Collective Molecular Activities of the Plant: Rheum Palmatum
Plant ID: NPO28024
Plant Latin Name: Rheum Palmatum
Taxonomy Genus: Rheum
Taxonomy Family: Polygonaceae
Plant External Links:
NCBI TaxonomyDB:
137221
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; Indonesia; India; China; BulgariaTraditional Medicine System:
Kampo; TCM; Unani; Ayurveda; SiddhaMedicinal Functions:
Anticholesterolemic; Antiseptic; Antispasmodic; Antitumor; Aperient; Astringent; Cholagogue; Demulcent; Diuretic; Homeopathy; Laxative; Purgative; Stomachic; Tonic
India; Indonesia; China; Thailand; Bulgaria
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
176 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
68 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
93 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98777
Ingredient ID: NPC98583
Ingredient ID: NPC94699
Ingredient ID: NPC94583
Ingredient ID: NPC94076
Ingredient ID: NPC92999
Ingredient ID: NPC92403
Ingredient ID: NPC92117
Ingredient ID: NPC91478
Ingredient ID: NPC91382
Ingredient ID: NPC89088
Ingredient ID: NPC84568
Ingredient ID: NPC83703
Ingredient ID: NPC83300
Ingredient ID: NPC79056
Ingredient ID: NPC77784
Ingredient ID: NPC76112
Ingredient ID: NPC73137
Ingredient ID: NPC71579
Ingredient ID: NPC71270
Ingredient ID: NPC70744
Ingredient ID: NPC70622
Ingredient ID: NPC70172
Ingredient ID: NPC68324
Ingredient ID: NPC66052
Ingredient ID: NPC65530
Ingredient ID: NPC61477
Ingredient ID: NPC59303
Ingredient ID: NPC5869
Ingredient ID: NPC57465
Ingredient ID: NPC57226
Ingredient ID: NPC5029
Ingredient ID: NPC48130
Ingredient ID: NPC46958
Ingredient ID: NPC44328
Ingredient ID: NPC43812
Ingredient ID: NPC38779
Ingredient ID: NPC36357
Ingredient ID: NPC35543
Ingredient ID: NPC34864
Ingredient ID: NPC3415
Ingredient ID: NPC326639
Ingredient ID: NPC325232
Ingredient ID: NPC32283
Ingredient ID: NPC3224
Ingredient ID: NPC320207
Ingredient ID: NPC317835
Ingredient ID: NPC315417
Ingredient ID: NPC314040
Ingredient ID: NPC313979
Ingredient ID: NPC312929
Ingredient ID: NPC311430
Ingredient ID: NPC310757
Ingredient ID: NPC308597
Ingredient ID: NPC305415
Ingredient ID: NPC30432
Ingredient ID: NPC303422
Ingredient ID: NPC301384
Ingredient ID: NPC300684
Ingredient ID: NPC300274
Ingredient ID: NPC296920
Ingredient ID: NPC294902
Ingredient ID: NPC294226
Ingredient ID: NPC289322
Ingredient ID: NPC288411
Ingredient ID: NPC288089
Ingredient ID: NPC287349
Ingredient ID: NPC286622
Ingredient ID: NPC284796
Ingredient ID: NPC284498
Ingredient ID: NPC282923
Ingredient ID: NPC278329
Ingredient ID: NPC270485
Ingredient ID: NPC269064
Ingredient ID: NPC267262
Ingredient ID: NPC267205
Ingredient ID: NPC264735
Ingredient ID: NPC262911
Ingredient ID: NPC261619
Ingredient ID: NPC260681
Ingredient ID: NPC260000
Ingredient ID: NPC259016
Ingredient ID: NPC254848
Ingredient ID: NPC254847
Ingredient ID: NPC253124
Ingredient ID: NPC251552
Ingredient ID: NPC250828
Ingredient ID: NPC248668
Ingredient ID: NPC248573
Ingredient ID: NPC247364
Ingredient ID: NPC246469
Ingredient ID: NPC2458
Ingredient ID: NPC243728
Ingredient ID: NPC243089
Ingredient ID: NPC243062
Ingredient ID: NPC240074
Ingredient ID: NPC239312
Ingredient ID: NPC238629
Ingredient ID: NPC238254
Ingredient ID: NPC237435
Ingredient ID: NPC235665
Ingredient ID: NPC234689
Ingredient ID: NPC234364
Ingredient ID: NPC232189
Ingredient ID: NPC232084
Ingredient ID: NPC225710
Ingredient ID: NPC225346
Ingredient ID: NPC225243
Ingredient ID: NPC224941
Ingredient ID: NPC224765
Ingredient ID: NPC221479
Ingredient ID: NPC219876
Ingredient ID: NPC218866
Ingredient ID: NPC218423
Ingredient ID: NPC206800
Ingredient ID: NPC205250
