CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Hakea Trifurcata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO28314
Plant Latin Name: Hakea Trifurcata
Taxonomy Genus: Hakea
Taxonomy Family: Proteaceae

Plant External Links:

NCBI TaxonomyDB: 1136213
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

34 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

23 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

7 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC95780

Ingredient ID: NPC88447

Ingredient ID: NPC8104

Ingredient ID: NPC78710

Ingredient ID: NPC69374

Ingredient ID: NPC40908

Ingredient ID: NPC40663

Ingredient ID: NPC34808

Ingredient ID: NPC305938

Ingredient ID: NPC285322

Ingredient ID: NPC27988

Ingredient ID: NPC26185

Ingredient ID: NPC242428

Ingredient ID: NPC236709

Ingredient ID: NPC223070

Ingredient ID: NPC220033

Ingredient ID: NPC219133

Ingredient ID: NPC218302

Ingredient ID: NPC210491

Ingredient ID: NPC203143

Ingredient ID: NPC193947

Ingredient ID: NPC190576

Ingredient ID: NPC189572

Ingredient ID: NPC182635

Ingredient ID: NPC1758

Ingredient ID: NPC175260

Ingredient ID: NPC149949

Ingredient ID: NPC14330

Ingredient ID: NPC141614

Ingredient ID: NPC13006

Ingredient ID: NPC127045

Ingredient ID: NPC118429

Ingredient ID: NPC107421

Ingredient ID: NPC102506

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Therapeutic Target	Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Therapeutic Target	Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Therapeutic Target	Ionotropic glutamate receptor	GRIK2	Glutamate receptor ionotropic kainate 2	Q13002	CHEMBL3683
Therapeutic Target	Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Therapeutic Target	Methyl-lysine/arginine binding protein	SMN1	Survival motor neuron protein	Q16637	CHEMBL1293232
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	20

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00351286	Efficacy Study of Oral L-Citrulline in Patients Taking Simvastatin With Peripheral Arterial Disease	intermittent vascular claudication;peripheral arterial disease	L-Citrulline (NPC118429)	NP level
NCT03228524	D-aspartate and Therapeutic Exercise	brain injury	D-Aspartate (NPC285322)	NP level
NCT03387046	A Pilot Study in Participants With Relapsing Remitting Multiple Sclerosis (RR-MS)	relapsing-remitting multiple sclerosis	D-Aspartate (NPC285322)	NP level
NCT02697240	A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome	sickle cell anemia	L-Citrulline (NPC118429)	NP level
NCT02104375	L-citrulline Supplementation, Cold Exposure, & Post-Exercise Muscle Ischemia	hypertension	L-Citrulline (NPC118429)	NP level
NCT01715844	L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics	asthma	L-Citrulline (NPC118429)	NP level
NCT00742534	Phase 1 Intravenous Citrulline for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants	bronchopulmonary dysplasia	L-Citrulline (NPC118429)	NP level
NCT03952234	L-Citrulline Dose Finding Safety Study in MELAS	MELAS	L-Citrulline (NPC118429)	NP level
NCT05259904	Study to Improve Deployment Related Asthma by Using L-Citrulline Supplementation	asthma	L-Citrulline (NPC118429)	NP level
NCT02801071	L-Citrulline in Patients With Post-Polio Syndrome	postpoliomyelitis syndrome	L-Citrulline (NPC118429)	NP level
NCT04649203	Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy	diabetic neuropathy	Succinic Acid (NPC236709)	NP level
NCT00343954	PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease	sickle cell anemia	L-Citrulline (NPC118429)	NP level
NCT01462591	L-citrulline Supplementation & Cold Exposure	hypertension	L-Citrulline (NPC118429)	NP level
NCT04570384	Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19	respiratory failure	L-Citrulline (NPC118429)	NP level
NCT02943161	Asthma L-Citrulline Pilot Study	asthma	L-Citrulline (NPC118429)	NP level
NCT02314689	A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell Disease	sickle cell anemia	L-Citrulline (NPC118429)	NP level
NCT02891837	L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects	acute lung injury	L-Citrulline (NPC118429)	NP level
NCT01120964	Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol	atrioventricular septal defect;ventricular septal defect	L-Citrulline (NPC118429)	NP level
NCT00223730	Chemotherapy Toxicity Reduction Via Urea Cycle Support	cancer	L-Citrulline (NPC118429)	NP level
NCT02772887	Nutraceutical Citrulline in Pregnancy	type 2 diabetes mellitus	L-Citrulline (NPC118429)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	BLM,GRIK2,GRIK3,GRIK5,GRIK1
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	BLM,GRIK3,SMN1,LMNA
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	NCT05259904,NCT02943161,NCT01715844
Sickle-cell disorder Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3A51	NCT02314689,NCT00343954,NCT02697240
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	GRIK3,GRIK2,GRIK1
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	BLM,GRIK5,LMNA
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	BLM,GRIK3,LMNA
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	SMN1,GRIK1,LMNA
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	BLM,GRIK5,GRIK2
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	BLM,GRIK3,LMNA
Muscular atrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B61	SMN2,SMN1
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	NCT01462591,NCT02104375
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	GRIK3,GRIK5
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	BLM,GRIK2
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	BLM,GRIK2
Melanoma of skin Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	GRIK3,GRIK2
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	BLM,GRIK2
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	GRIK1,LMNA
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	BLM,GRIK3
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	GRIK3,LMNA
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	GRIK3,GRIK1
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	BLM,SMN1
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	GRIK1
Substance abuse Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40	GRIK1
Epilepsy/seizure Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A61-8A6Z	GRIK1
Dissociative neurological symptom disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6B60	GRIK1
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	GRIK1
Common atrioventricular junction with atrioventricular septal defect Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA87.4	NCT01120964
Intracranial injury, unspecified Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NA07.Z	NCT03228524
Chronic arterial occlusive disease, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	NCT00351286
Relapsing-remitting multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40.0	NCT03387046
Ventricular septal defect Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.4	NCT01120964
Unspecified malignant neoplasms of unspecified sites Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D4Z	NCT00223730
Injury of lung, unspecified Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NB32.3Z	NCT02891837
Respiratory failure Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB41	NCT04570384
Melasma Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED60.1	NCT03952234
Post polio progressive muscular atrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B62	NCT02801071
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	NCT02772887
Bronchopulmonary dysplasia originating in the perinatal period Disease Category: 19.Certain conditions originating in the perinatal period Disease ICD-11 Code: KB29.0	NCT00742534
Diabetic polyneuropathy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C03.0	NCT04649203
NA Disease Category: NA Disease ICD-11 Code: NA	NCT00351286
Myelodysplastic syndromes, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A3Z	GRIK1
Osteoarthritis, unspecified Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA0Z	GRIK1
Dengue fever, unspecified Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D2Z	GRIK2
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	BLM
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	BLM
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	GRIK3
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	BLM
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	BLM
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	GRIK3
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	GRIK1
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	BLM
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	BLM
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	BLM

