Collective Molecular Activities of the Plant: Cuscuta Australis
Country/Region:
ChinaTraditional Medicine System:
TCMTurkey; Madagascar; Italy; Bangladesh; Sudan; Hungary; France; Ethiopia; Somalia; Nigeria; Cameroon; Cote d'Ivoire; Turkmenistan; Ghana; Australia; Iran; Algeria; Zambia; China; Kazakhstan; Sierra Leone; Ukraine; Liberia; Tanzania; Indonesia; Morocco; Vietnam; Japan; Switzerland; Russia; Bulgaria; Portugal; South Africa; Tunisia; India; Uzbekistan; Uganda; Greece; Kenya; Taiwan; Tajikistan; Botswana
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
102 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
64 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
41 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95676
Ingredient ID: NPC94304
Ingredient ID: NPC94218
Ingredient ID: NPC94045
Ingredient ID: NPC93033
Ingredient ID: NPC90787
Ingredient ID: NPC87238
Ingredient ID: NPC85813
Ingredient ID: NPC85327
Ingredient ID: NPC82648
Ingredient ID: NPC82363
Ingredient ID: NPC79527
Ingredient ID: NPC78540
Ingredient ID: NPC78263
Ingredient ID: NPC76145
Ingredient ID: NPC62086
Ingredient ID: NPC5708
Ingredient ID: NPC50898
Ingredient ID: NPC4827
Ingredient ID: NPC4125
Ingredient ID: NPC3922
Ingredient ID: NPC3649
Ingredient ID: NPC3190
Ingredient ID: NPC312391
Ingredient ID: NPC309355
Ingredient ID: NPC308404
Ingredient ID: NPC306616
Ingredient ID: NPC302857
Ingredient ID: NPC299529
Ingredient ID: NPC295745
Ingredient ID: NPC281994
Ingredient ID: NPC281457
Ingredient ID: NPC281131
Ingredient ID: NPC278068
Ingredient ID: NPC270074
Ingredient ID: NPC269806
Ingredient ID: NPC268862
Ingredient ID: NPC26583
Ingredient ID: NPC265513
Ingredient ID: NPC26510
Ingredient ID: NPC261831
Ingredient ID: NPC258723
Ingredient ID: NPC257522
Ingredient ID: NPC257272
Ingredient ID: NPC249018
Ingredient ID: NPC243601
Ingredient ID: NPC234153
Ingredient ID: NPC229403
Ingredient ID: NPC225434
Ingredient ID: NPC225406
Ingredient ID: NPC225284
Ingredient ID: NPC223417
Ingredient ID: NPC219573
Ingredient ID: NPC216330
Ingredient ID: NPC215702
Ingredient ID: NPC213322
Ingredient ID: NPC210040
Ingredient ID: NPC20892
Ingredient ID: NPC20791
Ingredient ID: NPC207869
Ingredient ID: NPC206380
Ingredient ID: NPC206095
Ingredient ID: NPC202691
Ingredient ID: NPC197378
Ingredient ID: NPC196745
Ingredient ID: NPC194383
Ingredient ID: NPC194081
Ingredient ID: NPC186047
Ingredient ID: NPC181582
Ingredient ID: NPC180612
Ingredient ID: NPC178859
Ingredient ID: NPC176740
Ingredient ID: NPC17458
Ingredient ID: NPC173658
Ingredient ID: NPC171928
Ingredient ID: NPC170070
Ingredient ID: NPC167976
Ingredient ID: NPC166894
Ingredient ID: NPC163424
Ingredient ID: NPC159611
Ingredient ID: NPC157923
Ingredient ID: NPC15292
Ingredient ID: NPC149570
Ingredient ID: NPC149203
Ingredient ID: NPC148677
Ingredient ID: NPC142871
Ingredient ID: NPC142703
Ingredient ID: NPC135391
Ingredient ID: NPC133671
Ingredient ID: NPC127447
Ingredient ID: NPC125962
Ingredient ID: NPC125062
Ingredient ID: NPC124359
Ingredient ID: NPC121270
Ingredient ID: NPC117529
Ingredient ID: NPC116775
Ingredient ID: NPC114239
Ingredient ID: NPC110942
Ingredient ID: NPC1075
Ingredient ID: NPC105380
Ingredient ID: NPC100223
Ingredient ID: NPC100178
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 39 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,KDR,DPP4,AKR1B1,FFAR1,PPARA
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,TP53,PIM1,SRC,FLT3,AXL
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
THPO,NPSR1,CYP2C9,CA7,TTR,AKR1C3,CA12,CBR1,TSHR,AURKB,ACHE,CDK1,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX5,CYP1B1,NPSR1,CYP2C9,CA7,FFAR4,TTR,ALOX15,AKR1C3,FABP3,APP,ABCG2,PIM1,RECQL,CBR1,DPP4,POLB,CA2,CISD1,LMNA,HSD17B2,AXL,CYP2C19,AURKB,MET,ACHE,XDH
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,NOX4,TTR,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NPSR1,NOX4,AURKB,CYP19A1,MET,CDK1,ALOX15
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT05422885,NCT04946383
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KDR,ACHE,ESR2,FLT3,APP,MET
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
