Ingredient ID: NPC90083
Ingredient ID: NPC57567
Ingredient ID: NPC49603
Ingredient ID: NPC48342
Ingredient ID: NPC475348
Ingredient ID: NPC473388
Ingredient ID: NPC46880
Ingredient ID: NPC35682
Ingredient ID: NPC301641
Ingredient ID: NPC292487
Ingredient ID: NPC28398
Ingredient ID: NPC282680
Ingredient ID: NPC274356
Ingredient ID: NPC261271
Ingredient ID: NPC249788
Ingredient ID: NPC234152
Ingredient ID: NPC219671
Ingredient ID: NPC20560
Ingredient ID: NPC18877
Ingredient ID: NPC177167
Ingredient ID: NPC131121
Ingredient ID: NPC11554
Ingredient ID: NPC104077
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESRRB | Estrogen-related receptor beta | O95718 | CHEMBL3751 |
Therapeutic Target | Nuclear hormone receptor subfamily 3 | AR | Androgen Receptor | P10275 | CHEMBL1871 |
Therapeutic Target | Oxidoreductase | AOX1 | Aldehyde oxidase | Q06278 | CHEMBL3257 |
Therapeutic Target | Secreted protein | SHBG | Testis-specific androgen-binding protein | P04278 | CHEMBL3305 |
Therapeutic Target | Small molecule receptor (family A GPCR) | GPER1 | G-protein coupled estrogen receptor 1 | Q99527 | CHEMBL5872 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 99 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00905723 | The Effects of Isoflavone and Estrogen in Sex Response in Climacteric Women | menopause | Estradiol (NPC48342) | NP level |
NCT00775242 | Efficacy and Safety of Estradiol and Progesterone Microspheres for the Treatment of Climacteric Symptoms. | menopause | Estradiol (NPC48342) | NP level |
NCT00001481 | The Role of Hormones in Postpartum Mood Disorders | postpartum depression | Estradiol (NPC48342) | NP level |
NCT03238092 | Comparison Between Testosterone and Estradiol Over the Homogenization of Follicular Cohort | infertility | Estradiol (NPC48342) | NP level |
NCT00687739 | Prevention of Obesity in Women Via Estradiol Regulation | obesity | Estradiol (NPC48342) | NP level |
NCT00357006 | A Definitive Estrogen Patch Study (ADEPT) | schizoaffective disorder;schizophrenia | Estradiol (NPC48342) | NP level |
NCT00310531 | 3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women | Osteopenia | Estradiol (NPC48342) | NP level |
NCT00127075 | POPART'MUS: Prevention of Post Partum Relapses With Progestin and Estradiol in Multiple Sclerosis | multiple sclerosis | Estradiol (NPC48342) | NP level |
NCT02188745 | ER Reactivation Therapy for Breast Cancer | breast cancer | Estradiol (NPC48342) | NP level |
NCT00167648 | Neoadjuvant Estradiol or Androgen Deprivation in Clinically Localized Prostate Cancer | prostate carcinoma | Estradiol (NPC48342) | NP level |
NCT02792153 | Estradiol and Fear Extinction in Anorexia Nervosa (AN) | anorexia nervosa | Estradiol (NPC48342) | NP level |
NCT02847806 | Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man | hypogonadism | Estradiol (NPC48342) | NP level |
NCT00160316 | Endometrial Safety Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination | menopause | Estradiol (NPC48342) | NP level |
NCT01126801 | Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women | depressive disorder | Estradiol (NPC48342) | NP level |
NCT02995694 | A Study Comparing Estradiol Vaginal Cream to Estrace® Cream in Females With Atrophic Vaginitis | Atrophic Vaginitis | Estradiol (NPC48342) | NP level |
NCT03401047 | Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome | polycystic ovary syndrome | Estradiol (NPC48342) | NP level |
NCT04359329 | Estrogen Patch for COVID-19 Symptoms | COVID-19 | Estradiol (NPC48342) | NP level |
NCT00251082 | Vasomotoric Symptoms Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination | menopause | Estradiol (NPC48342) | NP level |
NCT00080756 | Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease | Hereditary breast and ovarian cancer syndrome | Estradiol (NPC48342) | NP level |
NCT00303784 | Prostate Adenocarcinoma TransCutaneous Hormones | prostate cancer | Estradiol (NPC48342) | NP level |
NCT02224313 | Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women | menopause | Estradiol (NPC48342) | NP level |
NCT02349113 | Effects of Acute Estrogen Therapy on Bone Formation | osteoporosis | Estradiol (NPC48342) | NP level |
NCT01923298 | Estradiol Levels in Patients Treated With Estring | breast cancer | Estradiol (NPC48342) | NP level |
