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Collective Molecular Activities of the Plant: Afrocarpus Gracilior


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO28741
Plant Latin Name: Afrocarpus Gracilior
Taxonomy Genus: Afrocarpus
Taxonomy Family: Podocarpaceae

Plant External Links:

NCBI TaxonomyDB: 165205
Plant-of-the-World-Online: n.a.

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

34 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


15 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

18 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC77249

Ingredient ID: NPC65786

Ingredient ID: NPC43094

Ingredient ID: NPC311830

Ingredient ID: NPC299856

Ingredient ID: NPC286667

Ingredient ID: NPC278680

Ingredient ID: NPC270675

Ingredient ID: NPC265442

Ingredient ID: NPC252918

Ingredient ID: NPC247586

Ingredient ID: NPC245853

Ingredient ID: NPC243083

Ingredient ID: NPC231772

Ingredient ID: NPC230789

Ingredient ID: NPC214585

Ingredient ID: NPC214168

Ingredient ID: NPC210003

Ingredient ID: NPC201806

Ingredient ID: NPC195685

Ingredient ID: NPC194873

Ingredient ID: NPC180407

Ingredient ID: NPC157699

Ingredient ID: NPC156869

Ingredient ID: NPC156851

Ingredient ID: NPC146713

Ingredient ID: NPC142319

Ingredient ID: NPC140154

Ingredient ID: NPC137062

Ingredient ID: NPC130683

Ingredient ID: NPC123965

Ingredient ID: NPC115289

Ingredient ID: NPC113101

Ingredient ID: NPC100052

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Therapeutic Target Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Therapeutic Target Oxidoreductase MAOB Monoamine oxidase B P27338 CHEMBL2039
Therapeutic Target Protein Kinase CDK8 Cell division protein kinase 8 P49336 CHEMBL5719
Therapeutic Target Transcription factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level20
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT00218946 Nasogastric Tube in Premature Babies - Pain and Treatment premature birth Sucrose (NPC130683) NP level
NCT01238471 Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study retinopathy of prematurity Sucrose (NPC130683) NP level
NCT02086864 A Placebo Controlled Study of Homeopathic Treatment of Children and Youth With ADHD attention deficit hyperactivity disorder Sucrose (NPC130683) NP level
NCT00949104 Role of Oral Sucrose in Reducing the Pain to Orogastric Tube Insertion in Preterm Neonates pain Sucrose (NPC130683) NP level
NCT00482560 Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening pain Sucrose (NPC130683) NP level
NCT03272594 The Influence of Breastfeeding on Cortical Activity During Procedures pain Sucrose (NPC130683) NP level
NCT03745963 The Influence of Skin-to-skin Contact on Cortical Activity During Painful Procedures on Preterm Infants in the NICU pain Sucrose (NPC130683) NP level
NCT03718507 Study on the Effects of Different Premedication for LISA on Stress and Cerebral Tissue Oxygenation in Preterm Infants acute respiratory distress syndrome Sucrose (NPC130683) NP level
NCT01503060 Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain pain Sucrose (NPC130683) NP level
NCT02174705 Rotavirus vs. Sucrose for Vaccine Injection Pain pain Sucrose (NPC130683) NP level
NCT02990364 Combination Analgesia for Neonatal Circumcision pain Sucrose (NPC130683) NP level
NCT04855266 Iron Sucrose in Patients With Iron Deficiency and POTS orthostatic hypotension Sucrose (NPC130683) NP level
NCT01561547 Trial of Repeated Analgesia With Kangaroo Care pain Sucrose (NPC130683) NP level
NCT01190995 Role of Repeated Painful Procedures in Preterm Neonates on Short Term Neurobehavioural Outcome pain Sucrose (NPC130683) NP level
NCT01201954 Pain Relief of Newborn Preterm Infants During Endotracheal Suctioning pain Sucrose (NPC130683) NP level
NCT00787059 AC6 Gene Transfer for CHF congestive heart failure Sucrose (NPC130683) NP level
NCT00519207 Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture pain Sucrose (NPC130683) NP level
NCT00717652 Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma freckles Arbutin (NPC142319) NP level
NCT03082001 Sucrose to Reduce Pain During Initiation of Venipuncture in Extremely Low Birth Weight Babies pain Sucrose (NPC130683) NP level
NCT02059785 Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke Ischemic stroke Pinocembrin (NPC243083) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 HIF1A,MAOB,CYP2C19,CYP1B1
Parkinsonism
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00
 MAOA,MAOB
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 MAOB,MAOA
Pulmonary hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BB01
 MAOB,HIF1A
Acquired hypomelanotic disorder
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED63
 MAOB,MAOA
Depression
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A70-6A7Z
 MAOA,MAOB
Skin tag/polyp
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EK71
 MAOB,MAOA
General pain disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E43
 MAOA,MAOB
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 MAOA,MAOB
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 MAOB,CDK8
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 CYP19A1,CYP19A1
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 CYP1A1,CYP2C19
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 HIF1A,CYP19A1
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 CYP1B1,CYP19A1
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 CYP1A1,CYP1A2
Pain, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG3Z
 NCT01201954,NCT03272594,NCT00949104,NCT00482560,NCT01190995,NCT00519207,NCT02990364,NCT03082001,NCT01503060,NCT02174705,NCT03745963,NCT01561547
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 CYP19A1
Muscular dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C70
 MAOB
Malaria
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F40-1F45
 MAOB
Cushing syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A70
 CYP19A1
Brain cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00
 HIF1A
Mood disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A60-6E23
 MAOA
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 HIF1A
Myelodysplastic syndrome
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A37
 CDK8
Neuropathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C0Z
 CYP19A1
Skin cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30-2C37
 MAOB
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 HIF1A
Nausea/vomiting
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MD90
 MAOB
Endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10
 CYP19A1
Adrenomedullary hyperfunction
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A75
 HIF1A
Migraine
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A80
 MAOB
Substance abuse
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40
 MAOA
Oesophagitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA24
 CYP19A1
Dementia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D80-6D8Z
 MAOB
Primary psychotic disorder manifestation
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A25
 MAOB
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 CDK8
Freckles
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED61.0
 NCT00717652
Retinopathy of prematurity
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B71.3
 NCT01238471
Congestive heart failure
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD10
 NCT00787059
Orthostatic hypotension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA21
 NCT04855266
Preterm newborn, unspecified
Disease Category: 19.Certain conditions originating in the perinatal period
Disease ICD-11 Code: KA21.4Z
 NCT00218946
Acute respiratory distress syndrome
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB00
 NCT03718507
Attention deficit hyperactivity disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A05
 NCT02086864
Cerebral ischaemic stroke
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B11
 NCT02059785
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 CYP19A1
Coeliac disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA95
 CYP1A1
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 CYP1A2
Dengue fever, unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D2Z
 MAOA
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 HIF1A
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 CYP19A1
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 CYP19A1
Myotonic dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C71.0
 CYP1A1
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 CYP19A1
West Nile virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D46
 CYP19A1
Other specified malignant neoplasms ofcolon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 CYP1A1
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 CYP1A2
Chronic rhinosinusitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0A
 CYP1A1
Systemic lupus erythematosus
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A40.0
 CYP1A1
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 CYP1B1
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 CYP1A1
Polycystic ovary syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A80.1
 CDK8
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 CYP1B1
Heart failure, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD1Z
 CYP1B1
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 HIF1A
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 CYP1B1
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 CYP19A1

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
Prof. Chen Yu Zong
chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
dyhou22@m.fudan.edu.cn
Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
yhfeng22@m.fudan.edu.cn

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