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Hakea Trifurcata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

34 All known Ingredients in Total

23 Ingredients with Acceptable Bioavailablity

7 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Pheochromocytoma

Diffuse large B-cell lymphomas

Asthma

Sickle-cell disorder

Carcinosarcoma of uterus

Malignant neoplasms of biliary tract, distal bile duct

Adenocarcinoma of pancreas

Mesothelioma of pleura

Adenocarcinoma of bronchus or lung

Glioblastoma of brain

Muscular atrophy

Pulmonary hypertension

Serous cystadenoma,borderline malignancy of ovary

Hepatoblastoma

Squamous cell carcinoma of bronchus or lung

Melanoma of skin

Hepatocellular carcinoma of liver

Superficial ovarian endometriosis

Malignant neoplasms of corpus uteri, unspecified

Chikungunya virus disease

Renal cell carcinoma, chromophobe type

Germ cell tumour of testis

General pain disorder

Substance abuse

Epilepsy/seizure

Dissociative neurological symptom disorder

Pain, unspecified

Common atrioventricular junction with atrioventricular septal defect

Intracranial injury, unspecified

Chronic arterial occlusive disease, unspecified

Relapsing-remitting multiple sclerosis

Ventricular septal defect

Unspecified malignant neoplasms of unspecified sites

Injury of lung, unspecified

Respiratory failure

Melasma

Post polio progressive muscular atrophy

Type 2 diabetes mellitus

Bronchopulmonary dysplasia originating in the perinatal period

Diabetic polyneuropathy

NA

Myelodysplastic syndromes, unspecified

Osteoarthritis, unspecified

Dengue fever, unspecified

Leishmaniasis

Adenocarcinoma of stomach

Other specified malignant neoplasms of kidney, except renal pelvis

Malignant neoplasms of oesophagus

Urothelial carcinoma of bladder

Malignant neoplasms of thyroid gland, unspecified

Malignant neoplasms of thymus

Invasive carcinoma of breast

Malignant neoplasms of adrenal gland

Gliomas of brain

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities