Collective Molecular Activities of the Plant: Annona Squamosa
Plant ID: NPO2884
Plant Latin Name: Annona Squamosa
Taxonomy Genus: Annona
Taxonomy Family: Annonaceae
Plant External Links:
NCBI TaxonomyDB:
301693
Plant-of-the-World-Online:
n.a.
Country/Region:
Ghana; United States; Indonesia; India; ChinaTraditional Medicine System:
Indian Folk; TCM; Unani; Ayurveda; SiddhaGhana; India; Indonesia; China; United States
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
175 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
123 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
111 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97221
Ingredient ID: NPC94875
Ingredient ID: NPC94167
Ingredient ID: NPC93063
Ingredient ID: NPC90875
Ingredient ID: NPC89709
Ingredient ID: NPC88372
Ingredient ID: NPC81247
Ingredient ID: NPC78284
Ingredient ID: NPC77871
Ingredient ID: NPC77250
Ingredient ID: NPC73310
Ingredient ID: NPC73195
Ingredient ID: NPC69445
Ingredient ID: NPC6678
Ingredient ID: NPC64466
Ingredient ID: NPC63190
Ingredient ID: NPC61257
Ingredient ID: NPC58785
Ingredient ID: NPC57036
Ingredient ID: NPC55412
Ingredient ID: NPC53978
Ingredient ID: NPC51843
Ingredient ID: NPC51249
Ingredient ID: NPC489907
Ingredient ID: NPC488234
Ingredient ID: NPC480086
Ingredient ID: NPC480071
Ingredient ID: NPC477919
Ingredient ID: NPC476583
Ingredient ID: NPC47604
Ingredient ID: NPC475206
Ingredient ID: NPC473478
Ingredient ID: NPC46419
Ingredient ID: NPC43205
Ingredient ID: NPC428
Ingredient ID: NPC39754
Ingredient ID: NPC39279
Ingredient ID: NPC38694
Ingredient ID: NPC37272
Ingredient ID: NPC329838
Ingredient ID: NPC329829
Ingredient ID: NPC329615
Ingredient ID: NPC328447
Ingredient ID: NPC326683
Ingredient ID: NPC320458
Ingredient ID: NPC319036
Ingredient ID: NPC318963
Ingredient ID: NPC318151
Ingredient ID: NPC313513
Ingredient ID: NPC312025
Ingredient ID: NPC308412
Ingredient ID: NPC305952
Ingredient ID: NPC304659
Ingredient ID: NPC302274
Ingredient ID: NPC298449
Ingredient ID: NPC297670
Ingredient ID: NPC293136
Ingredient ID: NPC292809
Ingredient ID: NPC291631
Ingredient ID: NPC291154
Ingredient ID: NPC28928
Ingredient ID: NPC285913
Ingredient ID: NPC28425
Ingredient ID: NPC278683
Ingredient ID: NPC278525
Ingredient ID: NPC276674
Ingredient ID: NPC27349
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC268736
Ingredient ID: NPC267033
Ingredient ID: NPC26421
Ingredient ID: NPC261952
Ingredient ID: NPC261420
Ingredient ID: NPC261012
Ingredient ID: NPC260118
Ingredient ID: NPC259682
Ingredient ID: NPC258695
Ingredient ID: NPC258068
Ingredient ID: NPC25764
Ingredient ID: NPC254762
Ingredient ID: NPC253331
Ingredient ID: NPC253043
Ingredient ID: NPC252503
Ingredient ID: NPC252032
Ingredient ID: NPC250532
Ingredient ID: NPC248920
Ingredient ID: NPC247785
Ingredient ID: NPC244968
Ingredient ID: NPC244606
Ingredient ID: NPC24264
Ingredient ID: NPC242364
Ingredient ID: NPC240343
Ingredient ID: NPC24019
Ingredient ID: NPC24014
Ingredient ID: NPC239509
Ingredient ID: NPC239406
Ingredient ID: NPC237203
Ingredient ID: NPC237188
Ingredient ID: NPC235809
Ingredient ID: NPC233334
Ingredient ID: NPC23219
Ingredient ID: NPC232151
Ingredient ID: NPC230170
Ingredient ID: NPC22928
Ingredient ID: NPC22485
Ingredient ID: NPC22481
Ingredient ID: NPC222561
Ingredient ID: NPC220858
Ingredient ID: NPC219875
Ingredient ID: NPC219753
Ingredient ID: NPC219498
Ingredient ID: NPC219170
Ingredient ID: NPC215747
Ingredient ID: NPC210434
Ingredient ID: NPC210296
Ingredient ID: NPC210218
Ingredient ID: NPC207786
Ingredient ID: NPC205421
Ingredient ID: NPC205312
Ingredient ID: NPC203468
Ingredient ID: NPC202605
Ingredient ID: NPC19722
Ingredient ID: NPC196197
Ingredient ID: NPC195749
Ingredient ID: NPC195075
Ingredient ID: NPC193949
Ingredient ID: NPC191632
Ingredient ID: NPC191213
Ingredient ID: NPC189470
Ingredient ID: NPC188822
Ingredient ID: NPC187770
Ingredient ID: NPC184026
Ingredient ID: NPC180363
Ingredient ID: NPC180253
Ingredient ID: NPC180199
Ingredient ID: NPC17810
Ingredient ID: NPC176484
Ingredient ID: NPC17599
Ingredient ID: NPC171658
Ingredient ID: NPC167400
Ingredient ID: NPC166014
Ingredient ID: NPC165098
Ingredient ID: NPC164892
Ingredient ID: NPC161187
Ingredient ID: NPC160298
Ingredient ID: NPC159938
Ingredient ID: NPC159750
Ingredient ID: NPC156728
Ingredient ID: NPC154
Ingredient ID: NPC152451
Ingredient ID: NPC151403
Ingredient ID: NPC150950
Ingredient ID: NPC150926
Ingredient ID: NPC147983
Ingredient ID: NPC147390
Ingredient ID: NPC145914
Ingredient ID: NPC140697
Ingredient ID: NPC136508
Ingredient ID: NPC135182
Ingredient ID: NPC134758
Ingredient ID: NPC134357
Ingredient ID: NPC134319
Ingredient ID: NPC124313
Ingredient ID: NPC124252
Ingredient ID: NPC119579
Ingredient ID: NPC117717
Ingredient ID: NPC117433
Ingredient ID: NPC115641
Ingredient ID: NPC114124
Ingredient ID: NPC11332
Ingredient ID: NPC112890
Ingredient ID: NPC109701
Ingredient ID: NPC105638
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Therapeutic Target | Membrane receptor | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
| Therapeutic Target | Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Therapeutic Target | Protein Kinase | CDK2 | Cyclin-dependent kinase 2 | P24941 | CHEMBL301 |
| Therapeutic Target | Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD2 | Dopamine D2 receptor | P14416 | CHEMBL217 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HTR5A | Serotonin 5a (5-HT5a) receptor | P47898 | CHEMBL3426 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 1310 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Pyridoxine (NPC269919);Folic Acid (NPC147983);Beta Carotene (NPC17810) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03090048,NCT03522922
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKA
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute leukaemias of ambiguous lineageDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A61 |
NCT02419755
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKA,TOP2A,CREBBP
NCT00329498,NCT00184054,NCT01842139,NCT03059615,NCT03860844 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
NCT04404387 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