NCT02195986 | A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis | Atrophic Vaginitis | Estradiol (NPC48342) | NP level |
NCT00000559 | Women's Estrogen/Progestin Lipid Lowering Hormone Atherosclerosis Regression Trial (WELL-HART) | menopause;Myocardial Ischemia | Estradiol (NPC48342) | NP level |
NCT00059228 | Clinical Trial of Estrogen for Postpartum Depression | postpartum depression | Estradiol (NPC48342) | NP level |
NCT03294538 | Study to Evaluate Equivalence of Estradiol Vaginal Cream 0.01% to Estrace® Cream 0.01% in Atrophic Vaginitis | Atrophic Vaginitis | Estradiol (NPC48342) | NP level |
NCT04265053 | Human Cerebral Blood Flow Regulation | cerebral arterial disease | Estradiol (NPC48342) | NP level |
NCT00870220 | Initiating Transdermal Estradiol Therapy in Turner's Syndrome | Turner syndrome | Estradiol (NPC48342) | NP level |
NCT00184795 | Bleed Free Treatment of Menopausal Symptoms With New Ultra Low Dose Hormonal Combinations | menopause | Estradiol (NPC48342) | NP level |
NCT04597099 | Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion | polycystic ovary syndrome | Estradiol (NPC48342) | NP level |
NCT02770365 | Comparative Safety and Efficacy of Two Treatments in the Treatment of Vulvar and Vaginal Atrophy | Atrophy | Estradiol (NPC48342) | NP level |
NCT03332303 | Study to Evaluate the Equivalence of Estradiol Vaginal Cream to Reference Standard in the Treatment of Vaginal Atrophy | Atrophic Vaginitis | Estradiol (NPC48342) | NP level |
NCT00732693 | Evaluation of Physiologic and Standard Sex Steroid Replacement Regimens in Women With Premature Ovarian Failure | Premature ovarian insufficiency | Estradiol (NPC48342) | NP level |
NCT04760691 | Pre-Exposure Prophylaxis (PrEP)- Gender Affirming Hormone Therapy (GAHT) Interactions in TGW | HIV infection | Estradiol (NPC48342) | NP level |
NCT00455962 | Effect of Race on Gonadotropin Responses | menopause | Estradiol (NPC48342) | NP level |
NCT03941730 | Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer | breast carcinoma | Estradiol (NPC48342) | NP level |
NCT00370019 | Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failure | Premature ovarian insufficiency | Estradiol (NPC48342) | NP level |
NCT00220454 | Effect of Estrogen & Stress for Postmenopausal Women | aging | Estradiol (NPC48342) | NP level |
NCT03556800 | Study to Investigate the Pharmacokinetics & Safety Following One Application of 3 Different Doses 0.5,0.75,& 1.25 gm,a Transdermal Estradiol Cream (VML-0203), in Comparison to a Single Dose of EstroGel 1.25 gm to Healthy Post-menopausal Women. | menopause | Estradiol (NPC48342) | NP level |
NCT03837015 | Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women | HIV-1 infection | Estradiol (NPC48342) | NP level |
NCT01400776 | Safety & Efficacy WC3011 (Estradiol Vaginal Cream) in the Treatment of Vulvovaginal Atrophy in Postmenopausal Women | Atrophic Vaginitis | Estradiol (NPC48342) | NP level |
NCT00302731 | Bioidentical 'Natural' Hormone Evaluation in Early Menopause | menopause | Estradiol (NPC48342) | NP level |
NCT00698035 | Vaginal Testosterone Cream vs ESTRING for Vaginal Dryness or Decreased Libido in Early Stage Breast Cancer Patients | sexual dysfunction | Estradiol (NPC48342) | NP level |
NCT03343067 | A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain | endometriosis | Estradiol (NPC48342) | NP level |
NCT03213457 | A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain | endometriosis | Estradiol (NPC48342) | NP level |
NCT00324259 | Study of Physiological and High Dose Estradiol in the Treatment of Hormone Receptor Positive Metastatic Breast Cancer | breast neoplasm | Estradiol (NPC48342) | NP level |
NCT04021017 | PRE-GAiN Bone Health Pilot Study | anorexia nervosa | Estradiol (NPC48342) | NP level |
NCT02238808 | A Study to See Whether Estrogen Can Slow the Growth of Some ER Positive Breast Cancers | breast cancer | Estradiol (NPC48342) | NP level |
NCT01973816 | MEdical Versus SUrgical Treatments of Rectal Endometriosis | endometriosis | Estradiol (NPC48342) | NP level |
NCT00837616 | Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism | Premature ovarian insufficiency | Estradiol (NPC48342) | NP level |
NCT00268476 | Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy | prostate cancer | Estradiol (NPC48342) | NP level |
