CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Cynanchum Stauntoni

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO2761
Plant Latin Name: Cynanchum Stauntoni
Taxonomy Genus: Cynanchum
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

47 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

40 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

22 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC96218

Ingredient ID: NPC90566

Ingredient ID: NPC90232

Ingredient ID: NPC88759

Ingredient ID: NPC79456

Ingredient ID: NPC7491

Ingredient ID: NPC74308

Ingredient ID: NPC68889

Ingredient ID: NPC64370

Ingredient ID: NPC60556

Ingredient ID: NPC49151

Ingredient ID: NPC41348

Ingredient ID: NPC309182

Ingredient ID: NPC308749

Ingredient ID: NPC304208

Ingredient ID: NPC28779

Ingredient ID: NPC282694

Ingredient ID: NPC278683

Ingredient ID: NPC273385

Ingredient ID: NPC256989

Ingredient ID: NPC239406

Ingredient ID: NPC236579

Ingredient ID: NPC233533

Ingredient ID: NPC231738

Ingredient ID: NPC223455

Ingredient ID: NPC222591

Ingredient ID: NPC217919

Ingredient ID: NPC209275

Ingredient ID: NPC208936

Ingredient ID: NPC197978

Ingredient ID: NPC191123

Ingredient ID: NPC186098

Ingredient ID: NPC1838

Ingredient ID: NPC175987

Ingredient ID: NPC163556

Ingredient ID: NPC16157

Ingredient ID: NPC161097

Ingredient ID: NPC154477

Ingredient ID: NPC152405

Ingredient ID: NPC144682

Ingredient ID: NPC13789

Ingredient ID: NPC12845

Ingredient ID: NPC127122

Ingredient ID: NPC109813

Ingredient ID: NPC106250

Ingredient ID: NPC105329

Ingredient ID: NPC101285

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Therapeutic Target	Methyl-lysine/arginine binding protein	SMN1	Survival motor neuron protein	Q16637	CHEMBL1293232
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	7

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00382629	BHT-3009 Immunotherapy in Relapsing Remitting Multiple Sclerosis	relapsing-remitting multiple sclerosis	Butylated Hydroxytoluene (NPC144682)	NP level
NCT02220673	Serial Lung Function Measurements in Healthy and Mild Asthmatic Adults After Oral Inhalation of Ethanolic Solutions Containing Two Concentrations of the Excipient Butylated Hydroxytoluene (BHT) Administered With the Respimat® B (RMT-B)	asthma	Butylated Hydroxytoluene (NPC144682)	NP level
NCT00080366	Octanol to Treat Essential Tremor	essential tremor	Octanol (NPC163556)	NP level
NCT00001986	1-Octanol to Treat Essential Tremor	essential tremor	Octanol (NPC163556)	NP level
NCT00102596	Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor	essential tremor	Octanol (NPC163556)	NP level
NCT00103974	Immunotherapy With BHT-3009 Alone or Combined With Atorvastatin in Patients With Multiple Sclerosis	multiple sclerosis	Butylated Hydroxytoluene (NPC144682)	NP level
NCT00016679	1-Octanol to Treat Essential Tremor	essential tremor	Octanol (NPC163556)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Essential tremor or related tremors Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A04.1	NCT00016679,NCT00001986,NCT00080366,NCT00102596
Muscular atrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B61	SMN1,SMN2
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CA2,CNR2
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	SMN1,CNR2
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CA2,CNR2
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	SMN1,CNR2
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CA2,CNR2
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	SMN1,CNR2
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA2
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	CNR2
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CA2
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CNR2
Inborn lipid metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52	CNR2
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA2
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	CA2
Heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10-BD1Z	CA2
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CNR2
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CA2
Essential hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00	CA2
Low bone mass disorder Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83	CA2
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	CA2
Duodenal ulcer Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA63	CA2
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	CNR2
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	CNR2
Relapsing-remitting multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40.0	NCT00382629
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	NCT02220673
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	NCT00103974
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	CA2
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CA2
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	CA2
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	CNR2
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	CA2
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CA2
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	CA2
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	CNR2
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CNR2
Human immunodeficiency virus disease without mention of tuberculosis or malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C62	CNR2
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CA2
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CA2

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Cynanchum Stauntoni

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

47 All known Ingredients in Total

40 Ingredients with Acceptable Bioavailablity

22 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Essential tremor or related tremors

Muscular atrophy

Insomnia

Diffuse large B-cell lymphomas

Adenocarcinoma of pancreas

Mesothelioma of pleura

Cytomegaloviral disease

Germ cell tumour of testis

Bacterial infection

Pain, unspecified

Breast cancer

Attention deficit hyperactivity disorder

Inborn lipid metabolism error

Seborrhoeic dermatitis

Glaucoma

Heart failure

Atopic eczema

Solid tumour/cancer

Essential hypertension

Low bone mass disorder

Rheumatoid arthritis

Duodenal ulcer

General pain disorder

Crohn disease

Relapsing-remitting multiple sclerosis

Asthma

Multiple sclerosis

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Pheochromocytoma

Leishmaniasis

Superficial ovarian endometriosis

Urothelial carcinoma of bladder

Malignant neoplasms of corpus uteri, unspecified

Malignant neoplasms of thymus

Invasive carcinoma of breast

Human immunodeficiency virus disease without mention of tuberculosis or malaria

Glioblastoma of brain

Renal cell carcinoma, chromophobe type

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities