Collective Molecular Activities of the Plant: Acanthophyllum Elatius
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PLANiTS DNA barcode
Taxonomic Information
Plant ID: NPO28387
Plant Latin Name: Acanthophyllum Elatius
Taxonomy Genus: Acanthophyllum
Taxonomy Family: Caryophyllaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
150229-1
Used in Medicines
Unknown.
Geographical Distribution
Tajikistan; Afghanistan; Iran; Turkmenistan
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
15 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
6 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
12 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC294548
Ingredient ID: NPC286245
Ingredient ID: NPC261831
Ingredient ID: NPC256849
Ingredient ID: NPC255837
Ingredient ID: NPC250436
Ingredient ID: NPC244690
Ingredient ID: NPC219876
Ingredient ID: NPC176740
Ingredient ID: NPC173637
Ingredient ID: NPC167983
Ingredient ID: NPC160512
Ingredient ID: NPC126029
Ingredient ID: NPC119133
Ingredient ID: NPC102281
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Therapeutic Target | DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Therapeutic Target | Other nuclear protein | RAD52 | DNA repair protein RAD52 homolog | P43351 | CHEMBL2362978 |
| Therapeutic Target | Oxidoreductase | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
| Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Threonine protease | PSMB5 | Proteasome Macropain subunit MB1 | P28074 | CHEMBL4662 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 142 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01744587 | Epstein-Barr Virus Reactivation and the Effect of EGCG on Virus Reactivation in Remission Patients | nasopharyngeal neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02627898 | Effect of Green Tea Extract on Arterial Stiffness in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT01190735 | Caffeine for Motor Manifestations of Parkinson's Disease | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT03928847 | Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis. | idiopathic pulmonary fibrosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01699711 | Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool | Down syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
| NCT02323698 | Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury | Spinal cord injury | Caffeine (NPC256849) | NP level |
| NCT02582996 | Cefalium® Compared to Tylenol® in the Treatment of Migraine Attacks | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
| NCT03321734 | Intermittent Hypoxia and Caffeine in Infants Born Preterm | hypoxia | Caffeine (NPC256849) | NP level |
| NCT00432887 | Experimental Studies of the Effects of Caffeine on Glucose Regulation | type 2 diabetes mellitus | Caffeine (NPC256849) | NP level |
| NCT01394796 | Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. | Down syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00091325 | Green Tea Extract (Polyphenon E) in Preventing Cancer in Healthy Participants | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00388128 | Caffeine and Intermittent Claudication | intermittent vascular claudication | Caffeine (NPC256849) | NP level |
| NCT05364008 | FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate | uterine fibroid | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00302289 | B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients | obesity | Caffeine (NPC256849) | NP level |
| NCT01525628 | Drug Drug Interaction Study Between BI 201335 and BI 207127 in Chronic Hepatitis C Infected Patients | chronic hepatitis C virus infection | Caffeine (NPC256849) | NP level |
| NCT00707252 | Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer | non-small cell lung carcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02863575 | A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine | pain | Caffeine (NPC256849) | NP level |
| NCT01426971 | Ibuprofen Versus Ibuprofen Plus Caffeine in the Treatment of Migraine. | pain | Caffeine (NPC256849) | NP level |
| NCT05485805 | A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo | toothache | Caffeine (NPC256849) | NP level |
| NCT02397382 | Pharmacokinetic Study to Evaluate the Effect of a Single Dose of Guselkumab (CNTO 1959) on CYP 450 Enzyme Activities After Subcutaneous Administration in Participants With Psoriasis | psoriasis | Caffeine (NPC256849) | NP level |
| NCT01183767 | Sunphenon Epigallocatechin-Gallate (EGCg) in Duchenne Muscular Dystrophy | Duchenne muscular dystrophy | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01462318 | An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis | relapsing-remitting multiple sclerosis | Caffeine (NPC256849) | NP level |
| NCT01999829 | Prevention of Atrial Fibrillation Following Valvular Replacement With Cardiopulmonary Bypass: a Prospective, Randomized Clinical Study Comparing Oral Caffeine With Placebo | atrial fibrillation | Caffeine (NPC256849) | NP level |
| NCT00223691 | Treatment of Orthostatic Hypotension in Autonomic Failure | orthostatic hypotension | Caffeine (NPC256849) | NP level |
| NCT02311088 | Trial of Caffeine to Alleviate Dyspnea Related to Ticagrelor | Dyspnea | Caffeine (NPC256849) | NP level |
| NCT01517399 | Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects | neoplasm | Caffeine (NPC256849) | NP level |
