Collective Molecular Activities of the Plant: Humulus Japonicus
Plant ID: NPO2722
Plant Latin Name: Humulus Japonicus
Taxonomy Genus: Humulus
Taxonomy Family: Cannabaceae
Plant External Links:
NCBI TaxonomyDB:
3485
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Diuretic; Tonic
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
61 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
52 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
34 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC8996
Ingredient ID: NPC88609
Ingredient ID: NPC8747
Ingredient ID: NPC81511
Ingredient ID: NPC78500
Ingredient ID: NPC77869
Ingredient ID: NPC76336
Ingredient ID: NPC74646
Ingredient ID: NPC62765
Ingredient ID: NPC62469
Ingredient ID: NPC62290
Ingredient ID: NPC5908
Ingredient ID: NPC50898
Ingredient ID: NPC488135
Ingredient ID: NPC488134
Ingredient ID: NPC488133
Ingredient ID: NPC488132
Ingredient ID: NPC45173
Ingredient ID: NPC42372
Ingredient ID: NPC35961
Ingredient ID: NPC34258
Ingredient ID: NPC32163
Ingredient ID: NPC312132
Ingredient ID: NPC306397
Ingredient ID: NPC306296
Ingredient ID: NPC29883
Ingredient ID: NPC297643
Ingredient ID: NPC29763
Ingredient ID: NPC288932
Ingredient ID: NPC279121
Ingredient ID: NPC278434
Ingredient ID: NPC277400
Ingredient ID: NPC27699
Ingredient ID: NPC275463
Ingredient ID: NPC270849
Ingredient ID: NPC259512
Ingredient ID: NPC258425
Ingredient ID: NPC242242
Ingredient ID: NPC24101
Ingredient ID: NPC23508
Ingredient ID: NPC227211
Ingredient ID: NPC220225
Ingredient ID: NPC214153
Ingredient ID: NPC209846
Ingredient ID: NPC203819
Ingredient ID: NPC195749
Ingredient ID: NPC191254
Ingredient ID: NPC189142
Ingredient ID: NPC180058
Ingredient ID: NPC175575
Ingredient ID: NPC174285
Ingredient ID: NPC173160
Ingredient ID: NPC150642
Ingredient ID: NPC144682
Ingredient ID: NPC139548
Ingredient ID: NPC138370
Ingredient ID: NPC136473
Ingredient ID: NPC126354
Ingredient ID: NPC117804
Ingredient ID: NPC117237
Ingredient ID: NPC111888
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 65 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00002801 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00003925 | Combination Chemotherapy In Treating Patients With Advanced Cancer | neoplasm | Uracil (NPC27699) | NP level |
| NCT00004860 | Fluorouracil-Uracil and Leucovorin in Treating Elderly Patients With Metastatic Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00005608 | Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer | breast cancer | Uracil (NPC27699) | NP level |
| NCT00009815 | Combination Chemotherapy in Treating Patients With Advanced Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00009828 | Paclitaxel Combined With Fluorouracil-Uracil and Leucovorin in Treating Patients With Solid Tumors | neoplasm | Uracil (NPC27699) | NP level |
| NCT00033436 | Radiation Therapy With or Without Carbogen and Niacinamide in Treating Patients With Bladder Cancer | urinary bladder cancer | Niacinamide (NPC306397) | NP level |
| NCT00037089 | A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer | neoplasm of esophagus | Uracil (NPC27699) | NP level |
| NCT00103974 | Immunotherapy With BHT-3009 Alone or Combined With Atorvastatin in Patients With Multiple Sclerosis | multiple sclerosis | Butylated Hydroxytoluene (NPC144682) | NP level |
| NCT00152178 | The Comparative Trial of UFT + TAM With CMF + TAM in Adjuvant Therapy for Breast Cancer (CUBC) | breast cancer | Uracil (NPC27699) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03626298
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT04843553
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,AKR1B1
|
Acute kidney failure, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60.Z |
NCT02701127
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
GSK3B,FLT3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,THPO,MMP12,ACHE,XDH,CA9,CA7,TTR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
DPP4,LMNA,CA2,ACHE,XDH,DRD1,NAPRT,CYP1B1,CA9,CA7,TTR,HIF1A
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TTR,NOX4
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP12,DRD1,CYP19A1,NOX4
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