NCT03240081 | Treating Postmenopausal Dyspareunia Where it Hurts | Dyspareunia | Estradiol (NPC48342) | NP level |
NCT00727129 | Study to Evaluate Divigel for the Treatment of Postmenoupausal Symptoms | menopause | Estradiol (NPC48342) | NP level |
NCT02668796 | To Study Generic Estradiol 10 mcg Vaginal Tablets in the Treatment of Vulvar and Vaginal Atrophy in Post Menopausal Women. | Atrophic Vaginitis | Estradiol (NPC48342) | NP level |
NCT00108849 | Vagifem Low Dose for Postmenopausal Atrophic Vaginitis Symptoms | Atrophic Vaginitis | Estradiol (NPC48342) | NP level |
NCT05472779 | Periurethral vs Intravaginal Estrogen for Prevention of Recurrent Urinary Tract Infections | urinary tract infection | Estradiol (NPC48342) | NP level |
NCT01779947 | Study to Evaluate the Safety and Bioequivalence of Estradiol Vaginal Inserts, 10 mcg and Vagifem® 10 mcg and Compare to Placebo | postmenopausal atrophic vaginitis | Estradiol (NPC48342) | NP level |
NCT03204318 | SPIRIT 1: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain | pain | Estradiol (NPC48342) | NP level |
NCT01265017 | Role of Pregnancy Related Hormones in Lowering the Insulin Requirement in Pregnant Women With Type 1 Diabetes | type 1 diabetes mellitus | Estradiol (NPC48342) | NP level |
NCT01942668 | A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms | menopause | Estradiol (NPC48342) | NP level |
NCT01293747 | Pharmacokinetics of Injectable Estradiol and Progesterone Microspheres Suspension | menopause | Estradiol (NPC48342) | NP level |
NCT00066157 | Alzheimer's Disease: Therapeutic Potential of Estrogen | Alzheimer disease | Estradiol (NPC48342) | NP level |
NCT01984138 | REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy | breast cancer | Estradiol (NPC48342) | NP level |
NCT00946192 | Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes | amenorrhea | Estradiol (NPC48342) | NP level |
NCT04833140 | Estrogen Administration for the Treatment of NASH in Postmenopausal Women | non-alcoholic steatohepatitis | Estradiol (NPC48342) | NP level |
NCT00413764 | Efficacy of Tibolone Versus Transdermal E2/NETA on Sexual Function in Naturally Postmenopausal Women (P06089) | sexual dysfunction | Estradiol (NPC48342) | NP level |
NCT03821415 | Effects of RP101 in Post-menopausal Women With Dry Eye Syndrome | dry eye syndrome | Estradiol (NPC48342) | NP level |
NCT01603745 | Effects of Drospirenone-ethinylestradiol and/or NOMAC-valerate Estradiol on Cardiovascular Risk in Women With Polycystic Ovary Syndrome | polycystic ovary syndrome | Estradiol (NPC48342) | NP level |
NCT00212342 | Efficacy and Safety Study of Low Dose Oral Contraceptive Pill to Treat Dysmenorrhea | Dysmenorrhea | Estradiol (NPC48342) | NP level |
NCT00864214 | A Pharmacokinetic Evaluation of Bioidentical Compounded Estrogen Cream and Natural Progesterone | menopause | Estradiol (NPC48342) | NP level |
NCT04853069 | Oestrogen Treatment for COVID-19 Symptoms | COVID-19 | Estradiol (NPC48342) | NP level |
NCT04192266 | Estrogen and Fear in PTSD | post-traumatic stress disorder | Estradiol (NPC48342) | NP level |
NCT00459810 | Paclitaxel Poliglumex and Estradiol in Treating Patients With Stage IV Prostate Cancer | prostate cancer | Estradiol (NPC48342) | NP level |
NCT01477632 | Bioavailability of Three Oral Formulations for Hormone Replacement Therapy in Postmenopausal Women | menopause | Estradiol (NPC48342) | NP level |
NCT00391417 | Efficacy and Safety of a Topical Estradiol Gel for Treatment of Postmenopausal Symptoms | Hot flashes | Estradiol (NPC48342) | NP level |
NCT00204074 | Treatment of Menstrual Migraine With Sequential, Transdermal, 17-Beta-Estradiol. A Double-Blind, Randomised, Cross-Over Trial. | migraine disorder | Estradiol (NPC48342) | NP level |
NCT04225221 | Neurobiology of Bulimia Nervosa | bulimia nervosa | Estradiol (NPC48342) | NP level |
NCT00176644 | Phase II Trial of Transdermal Estradiol for Hormone Refractory Prostate Cancer | prostate cancer | Estradiol (NPC48342) | NP level |
NCT00044837 | Hormone Replacement Therapy and Anti-HIV Drugs in HIV-Infected, Postmenopausal Women | HIV infection | Estradiol (NPC48342) | NP level |
NCT00140998 | Estrogen Treatment (Oral vs. Patches) in Turner Syndrome | Turner syndrome;Premature ovarian insufficiency | Estradiol (NPC48342) | NP level |
NCT03654274 | SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain | endometriosis | Estradiol (NPC48342) | NP level |
NCT00661531 | Estrogen in Postmenopausal Women With ER Positive Metastatic Breast Cancer After Failure of Sequential Endocrine Therapy | breast carcinoma | Estradiol (NPC48342) | NP level |
NCT01710696 | Induction of Puberty With 17-beta Estradiol in Girls With Turner Syndrome | Turner syndrome | Estradiol (NPC48342) | NP level |
NCT00328497 | A Combination Study to Determine the Safety and Efficacy of Panzem NCD With Avastin in Metastatic Carcinoid Tumors | carcinoid tumor | Estradiol (NPC48342) | NP level |
NCT01810315 | Influence of Reproductive Cycle and Menopause on HIV-1 Infection and TFV Gel Activity | HIV infection | Estradiol (NPC48342) | NP level |
NCT00206557 | The Use of Selective Estrogen Receptor Modulators in the Treatment of Schizophrenia- a Pilot Study | schizoaffective disorder;schizophrenia | Estradiol (NPC48342) | NP level |
NCT01301183 | Effects of Anorexia Nervosa on Peak Bone Mass | anorexia nervosa | Estradiol (NPC48342) | NP level |
NCT02516202 | The Vaginal Health Trial | Atrophic Vaginitis;menopause;Dyspareunia | Estradiol (NPC48342) | NP level |
NCT00185237 | Treatment of Hot Flushes in Asian Women With Ultra-low Dose Estradiol Patch | Hot flashes | Estradiol (NPC48342) | NP level |
NCT00114517 | ELITE: Early Versus Late Intervention Trial With Estradiol | atherosclerosis | Estradiol (NPC48342) | NP level |
NCT00003771 | Hormone Replacement Therapy and the Risk of Breast Cancer Recurrence in Women With Previous Early Stage Breast Cancer | breast cancer | Estradiol (NPC48342) | NP level |
NCT01596010 | Investigation of 2 Different Oral Formulations of Estradiol and Norethisterone in Healthy Women | menopause | Estradiol (NPC48342) | NP level |
NCT02736032 | Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist | infertility | Estradiol (NPC48342) | NP level |
NCT02467673 | Nanoparticulate Versus Micronized Steroids Delivery for Transdermal Hormone Replacement Therapy | menopause | Estradiol (NPC48342) | NP level |
NCT05387577 | Coagulation and Fibrinolysis of Estradiol in Transwomen | blood coagulation disease | Estradiol (NPC48342) | NP level |
NCT01083641 | Estrogen for Triple Negative Breast Cancer | breast cancer | Estradiol (NPC48342) | NP level |
NCT01508858 | Influence on the Effect of an Oral Contraceptive Drug After Administration of Liraglutide in Postmenopausal Women | type 2 diabetes mellitus | Estradiol (NPC48342) | NP level |
NCT03751124 | Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids | uterine fibroid | Estradiol (NPC48342) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
AR,ESR1,ESR2
NCT01923298,NCT01083641,NCT01984138,NCT02188745,NCT02238808,NCT00003771 |
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
AR,ESR2,ESR1,AOX1
NCT00303784,NCT00176644,NCT00268476,NCT00459810 |
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
AOX1,ESRRB,GPER1,CYP3A4,ESR1,ESRRA
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
ESR1
NCT01973816,NCT03654274,NCT03343067,NCT03213457 |
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
SMN1,BLM,AOX1,ESR2,AR
|
Premature ovarian failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30.6 |
NCT00140998,NCT00837616,NCT00370019,NCT00732693
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
ESRRB,ESR1,AOX1,GPER1
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ESRRB,ESRRA,ESR2
|
Male infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB04 |
ESR1
NCT03238092,NCT02736032 |
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4,ESRRA,ESRRB
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ESR2,MAPT
NCT00066157 |
DyspareuniaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA12 |
ESR1
NCT03240081,NCT02516202 |
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
ESR1
NCT03941730,NCT00661531 |
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
ESRRA
NCT00206557,NCT00357006 |
Turner syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD50.0 |
NCT01710696,NCT00870220,NCT00140998
|
Anorexia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B80 |
NCT01301183,NCT04021017,NCT02792153