| NCT00262743 | Green Tea Extract in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia | leukemia | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02731495 | Effect of Epigallocatechin -3-gallate Supplementation in Traumatic Brain Injury Patients | brain injury | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00459420 | Caffeine for Excessive Daytime Somnolence in Parkinson's Disease | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT03556592 | Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4 | atopic eczema | Caffeine (NPC256849) | NP level |
| NCT03768492 | Study of the Safety and Efficacy of a Caffeine-based Antifibrosis Cream in Patients With Breast Cancer Undergoing Radiation Therapy | breast carcinoma | Caffeine (NPC256849) | NP level |
| NCT00363805 | Green Tea or Polyphenon E in Preventing Lung Cancer in Former Smokers With Chronic Obstructive Pulmonary Disease | lung cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00596011 | Study of Polyphenon E in Men With High-grade Prostatic Intraepithelial Neoplasia | benign prostatic hyperplasia | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00930306 | AZD2066 Cocktail Study | Chronic pain | Caffeine (NPC256849) | NP level |
| NCT04570085 | Effect of CAFfeine on Cognition in Alzheimer's Disease | Alzheimer disease | Caffeine (NPC256849) | NP level |
| NCT01755702 | Paracetamol With Caffeine to Treat Episodic Tension Type Headache | Tension-type headache | Caffeine (NPC256849) | NP level |
| NCT04643249 | Drug-drug Interaction Study of KL1333 in Healthy Subjects | mitochondrial disease | Caffeine (NPC256849) | NP level |
| NCT04132336 | Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed | pain | Caffeine (NPC256849) | NP level |
| NCT01340599 | Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer Undergoing Surgery | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04553666 | Reducing Frailty for Older Cancer Survivors Using Supplements | inflammation | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04898023 | Zinc and Green Tea Extract for Community Respiratory Viral Infections | viral disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02329600 | Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus | oral lichen planus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03864042 | Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors | metastatic melanoma | Caffeine (NPC256849) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00495092 | Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients | cocaine dependence | Caffeine (NPC256849) | NP level |
| NCT00692510 | Drug Interaction Study Between AZD3480 and Cytochrome P450 | Alzheimer disease | Caffeine (NPC256849) | NP level |
| NCT02594358 | Caffeine in Amblyopia Study | amblyopia | Caffeine (NPC256849) | NP level |
| NCT03022838 | The Effects of Caffeine Withdrawal on Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT00003197 | Green Tea Extract in Treating Patients With Advanced Solid Tumors | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03970798 | A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT00951834 | Sunphenon EGCg (Epigallocatechin-Gallate) in the Early Stage of Alzheimer´s Disease | Alzheimer disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02832336 | The Effect of Caffeine on the Narcoleptic Patients | narcolepsy | Caffeine (NPC256849) | NP level |
| NCT05445232 | A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants | obesity | Caffeine (NPC256849) | NP level |
| NCT00516243 | Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01289561 | Combined Effects of Alcohol and Caffeine | alcohol dependence | Caffeine (NPC256849) | NP level |
| NCT05170464 | The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation | memory impairment | Caffeine (NPC256849) | NP level |
| NCT01738178 | Caffeine as a Therapy for Parkinson's Disease | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT01248468 | Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT00726726 | Drug Interaction Study With a Potential Alzheimer's Disease Compound | Alzheimer disease | Caffeine (NPC256849) | NP level |
| NCT00449982 | Efficacy and Safety Study of Polyphenon E to Treat External Genital Warts | anogenital venereal wart | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00917735 | Green Tea and Reduction of Breast Cancer Risk | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00799890 | Sunphenon in Progressive Forms of Multiple Sclerosis | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01172405 | Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache | Headache | Caffeine (NPC256849) | NP level |
| NCT02063802 | Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00377975 | "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat | obesity | Caffeine (NPC256849) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT02647086 | Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD) | atopic eczema | Caffeine (NPC256849) | NP level |
| NCT02875691 | Effect of Green Tea on Treatment of Lupus | systemic lupus erythematosus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03278925 | Defined Green Tea Catechin Extract in Preventing Liver Cancer in Participants With Cirrhosis | cirrhosis of liver | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01416480 | Clinical Trial to Evaluate the Safety and Efficacy of "Theobromine Capsule" as an Antitussive in Acute Cougher | bronchial disease | Theobromine (NPC119133) | NP level |
