CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Achillea Clypeolata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO28509
Plant Latin Name: Achillea Clypeolata
Taxonomy Genus: Achillea
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 282728
Plant-of-the-World-Online: n.a.

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

117 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

22 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

47 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC98661

Ingredient ID: NPC92143

Ingredient ID: NPC91757

Ingredient ID: NPC90096

Ingredient ID: NPC88971

Ingredient ID: NPC88278

Ingredient ID: NPC87828

Ingredient ID: NPC87132

Ingredient ID: NPC87015

Ingredient ID: NPC86412

Ingredient ID: NPC86093

Ingredient ID: NPC84842

Ingredient ID: NPC82705

Ingredient ID: NPC8039

Ingredient ID: NPC73318

Ingredient ID: NPC71074

Ingredient ID: NPC708

Ingredient ID: NPC67446

Ingredient ID: NPC65823

Ingredient ID: NPC62086

Ingredient ID: NPC58575

Ingredient ID: NPC56035

Ingredient ID: NPC52021

Ingredient ID: NPC51700

Ingredient ID: NPC41961

Ingredient ID: NPC41518

Ingredient ID: NPC38203

Ingredient ID: NPC37250

Ingredient ID: NPC34338

Ingredient ID: NPC312800

Ingredient ID: NPC312553

Ingredient ID: NPC307282

Ingredient ID: NPC305464

Ingredient ID: NPC302857

Ingredient ID: NPC300351

Ingredient ID: NPC299912

Ingredient ID: NPC29641

Ingredient ID: NPC296355

Ingredient ID: NPC294906

Ingredient ID: NPC290365

Ingredient ID: NPC288956

Ingredient ID: NPC288932

Ingredient ID: NPC28811

Ingredient ID: NPC284948

Ingredient ID: NPC281254

Ingredient ID: NPC278032

Ingredient ID: NPC276610

Ingredient ID: NPC269349

Ingredient ID: NPC263548

Ingredient ID: NPC26144

Ingredient ID: NPC258892

Ingredient ID: NPC24983

Ingredient ID: NPC248222

Ingredient ID: NPC247276

Ingredient ID: NPC244398

Ingredient ID: NPC243728

Ingredient ID: NPC238811

Ingredient ID: NPC235260

Ingredient ID: NPC234617

Ingredient ID: NPC230896

Ingredient ID: NPC228633

Ingredient ID: NPC227806

Ingredient ID: NPC226141

Ingredient ID: NPC225710

Ingredient ID: NPC224389

Ingredient ID: NPC223602

Ingredient ID: NPC221435

Ingredient ID: NPC216053

Ingredient ID: NPC215624

Ingredient ID: NPC213749

Ingredient ID: NPC213572

Ingredient ID: NPC20924

Ingredient ID: NPC20791

Ingredient ID: NPC206095

Ingredient ID: NPC201018

Ingredient ID: NPC194842

Ingredient ID: NPC189224

Ingredient ID: NPC188591

Ingredient ID: NPC184937

Ingredient ID: NPC18074

Ingredient ID: NPC179950

Ingredient ID: NPC179114

Ingredient ID: NPC178370

Ingredient ID: NPC178134

Ingredient ID: NPC170380

Ingredient ID: NPC166625

Ingredient ID: NPC163339

Ingredient ID: NPC162742

Ingredient ID: NPC159036

Ingredient ID: NPC158371

Ingredient ID: NPC158059

Ingredient ID: NPC145667

Ingredient ID: NPC143889

Ingredient ID: NPC141855

Ingredient ID: NPC14157

Ingredient ID: NPC13818

Ingredient ID: NPC138113

Ingredient ID: NPC134835

Ingredient ID: NPC133671

Ingredient ID: NPC133404

Ingredient ID: NPC133166

Ingredient ID: NPC130278

Ingredient ID: NPC130216

Ingredient ID: NPC129088

Ingredient ID: NPC12725

Ingredient ID: NPC121788

Ingredient ID: NPC121648

Ingredient ID: NPC120625

Ingredient ID: NPC120123

Ingredient ID: NPC116775

Ingredient ID: NPC11666

Ingredient ID: NPC114239

Ingredient ID: NPC112366

Ingredient ID: NPC109813

Ingredient ID: NPC109731

Ingredient ID: NPC108709

Ingredient ID: NPC101744

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Drug Transporter	SLC superfamily of solute carriers	SLC22A6	Solute carrier family 22 member 6	Q4U2R8	CHEMBL1641347
Therapeutic Target	Enzyme	POLB	DNA polymerase beta	P06746	CHEMBL2392
Therapeutic Target	Enzyme	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Therapeutic Target	Enzyme	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Therapeutic Target	Enzyme	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Therapeutic Target	Enzyme	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Therapeutic Target	Enzyme	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619

Showing 1 to 10 of 51 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	95

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00061997	Inositol in Preventing Lung Cancer in Patients With Bronchial Epithelial Dysplasia Who Are Current or Former Smokers	lung cancer	Inositol (NPC88278)	NP level
NCT00113854	Mannitol as Adjunct Therapy for Childhood Cerebral Malaria	malaria	Mannitol (NPC86412)	NP level
NCT00117208	Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis	cystic fibrosis	Mannitol (NPC86412)	NP level
NCT00189007	Antenatal Allopurinol During Fetal Hypoxia	fetal hypoxia	Mannitol (NPC86412)	NP level
NCT00251056	Mannitol Dose Response Study in Cystic Fibrosis	cystic fibrosis	Mannitol (NPC86412)	NP level
NCT00277537	Safety and Efficacy of Bronchitol in Bronchiectasis	Bronchiectasis	Mannitol (NPC86412)	NP level
NCT00303849	Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors	anaplastic oligodendroglioma	Mannitol (NPC86412)	NP level
NCT00359697	Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure	intracranial hypertension	Mannitol (NPC86412)	NP level
NCT00446667	A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD	chronic obstructive pulmonary disease	Mannitol (NPC86412)	NP level
NCT00446680	Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study	cystic fibrosis	Mannitol (NPC86412)	NP level

Showing 1 to 10 of 95 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acquired hypermelanosis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED60	TYR
Acquired hypomelanotic disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED63	TYR
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	KDR,AKR1B1,DPP4,INSR,HSD11B1,AURKB
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	PIM1,KDM1A,SRC,AXL,FLT3,TP53,RELA,AURKB
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	RELA
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	GPR35,NPSR1,AURKB,CA12,CYP2C9,AKR1B10,CDK1,XDH,CA7
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	FUT7,ALOX5,CYP1B1,NPSR1,CYP2C9,CNR2,TEK,CA7,HSD11B1,ALOX15,CES1,APP,ABCG2,PIM1,RECQL,DPP4,POLB,CA2,CISD1,LMNA,HSD17B2,AXL,AURKB,NUAK1,MET,AKR1B10,XDH
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	NOX4,ALOX15 NCT01912820
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	CDK1,NPSR1,AURKB,NOX4,CYP19A1,MET,ALOX15
Ageing associated decline in intrinsic capacity Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG2A	NCT05422885,NCT04946383

Showing 1 to 10 of 259 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Achillea Clypeolata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

117 All known Ingredients in Total

22 Ingredients with Acceptable Bioavailablity

47 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acquired hypermelanosis

Acquired hypomelanotic disorder

Acute diabete complication

Acute myeloid leukaemia

Acute/subacute hepatic failure

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of prostate

Adenocarcinoma of stomach

Ageing associated decline in intrinsic capacity

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities