Plant ID: NPO28372
Plant Latin Name: Corydalis Pallida
Taxonomy Genus: Corydalis
Taxonomy Family: Papaveraceae
NCBI TaxonomyDB:
38903
Plant-of-the-World-Online:
n.a.
China
Ingredient ID: NPC98535
Ingredient ID: NPC97556
Ingredient ID: NPC97291
Ingredient ID: NPC95906
Ingredient ID: NPC94314
Ingredient ID: NPC92650
Ingredient ID: NPC87582
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Ingredient ID: NPC113773
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Ingredient ID: NPC101638
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Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Therapeutic Target | Membrane receptor | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 27 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT03287791 | A Study to Evaluate Safety and Equivalence of Generic Azelaic Acid Foam and Finacea® Foam in Participants With Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT03094403 | To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical Gel | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT00855595 | Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT01493687 | Phase 3 Papulopustular Rosacea Study | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT01402297 | Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients | chronic obstructive pulmonary disease | Apocynin (NPC32163) | NP level |
NCT00617903 | Exploration of Safety and Efficacy of AzA 15% Foam Twice a Day in Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT01025635 | Safety and Efficacy of Azelaic Acid Foam, 15% in Papulopustular Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT05014906 | Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT01555463 | Safety and Efficacy of Azelaic Acid Foam, 15 % in Papulopustular Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT02120924 | A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT03680573 | The Effect of Antioxidants on Skin Blood Flow-BH4 | cardiovascular disease | Apocynin (NPC32163) | NP level |
NCT03035955 | Azelaic Acid on Demodex Counts in Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT00408330 | A Study of Azelaic Acid (AzA) 15% Gel in the Treatment of Seborrheic Dermatitis of the Face | seborrheic dermatitis | Azelaic Acid (NPC214610) | NP level |
NCT00992667 | Inhaled Apocynin Decreases Reactive Oxygen Species Concentrations in Exhaled Breath Condensate in Mild Asthmatics | asthma | Apocynin (NPC32163) | NP level |
NCT01494467 | Phase 3 Papulopustular Rosacea Study | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT04649203 | Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy | diabetic neuropathy | Succinic Acid (NPC236709) | NP level |
NCT02058628 | Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris | acne | Azelaic Acid (NPC214610) | NP level |
NCT02147691 | Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT00417937 | A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied Twice Daily Versus Once Daily | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT03680638 | The Effect of Antioxidants on Skin Blood Flow During Local Heating | cardiovascular disease | Apocynin (NPC32163) | NP level |
NCT01387048 | Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin | acne | Azelaic Acid (NPC214610) | NP level |
NCT03418610 | Azelaic Acid Foam 15% in the Treatment of Papulopustular Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT01257919 | Safety and Pharmacokinetics of Azelaic Acid Foam, 15% in Papulopustular Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT00403949 | A Study of Azelaic Acid (AzA) 15% in Topical Treatment of Mild to Moderate Perioral Dermatitis | Dermatitis, Perioral | Azelaic Acid (NPC214610) | NP level |
NCT02800148 | Bioequivalence Study of Two Treatments in the Treatment of Inflammatory Lesions of Rosacea on the Face | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT03689010 | To Evaluate the Therapeutic Equivalence and Safety in Treatment of Moderate Facial Rosacea | rosacea | Azelaic Acid (NPC214610) | NP level |
NCT00031096 | Comparison of Efficacy and Safety of Azelaic Acid 15% Gel With Its Vehicle in Subjects With Mild to Moderate Acne | acne | Azelaic Acid (NPC214610) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT01387048,NCT02058628,NCT00031096
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
F3,LMNA,SIGMAR1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
DRD1,LMNA,SIGMAR1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
DRD1,SIGMAR1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
F3,NFKB1
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
DRD1,SIGMAR1
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
SIGMAR1,DRD1
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
SIGMAR1
NCT01402297 |
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
NCT03680638,NCT03680573
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,F3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
DRD1,LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
F3,LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
NFKB1,DRD1
|
RosaceaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED90 |
NCT03287791,NCT01494467,NCT02800148,NCT01555463,NCT01025635,NCT00855595,NCT03418610,NCT00617903,NCT03689010,NCT03094403,NCT01493687,NCT03035955,NCT02120924,NCT05014906,NCT01257919,NCT02147691,NCT00417937
|
Immune system diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01-4B41 |
SIGMAR1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NFKB1
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
SomnolenceDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG42 |
SIGMAR1
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
SIGMAR1
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1
|
Neurobehavioral disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00-8A0Z |
SIGMAR1
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
SIGMAR1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CYP2D6
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
SIGMAR1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
DRD1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NFKB1
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
DRD1
|
Epileptic encephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A62 |
SIGMAR1
|
Intellectual development disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90 |
SIGMAR1
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
DRD1
|
Tic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A05 |
DRD1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NFKB1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
SIGMAR1
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
SIGMAR1
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
SIGMAR1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
SIGMAR1
|
Bulimia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B81 |
SIGMAR1
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
CYP2D6
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
SIGMAR1
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F3
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
SIGMAR1
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SIGMAR1
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT00992667
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
NCT00408330
|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT04649203
|
Periorificial dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED90.1 |
NCT00403949
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
SIGMAR1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F3
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
F3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP2D6
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP2D6
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
DRD1
|