| NCT03131973 | Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin | rheumatoid arthritis | Caffeine (NPC256849) | NP level |
| NCT02740712 | Pharmacokinetic Drug-Drug Interaction Study of Rucaparib | neoplasm | Caffeine (NPC256849) | NP level |
| NCT00443170 | A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects | anemia (phenotype) | Caffeine (NPC256849) | NP level |
| NCT00564824 | The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease | coronary artery disease | Caffeine (NPC256849) | NP level |
| NCT03358706 | A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis | Crohn's disease;ulcerative colitis | Caffeine (NPC256849) | NP level |
| NCT02974114 | Exploratory Study to Investigate Cognition Function and Mobility in Individuals With Pain | pain | Caffeine (NPC256849) | NP level |
| NCT00088946 | Erlotinib and Green Tea Extract (Polyphenon® E) in Preventing Cancer Recurrence in Former Smokers Who Have Undergone Surgery for Bladder Cancer | urinary bladder cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00951964 | Treatment of Epidermolysis Bullosa Dystrophica by Polyphenon E (Epigallocatechin 3 Gallate) | Dystrophic epidermolysis bullosa | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04504045 | Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Caffeine (NPC256849) | NP level |
| NCT00461942 | Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients | Parkinson disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00836719 | Safety of Polyphenon E in Multiple Sclerosis Pilot Study | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00471952 | Maxalt 10mg Plus Caffeine 75mg in the Acute Treatment of Migraine Headache | migraine with aura;migraine without aura | Caffeine (NPC256849) | NP level |
| NCT01842633 | Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache | pain | Caffeine (NPC256849) | NP level |
| NCT01596647 | Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors | neoplasm | Caffeine (NPC256849) | NP level |
| NCT04872270 | Pain Management After Shoulder Arthroplasty | pain | Caffeine (NPC256849) | NP level |
| NCT01855971 | "Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX) | fragile X syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02225093 | A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer | prostate cancer | Caffeine (NPC256849) | NP level |
| NCT01875159 | Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm | hypoxia | Caffeine (NPC256849) | NP level |
| NCT04177693 | Pharmacokinetics and Hepatic Safety of EGCG | uterine fibroid | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01686646 | Effects of Two Doses of a Common Cold Treatment on Alertness | common cold | Caffeine (NPC256849) | NP level |
| NCT01060345 | A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ | breast ductal carcinoma in situ | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02862977 | Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment | pain | Caffeine (NPC256849) | NP level |
| NCT03187496 | Drug-drug Interaction Study Between EDP-305, Midazolam, Caffeine and Rosuvastatin in Healthy Volunteers. | non-alcoholic steatohepatitis | Caffeine (NPC256849) | NP level |
| NCT01629329 | Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT02015312 | A Trial for the Treatment of Cardiac AL-Amyloidosis With the Green Tea Compound Epigallocatechin-3-gallate (TAME-AL) | AL amyloidosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01080677 | Caffeine/Propranolol Intervention for Acute Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT01357681 | Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study) | Huntington disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00942422 | Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma | multiple myeloma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03533556 | Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder | attention deficit hyperactivity disorder | Caffeine (NPC256849) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT00676780 | Green Tea Extract and Prostate Cancer | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT01433289 | Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals | HIV infection | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01435837 | Interaction of Caffeine and Hydration on Voice | voice disorders | Caffeine (NPC256849) | NP level |
| NCT00676793 | A Study of the Effect of Polyphenon E (Green Tea Extract) on Breast Cancer Progression | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02832271 | Green Tea Extract for Endometriosis Treatment | endometriosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00459407 | Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate | prostate adenocarcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03333824 | Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer | neoplasm | Caffeine (NPC256849) | NP level |
| NCT02985671 | To Evaluate the Superiority of Fixed Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain. | Low back pain | Caffeine (NPC256849) | NP level |
| NCT02520752 | A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors | neoplasm | Caffeine (NPC256849) | NP level |
| NCT02008721 | Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach | multiple system atrophy | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT00666562 | Green Tea Extract in Treating Patients With Nonmetastatic Bladder Cancer | urinary bladder cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02772601 | This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis | psoriasis | Caffeine (NPC256849) | NP level |
| NCT02183688 | Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache Patients | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT03236662 | (-)- Epicatechin Becker Muscular Dystrophy | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT04425902 | Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults | HIV infection | Caffeine (NPC256849) | NP level |
| NCT00437632 | Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809 | substance dependence | Caffeine (NPC256849) | NP level |
| NCT01275170 | A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) | infectious disease | Caffeine (NPC256849) | NP level |
| NCT00513110 | A Possible Therapeutic Role for Adenosine During Inflammation | serum lipopolysaccharide activity | Caffeine (NPC256849) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00233935 | Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus | Barrett's esophagus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
| NCT02048215 | Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity | obesity | Caffeine (NPC256849) | NP level |
| NCT00733993 | Caffeine and Cocaine | cocaine dependence | Caffeine (NPC256849) | NP level |
| NCT01462370 | Study to Assess the Safety and Efficacy of Etoricoxib Versus Ibuprofen in the Treatment of Dysmenorrhea (MK-0663-145 AM1) | Dysmenorrhea | Caffeine (NPC256849) | NP level |
| NCT01451723 | Safety and Neuroprotective Effects of Polyphenon E in MS | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00005828 | Green Tea Extract in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00525668 | Sunphenon Epigallocatechin-gallate (EGCg) in Relapsing-remitting Multiple Sclerosis (SuniMS Study) | relapsing-remitting multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04246762 | Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4 | rheumatoid arthritis | Caffeine (NPC256849) | NP level |
| NCT00567905 | Effect of Green Tea Extract on Type 2 Diabetes | type 2 diabetes mellitus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03003000 | Ibuprofen/Caffeine Lower Back or Neck Pain Study | Back pain;Neck pain | Caffeine (NPC256849) | NP level |
| NCT02655614 | A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Caffeine (NPC256849) | NP level |
| NCT00625391 | Green Tea and Tai Chi for Bone Health | osteoporosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02891538 | Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients | malignant colon neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01636557 | A Study to Evaluate the Effect of a Single Dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Patients With Rheumatoid Arthritis | rheumatoid arthritis | Caffeine (NPC256849) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
POLB,MAPK1,TERT,PPARA,APP,ABCB1,BCL2,NFKB1,DNMT1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ACHE,AKR1B1
NCT02863575,NCT02862977,NCT02974114,NCT04872270,NCT04132336,NCT01842633,NCT01426971 |
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ACHE,NFKB1,PSMB5,FFAR4,HSD17B10,DNMT1,FABP5,ALOX15,AKR1B1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARA,NFKB1,FFAR1
NCT04504045,NCT00567905,NCT00432887,NCT00607945,NCT02627898 |
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
TERT,AKR1C3,BCL2
NCT01340599,NCT00005828,NCT00676780,NCT02225093,NCT01705652 |
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
APP,BACE1,SNCA,ACHE
NCT04570085,NCT00692510,NCT00726726,NCT00951834 |
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT01517399,NCT02520752,NCT00951158,NCT01596647,NCT03333824,NCT00091325,NCT00003197,NCT02740712
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE,SNCA
NCT01190735,NCT00459420,NCT01738178,NCT00461942,NCT03970798 |
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ELAVL3,TERT,DNMT1,FABP5,BCL2,LMNA,AKR1B1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ACHE,TERT,FFAR4,FABP5,FABP5,TERT,FFAR4
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
TERT,FABP4,DNMT1,FABP5,AKR1C3,TERT,AKR1C3
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
TERT,BCL2
NCT00516243,NCT00676793,NCT00908791,NCT00917735 |
Migraine disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SD10 |
NCT03022838,NCT01629329,NCT02183688,NCT01248468,NCT01080677,NCT02582996
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02048215,NCT05445232,NCT00377975,NCT00302289,NCT02063802,NCT00204932
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ELAVL3,APP,ACHE,SNCA,FABP5,BCL2
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
FABP3,FFAR1,APP,TERT,NR1I2,BCL2
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
TERT,DNMT1,BCL2,ABCB1
NCT00363805 |
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
AKR1B1,NFKB1
NCT01636557,NCT04246762,NCT03131973 |
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
BCL2,NFKB1
FABP5 NCT02397382,NCT02772601 |
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
NCT01451723,NCT00799890,NCT00836719,NCT00638196 |
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TERT,FABP5,ALOX15
NCT01912820,NCT00459407 |
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
FABP3,ACHE,SNCA,PGAM1,LMNA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FABP3,FFAR1,SNCA,TERT,FABP5
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MAPK1,TERT,BCL2,DNMT1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TERT,NFKB1,BCL2,DNMT1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
FABP3,FABP4,FABP5,AKR1B1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ELAVL3,ABCB1,ACHE,ALOX15
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,TERT,NR1I2,AKR1C3
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
TERT,PGD,ALOX15,ALPL
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
TERT,BCL2,DNMT1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,PPARA,FFAR1
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
BCL2,MAPK1,TERT
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
BCL2,TERT,DNMT1
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARA
FABP4 NCT03187496 |
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
TERT,BCL2
NCT00942422 |
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ACHE,TERT,AKR1B1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
NCT02647086,NCT03556592 |
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
FFAR1,ACHE
NCT02875691 |
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
TERT,FABP4,AKR1C3
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
TERT,PGD,AKR1C3
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TERT,ACHE,ALOX15
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
BCL2,DNMT1
|
Dystrophic epidermolysis bullosaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC32 |
APP
NCT00951964 |
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
APP
NCT02015312 |
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
NCT00437632 |
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TERT
NCT01661764 |
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
BCL2,TERT
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
BCL2
NCT00455416 |
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
PPARA,NFKB1
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT00088946,NCT00666562
|
Relapsing-remitting multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40.0 |
NCT01462318,NCT00525668
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT04425902,NCT01433289
|
Complete trisomy 21Disease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD40.0 |
NCT01699711,NCT01394796
|
Uterine fibroidDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E66 |
NCT05364008,NCT04177693
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00733993,NCT00495092
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT01172405,NCT01755702
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT04553666,NCT00388128
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
ALPL
NCT03358706 |
AsphyxiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.1 |
NCT03321734,NCT01875159
|
Becker muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.0 |
NCT03236662,NCT01856868
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
AKR1B1,ALPL
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
TERT,ALOX15
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE,NFKB1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
TERT,AKR1B1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
FFAR1,ALPL
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
FFAR1,LMNA
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
ELAVL3,TERT
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
FABP5,LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FABP3,ACHE,MAPKAPK5,PSMB5,FABP4,HSD17B10,BCL2,FFAR1,PPARA,DNMT1,TERT,FABP5,TDP1,NR1I2,LMNA,AKR1B1
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
FFAR1,ELAVL3,TERT,PSMB5,FFAR4,HSD17B10,POLB,PGD,PGAM1,FABP5,TDP1,ALOX15,NR1I2,ALPL,AKR1B1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
FABP3,ABCB1,APP,ACHE,SNCA,TERT,FFAR4,PGD,POLB,PGAM1,ALOX15,NR1I2,AKR1C3,LMNA
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
FABP3,ELAVL3,TERT,PSMB5,FFAR4,DNMT1,PGD,FABP5,TDP1,ALOX15,NR1I2,ALPL
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
FFAR1,SNCA,TERT,FFAR4,DNMT1,PGD,TDP1,BACE1,ALOX15,ABCB1,LMNA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
FABP3,MAPK1,APP,MAPKAPK5,ACHE,SNCA,RAD52,PGD,FABP5,PGAM1,AKR1B1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
TERT
|
Parasitic infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D0Y-1G2Z |
ALPL
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AKR1B1
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
BCL2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PPARA
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
DNMT1
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
AKR1C3
|
Diagnostic imagingDisease Category: NADisease ICD-11 Code: N.A. |
APP
|
Genetic prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E02 |
ALPL
|
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
BCL2
|
Kaposi sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B57 |
DNMT1
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
AKR1B1
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARA
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
BCL2
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
ALPL
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
BCL2
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARA
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TERT
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FFAR1
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
APP
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
PGD
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
