• Home
  • About
  • Browse
  • Help
  • Download

Collective Molecular Activities of the Plant: Tetragonia Tetragonioides


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO28580
Plant Latin Name: Tetragonia Tetragonioides
Taxonomy Genus: Tetragonia
Taxonomy Family: Aizoaceae

Plant External Links:

NCBI TaxonomyDB: 45318
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:
New Zealand; India

Traditional Medicine System:

Geographical Distribution

New Zealand; India

Geographical Distribution
+
−
See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

38 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


15 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

14 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.






Ingredient Structrual Cards


Ingredient ID: NPC99760

Ingredient ID: NPC94547

Ingredient ID: NPC71874

Ingredient ID: NPC48971

Ingredient ID: NPC42459

Ingredient ID: NPC37240

Ingredient ID: NPC311158

Ingredient ID: NPC308029

Ingredient ID: NPC294902

Ingredient ID: NPC285283

Ingredient ID: NPC271300

Ingredient ID: NPC253336

Ingredient ID: NPC250311

Ingredient ID: NPC247626

Ingredient ID: NPC242129

Ingredient ID: NPC241911

Ingredient ID: NPC23637

Ingredient ID: NPC225434

Ingredient ID: NPC210506

Ingredient ID: NPC209751

Ingredient ID: NPC20791

Ingredient ID: NPC192466

Ingredient ID: NPC185937

Ingredient ID: NPC179950

Ingredient ID: NPC176740

Ingredient ID: NPC176471

Ingredient ID: NPC173407

Ingredient ID: NPC163204

Ingredient ID: NPC162659

Ingredient ID: NPC162289

Ingredient ID: NPC158088

Ingredient ID: NPC156073

Ingredient ID: NPC148270

Ingredient ID: NPC142415

Ingredient ID: NPC133671

Ingredient ID: NPC125244

Ingredient ID: NPC102323

Ingredient ID: NPC101018

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target TypeProtein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
Therapeutic Target Enzyme CES1 Acyl coenzyme A:cholesterol acyltransferase P23141 CHEMBL2265
Therapeutic Target Enzyme ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Therapeutic Target Enzyme NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Therapeutic Target Enzyme POLB DNA polymerase beta P06746 CHEMBL2392
Therapeutic Target Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Therapeutic Target Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Therapeutic Target Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Therapeutic Target Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Therapeutic Target Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Therapeutic Target Metallo protease MMP1 Matrix metalloproteinase-1 P03956 CHEMBL332
Showing 1 to 10 of 27 entries
Previous123Next
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level37
Clinical trial details
NCT IDTitleConditionForm in clinical useAssociated by plant or compound
NCT00455416 Dietary Intervention in Follicular Lymphoma follicular lymphoma Quercetin (NPC20791) NP level
NCT01348204 Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators cystic fibrosis Quercetin (NPC20791) NP level
NCT01375101 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus oral lichen planus Quercetin (NPC20791) NP level
NCT01438320 Q-Trial in Patients With Hepatitis C chronic hepatitis C virus infection Quercetin (NPC20791) NP level
NCT01705652 Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients prostate cancer Rutin (NPC176740) NP level
NCT01708278 Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) chronic obstructive pulmonary disease Quercetin (NPC20791) NP level
NCT01720147 Quercetin in Children With Fanconi Anemia; a Pilot Study Fanconi anemia Quercetin (NPC20791) NP level
NCT01839344 Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. type 2 diabetes mellitus Quercetin (NPC20791) NP level
NCT01912820 Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery prostate adenocarcinoma Quercetin (NPC20791) NP level
NCT02136342 Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer cancer Chlorogenic Acid (NPC302857) NP level
Showing 1 to 10 of 37 entries
Previous1234Next

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Acne vulgaris
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED80
 MMP2
Acute diabete complication
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A2Y
 AURKB,KDR,PTPN1,AKR1B1
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 FLT3,SRC,AXL,TP53,PTPRC,AURKB,PIM1,NFKB1,KDM1A
Acute respiratory distress syndrome
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB00
 F3
Acute/subacute hepatic failure
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB91
 NFKB1
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 CA12,CDK1,MMP9,ACHE,AKR1B10,NPSR1,AURKB,MMP1,CA7,XDH
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 RECQL,MMP1,ABCG2,MMP2,PTPN1,ALOX5,CYP1B1,ALOX15,CA7,AXL,CA2,XDH,CDC25B,PIM1,PTPRC,POLB,MET,ACHE,AKR1B10,NPSR1,AURKB,CES1
Adenocarcinoma of prostate
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82.0
 ALOX15,NOX4
 NCT01912820
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 CDK1,ALOX15,NOX4,MET,MMP9,NPSR1,AURKB,MMP1,CYP19A1,CDC25B
Ageing associated decline in intrinsic capacity
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG2A
 NCT04946383,NCT05422885
Showing 1 to 10 of 227 entries
Previous12345…23Next

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

CMAUP

Home

About

Browse

Help

Useful links

BIDD home

NPASS database

TCM-ID database

TTD database

Contact

826 Zhangheng Road, Pudong New District, Shanghai, China

Principle Investigator:
Prof. Chen Yu Zong
chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
dyhou22@m.fudan.edu.cn
Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
yhfeng22@m.fudan.edu.cn

© 2023 Copyright: Bioinformatics & Drug Design group