Ingredient ID: NPC202666
Ingredient ID: NPC198260
Ingredient ID: NPC19808
Ingredient ID: NPC196954
Ingredient ID: NPC196657
Ingredient ID: NPC194850
Ingredient ID: NPC19256
Ingredient ID: NPC192173
Ingredient ID: NPC191626
Ingredient ID: NPC187443
Ingredient ID: NPC181448
Ingredient ID: NPC179969
Ingredient ID: NPC178851
Ingredient ID: NPC177058
Ingredient ID: NPC173856
Ingredient ID: NPC17308
Ingredient ID: NPC172216
Ingredient ID: NPC171280
Ingredient ID: NPC170018
Ingredient ID: NPC168829
Ingredient ID: NPC162822
Ingredient ID: NPC161571
Ingredient ID: NPC161420
Ingredient ID: NPC160512
Ingredient ID: NPC159106
Ingredient ID: NPC158157
Ingredient ID: NPC157410
Ingredient ID: NPC15658
Ingredient ID: NPC155297
Ingredient ID: NPC153500
Ingredient ID: NPC152538
Ingredient ID: NPC147418
Ingredient ID: NPC146973
Ingredient ID: NPC146837
Ingredient ID: NPC145708
Ingredient ID: NPC142860
Ingredient ID: NPC141078
Ingredient ID: NPC137816
Ingredient ID: NPC132300
Ingredient ID: NPC129815
Ingredient ID: NPC129002
Ingredient ID: NPC126029
Ingredient ID: NPC125445
Ingredient ID: NPC1249
Ingredient ID: NPC121133
Ingredient ID: NPC115022
Ingredient ID: NPC114327
Ingredient ID: NPC114179
Ingredient ID: NPC111536
Ingredient ID: NPC108455
Ingredient ID: NPC108231
Ingredient ID: NPC1075
Ingredient ID: NPC107240
Ingredient ID: NPC105591
Ingredient ID: NPC105031
Ingredient ID: NPC103540
Ingredient ID: NPC103299
Ingredient ID: NPC102639
Ingredient ID: NPC101430
Ingredient ID: NPC101116
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Cysteine protease | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | P80365 | CHEMBL3746 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 69 | |
 Plant level | 2 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00098969 | UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants | neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00256334 | Resveratrol for Patients With Colon Cancer | malignant colon neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00330096 | Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women | osteoporosis | Hesperidin (NPC79056) | NP level |
| NCT00374881 | A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects | pain | Sorbitol (NPC66052) | NP level |
| NCT00384384 | Glycyrrhetinic Acid-Effect on Serum Potassium and Insulin Resistance in Dialysis Patients | chronic kidney disease | Glycyrrhizin (NPC202666) | NP level |
| NCT00433576 | Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery | colorectal adenocarcinoma;malignant colon neoplasm;rectum cancer | Resveratrol (NPC161571) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Resveratrol (NPC161571) | NP level |
| NCT00654667 | Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome | insulin resistance | Resveratrol (NPC161571) | NP level |
| NCT00789269 | Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From a Stroke | Pneumonia|Acute Stroke | Rheum Palmatum | Plant level As single plant |
| NCT00815737 | Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage | Lung Infection|Cerebral Hemorrhage|Pneumonia | Rheum Palmatum | Plant level As single plant |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
CNR1,DPP4,HSD11B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,BCL2,TP53
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,TSHR,CA9,MMP9,ACHE,TRPA1,MMP1,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA14,CNR2,PTGS2,HSD11B1,MMP1,LMNA,DPP4,FUT7,MMP2,ALOX5,CYP1B1,SNCA,ALOX15,BCHE,CA7,HSD11B2,CA9,PGD,PTGS1,ACHE,TRPA1,CYP2C19
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
ALOX15,MMP9,MMP1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