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
NCT03401047,NCT04597099,NCT01603745
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT04760691,NCT01810315,NCT00044837
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ESRRB,ESR1,ESRRA
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
MAPT,BLM,ESR2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
MAPT,BLM,MAPT
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP3A4,MAPT,ESRRB
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
AOX1,AR,BLM
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
SMN1,BLM,ESRRA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CYP3A4,AR,BLM
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,AR
|
Muscular atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B61 |
SMN2,SMN1
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
ESR2,AR
|
Contact dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK00-EK0Z |
ESRRA,ESRRB
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,AR
|
Menopausal disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30 |
ESR2,ESR1
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
AR,ESR1
|
Skin diseaseDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA00-EM0Z |
ESRRB,ESRRA
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
ESRRA,ESRRB
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ESR2,ESR1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
ESRRB,ESRRA
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
ESRRB,ESRRA
|
Eyelid inflammatory disorderDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A02 |
ESRRA,ESRRB
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
AR,ESR1
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
ESR1
NCT00127075 |
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
ESR1,AR
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
ESRRA,ESRRB
|
Mental or behavioural disorders associated with pregnancy, childbirth or the puerperium, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6E20 |
NCT00059228,NCT00001481
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
NCT00206557,NCT00357006
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
NCT00698035,NCT00413764
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04853069,NCT04359329
|
Flare or flashDisease Category: X.Extension CodesDisease ICD-11 Code: XE03F |
NCT00391417,NCT00185237
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
ESRRB,ESRRA
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
MAPT,BLM
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
AOX1,SMN1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4,BLM
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ESR2,ESRRB
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
BLM,ESRRB
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
ESR1,BLM
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4,ESRRA
|
MenopauseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30.0 |
NCT00864214,NCT01596010,NCT00160316,NCT00000559,NCT00184795,NCT01293747,NCT02224313,NCT01477632,NCT03556800,NCT00251082,NCT01942668,NCT00455962,NCT02467673,NCT00775242,NCT00302731,NCT02516202,NCT00905723,NCT00727129
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Postmenopausal atrophic vaginitisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30.2 |
NCT01779947,NCT02770365,NCT02995694,NCT02195986,NCT01400776,NCT03332303,NCT02516202,NCT02668796,NCT00108849,NCT03294538
|
Skeletal anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD24 |
ESR1
|
Testicular dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A81 |
AR
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
AR
|
Hypo-osmolality/hyponatraemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C72 |
AR
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
AR
|
Menstrual cycle bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20 |
ESR1
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
AR
|
Degenerative high myopiaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B76 |
ESRRA
|
Muscle disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB32-FB3Z |
AR
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
MAPT
|
Vitamin deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B55-5B5F |
AOX1
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAPT
|
Female genital tract noninflammatory disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA1Y |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
ESR2
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AR
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
AR
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
MAPT
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
GPER1
|
SepsisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G40-1G41 |
ESR2
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
ESR2
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
ESR1
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
ESR1
|
Female infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA31 |
ESR1
|
Mammary tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Z |
AR
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ESRRA
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
ESR1
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
AR
|
Metastatic tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E2Z |
ESR1
|
AlopeciaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED70 |
AR
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
ESR2
|
VaginitisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA02 |
ESR1
|
Alcoholic liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB94 |
AR
|
Neoplasms of unknown behaviour of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F95 |
NCT00324259
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT01126801
|
Uterine fibroidDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E66 |
NCT03751124
|
Bulimia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B81 |
NCT04225221
|
Hereditary breast and ovarian cancer syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C65 |
NCT00080756
|
Migraine disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SD10 |
NCT00204074
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT00687739
|
AmenorrhoeaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20.0 |
NCT00946192
|
Post-traumatic stress disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B40 |
NCT04192266
|
OsteoporosisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83.1 |
NCT02349113
|
Type1diabetesmellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10 |
NCT01265017
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
NCT00114517
|
Malignant neoplasms of prostate, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.Z |
NCT00167648
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT00000559
|
Urinary tract infectionDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC08 |
NCT05472779
|
Neuroendocrine tumour, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH8DS0 |
NCT00328497
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
NCT04833140
|
Blood-forming organ diseaseDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3C0Z |
NCT05387577
|
Human immunodeficiency virus type 1Disease Category: X.Extension CodesDisease ICD-11 Code: XN8LD |
NCT03837015
|
OsteopeniaDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83.0 |
NCT00310531
|
Gonadotropin deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A61.2 |
NCT02847806
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NCT01508858
|
Asymptomatic stenosis of intracranial or extracranial arteryDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD55 |
NCT04265053
|
Diseases of the visual system, unspecifiedDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9E1Z |
NCT03821415
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT00220454
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT03204318
|
DysmenorrhoeaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34.3 |
NCT00212342
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
BLM
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
BLM
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
BLM
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
ESRRB
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
SHBG
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ESRRB
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
BLM
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ESRRB
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
ESRRB
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
BLM
|