ABCB1
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
BCL2
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
ThrombocytosisDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B63 |
TERT
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
BCL2
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TERT
|
Desmoid tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7C |
APP
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARA
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
BCL2
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
BCL2
|
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
NCT03768492
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
NCT03358706
|
OsteoporosisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83.1 |
NCT00625391
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01880866
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT02655614
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
NCT00930306
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01792310
|
Alcohol dependenceDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40.2 |
NCT01289561
|
Injury of spinal cord, level unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND51.2 |
NCT02323698
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
NCT03533556
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
NCT02832271
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
NCT01855971
|
Voice disturbances, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MA82.Z |
NCT01435837
|
Spinal painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84 |
NCT03003000
|
Columnar metaplastic epithelium of the oesophagus, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA23.Z |
NCT00233935
|
Other specified diseases of the respiratory systemDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB40.Y |
NCT01416480
|
DysmenorrhoeaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34.3 |
NCT01462370
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
NCT00223691
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00262743
|
Impairment of binocular functionsDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9D46 |
NCT02594358
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT02329600
|
Intracranial injury, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.Z |
NCT02731495
|
Ductal carcinoma in situ of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65.2 |
NCT01060345
|
Malignant neoplasms of nasopharynxDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
NCT01744587
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT00564824
|
Malignant neoplasm metastasis, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E2Z |
NCT03864042
|
DyspnoeaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.5 |
NCT02311088
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT05170464
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
NCT03928847
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT00029679
|
Bacterial infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C41 |
NCT00513110
|
Migraine with auraDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80.1 |
NCT00471952
|
NarcolepsyDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A20 |
NCT02832336
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT01999829
|
AnemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A00-3A9Z |
NCT00443170
|
Migraine without auraDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80.0 |
NCT00471952
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
NCT00596011
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT01525628
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT00707252
|
Other specified inborn errors of energy metabolismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C53.Y |
NCT04643249
|
Malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
NCT02891538
|
Other specified disorders of teeth and supporting structuresDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0A.Y |
NCT05485805
|
Cervical spine painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84.0 |
NCT03003000
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
NCT03278925
|
Infection, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1H0Z |
NCT01275170
|
Anogenital wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A95 |
NCT00449982
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
NCT04898023
|
Multiple system atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87.0 |
NCT02008721
|
Duchenne muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.1 |
NCT01183767
|
Common cold disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SA60 |
NCT01686646
|
Low back painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84.2 |
NCT02985671
|
Huntington diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01.10 |
NCT01357681
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
ALPL
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
ALPL
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
NR1I2
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AKR1C3
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FFAR4
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
FFAR1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
TERT
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
FFAR4
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
AKR1C3
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
