ID: NPC213322
Ingredient ID: NPC213216
Ingredient ID: NPC210094
Ingredient ID: NPC20892
Ingredient ID: NPC207869
Ingredient ID: NPC207725
Ingredient ID: NPC206380
Ingredient ID: NPC202691
Ingredient ID: NPC200855
Ingredient ID: NPC197378
Ingredient ID: NPC197316
Ingredient ID: NPC196776
Ingredient ID: NPC194383
Ingredient ID: NPC186653
Ingredient ID: NPC18511
Ingredient ID: NPC183953
Ingredient ID: NPC183878
Ingredient ID: NPC181912
Ingredient ID: NPC181582
Ingredient ID: NPC180612
Ingredient ID: NPC178859
Ingredient ID: NPC17458
Ingredient ID: NPC174493
Ingredient ID: NPC173658
Ingredient ID: NPC170526
Ingredient ID: NPC170070
Ingredient ID: NPC169454
Ingredient ID: NPC167976
Ingredient ID: NPC166894
Ingredient ID: NPC164086
Ingredient ID: NPC163424
Ingredient ID: NPC158151
Ingredient ID: NPC157923
Ingredient ID: NPC156953
Ingredient ID: NPC153830
Ingredient ID: NPC15292
Ingredient ID: NPC152280
Ingredient ID: NPC149570
Ingredient ID: NPC149487
Ingredient ID: NPC149203
Ingredient ID: NPC148677
Ingredient ID: NPC147628
Ingredient ID: NPC143894
Ingredient ID: NPC142871
Ingredient ID: NPC142703
Ingredient ID: NPC142540
Ingredient ID: NPC137167
Ingredient ID: NPC136745
Ingredient ID: NPC135602
Ingredient ID: NPC131624
Ingredient ID: NPC130230
Ingredient ID: NPC127661
Ingredient ID: NPC127447
Ingredient ID: NPC125962
Ingredient ID: NPC124853
Ingredient ID: NPC124478
Ingredient ID: NPC121886
Ingredient ID: NPC121270
Ingredient ID: NPC120464
Ingredient ID: NPC119508
Ingredient ID: NPC114239
Ingredient ID: NPC112394
Ingredient ID: NPC111897
Ingredient ID: NPC110661
Ingredient ID: NPC105380
Ingredient ID: NPC100178
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Therapeutic Target | Cysteine protease | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 28 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00854724 | Puerarin Effects on Alcohol Drinking | alcohol abuse | Puerarin (NPC124478) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
| NCT01690676 | Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function | hypertension | (+)-Epicatechin (NPC261619) | NP level |
| NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,MGAM,AKR1B1,PPARA,FFAR1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CDK8,TP53,CDK9
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
THPO,CA7,XDH,CBR1,AKR1C3,TTR,ACHE,CA12
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
MAOB,ACHE,CYP2C19,CA7,LMNA,ABCB1,XDH,TUBB6,HIF1A,FFAR4,FABP3,AKR1C3,CYP1B1,SNCA,MGAM,CBR1,TTR,DPP4,ALOX15
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,TTR,ALOX15
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP19A1,ALOX15
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ESR2,MAOA,SNCA,ACHE,MAOB
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
TTR
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
