Collective Molecular Activities of the Plant: Sabia Japonica
Plant ID: NPO28422
Plant Latin Name: Sabia Japonica
Taxonomy Genus: Sabia
Taxonomy Family: Sabiaceae
Plant External Links:
NCBI TaxonomyDB:
400538
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
42 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
23 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC83970
Ingredient ID: NPC81010
Ingredient ID: NPC806
Ingredient ID: NPC73288
Ingredient ID: NPC70744
Ingredient ID: NPC58279
Ingredient ID: NPC33667
Ingredient ID: NPC310816
Ingredient ID: NPC308599
Ingredient ID: NPC306975
Ingredient ID: NPC300326
Ingredient ID: NPC300017
Ingredient ID: NPC297180
Ingredient ID: NPC294941
Ingredient ID: NPC293356
Ingredient ID: NPC292129
Ingredient ID: NPC289774
Ingredient ID: NPC266113
Ingredient ID: NPC265148
Ingredient ID: NPC257653
Ingredient ID: NPC251029
Ingredient ID: NPC250019
Ingredient ID: NPC248996
Ingredient ID: NPC234853
Ingredient ID: NPC230519
Ingredient ID: NPC230301
Ingredient ID: NPC205084
Ingredient ID: NPC204848
Ingredient ID: NPC196690
Ingredient ID: NPC183388
Ingredient ID: NPC165114
Ingredient ID: NPC159464
Ingredient ID: NPC156018
Ingredient ID: NPC150148
Ingredient ID: NPC149602
Ingredient ID: NPC147597
Ingredient ID: NPC144939
Ingredient ID: NPC140734
Ingredient ID: NPC137537
Ingredient ID: NPC130700
Ingredient ID: NPC12278
Ingredient ID: NPC111089
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | MIF | Macrophage migration inhibitory factor | P14174 | CHEMBL2085 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Therapeutic Target | Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,TRPA1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA2,F2,TRPA1,SNCA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
