Collective Molecular Activities of the Plant: Aster Tataricus
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antibacterial; Antifungal; Antitussive; Cancer; Expectorant
South Africa; Mongolia; United States; Germany; Japan; China; South Korea; Russia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
140 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
87 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
58 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99886
Ingredient ID: NPC99480
Ingredient ID: NPC97490
Ingredient ID: NPC96767
Ingredient ID: NPC95676
Ingredient ID: NPC94304
Ingredient ID: NPC94218
Ingredient ID: NPC94045
Ingredient ID: NPC93213
Ingredient ID: NPC93033
Ingredient ID: NPC92774
Ingredient ID: NPC90787
Ingredient ID: NPC85813
Ingredient ID: NPC85327
Ingredient ID: NPC83578
Ingredient ID: NPC82648
Ingredient ID: NPC82363
Ingredient ID: NPC82046
Ingredient ID: NPC79527
Ingredient ID: NPC78540
Ingredient ID: NPC76145
Ingredient ID: NPC71506
Ingredient ID: NPC67449
Ingredient ID: NPC63941
Ingredient ID: NPC63540
Ingredient ID: NPC62765
Ingredient ID: NPC62086
Ingredient ID: NPC5708
Ingredient ID: NPC52230
Ingredient ID: NPC51748
Ingredient ID: NPC51308
Ingredient ID: NPC4827
Ingredient ID: NPC480424
Ingredient ID: NPC480423
Ingredient ID: NPC480422
Ingredient ID: NPC480421
Ingredient ID: NPC480420
Ingredient ID: NPC480419
Ingredient ID: NPC480418
Ingredient ID: NPC480417
Ingredient ID: NPC42403
Ingredient ID: NPC4125
Ingredient ID: NPC39400
Ingredient ID: NPC3922
Ingredient ID: NPC3649
Ingredient ID: NPC331613
Ingredient ID: NPC320001
Ingredient ID: NPC3190
Ingredient ID: NPC312929
Ingredient ID: NPC312560
Ingredient ID: NPC312391
Ingredient ID: NPC309355
Ingredient ID: NPC307063
Ingredient ID: NPC306616
Ingredient ID: NPC302857
Ingredient ID: NPC299529
Ingredient ID: NPC297517
Ingredient ID: NPC290791
Ingredient ID: NPC282923
Ingredient ID: NPC281994
Ingredient ID: NPC279026
Ingredient ID: NPC278068
Ingredient ID: NPC270074
Ingredient ID: NPC269806
Ingredient ID: NPC268862
Ingredient ID: NPC268292
Ingredient ID: NPC266021
Ingredient ID: NPC266020
Ingredient ID: NPC26583
Ingredient ID: NPC265513
Ingredient ID: NPC261831
Ingredient ID: NPC26065
Ingredient ID: NPC259134
Ingredient ID: NPC258723
Ingredient ID: NPC257522
Ingredient ID: NPC254847
Ingredient ID: NPC251437
Ingredient ID: NPC249018
Ingredient ID: NPC243601
Ingredient ID: NPC233393
Ingredient ID: NPC229419
Ingredient ID: NPC229403
Ingredient ID: NPC225406
Ingredient ID: NPC225284
Ingredient ID: NPC224389
Ingredient ID: NPC223417
Ingredient ID: NPC22084
Ingredient ID: NPC219961
Ingredient ID: NPC219573
Ingredient ID: NPC216630
Ingredient ID: NPC216330
Ingredient ID: NPC215702
Ingredient ID: NPC213322
Ingredient ID: NPC210040
Ingredient ID: NPC20892
Ingredient ID: NPC208382
Ingredient ID: NPC20791
Ingredient ID: NPC207869
Ingredient ID: NPC206380
Ingredient ID: NPC206095
Ingredient ID: NPC202691
Ingredient ID: NPC197378
Ingredient ID: NPC194383
Ingredient ID: NPC189698
Ingredient ID: NPC188238
Ingredient ID: NPC188168
Ingredient ID: NPC184515
Ingredient ID: NPC184049
Ingredient ID: NPC181582
Ingredient ID: NPC180612
Ingredient ID: NPC178859
Ingredient ID: NPC177112
Ingredient ID: NPC175722
Ingredient ID: NPC17458
Ingredient ID: NPC173658
Ingredient ID: NPC170070
Ingredient ID: NPC166894
Ingredient ID: NPC163424
Ingredient ID: NPC162422
Ingredient ID: NPC157923
Ingredient ID: NPC15292
Ingredient ID: NPC149570
Ingredient ID: NPC149203
Ingredient ID: NPC148677
Ingredient ID: NPC143639
Ingredient ID: NPC143252
Ingredient ID: NPC142871
Ingredient ID: NPC142703
Ingredient ID: NPC142187
Ingredient ID: NPC13998
Ingredient ID: NPC138347
Ingredient ID: NPC127447
Ingredient ID: NPC125962
Ingredient ID: NPC122369
Ingredient ID: NPC121270
Ingredient ID: NPC116775
Ingredient ID: NPC114239
Ingredient ID: NPC105707
Ingredient ID: NPC105380
Ingredient ID: NPC100178
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 38 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,DPP4,PPARA,NR3C1,AKR1B1,FFAR1,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,AXL,TP53,FLT3,PIM1,SRC
|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
NR3C1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP2C9,CDK1,CA7,CA12,TSHR,AKR1C3,XDH,AKR1B10,NPSR1,AURKB,CBR1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP2C9,PGR,CISD1,RECQL,FABP3,ABCG2,OR51E2,LMNA,DPP4,HSD17B2,ALOX5,CYP1B1,APP,ALOX15,CA7,AXL,AKR1C3,NAPRT,XDH,PIM1,FFAR4,POLB,MET,AKR1B10,NPSR1,AURKB,CYP2C19,CBR1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5,ALOX15,NOX4
NCT01912820 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
