Collective Molecular Activities of the Plant: Carapichea Ipecacuanha
Country/Region:
Brazil; Malaysia; Indonesia; India; Sri LankaTraditional Medicine System:
Unani; Indian Folk; Homeopathy; SiddhaBrazil; Indonesia; India; Costa Rica; Malaysia; Colombia; Sri Lanka; Nicaragua
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
74 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
25 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
21 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9882
Ingredient ID: NPC96115
Ingredient ID: NPC94850
Ingredient ID: NPC91887
Ingredient ID: NPC84974
Ingredient ID: NPC8210
Ingredient ID: NPC80129
Ingredient ID: NPC78990
Ingredient ID: NPC69928
Ingredient ID: NPC62139
Ingredient ID: NPC50511
Ingredient ID: NPC43860
Ingredient ID: NPC3945
Ingredient ID: NPC38977
Ingredient ID: NPC38247
Ingredient ID: NPC304109
Ingredient ID: NPC302713
Ingredient ID: NPC302044
Ingredient ID: NPC30101
Ingredient ID: NPC29893
Ingredient ID: NPC294731
Ingredient ID: NPC290582
Ingredient ID: NPC287756
Ingredient ID: NPC286400
Ingredient ID: NPC284183
Ingredient ID: NPC281239
Ingredient ID: NPC280272
Ingredient ID: NPC274935
Ingredient ID: NPC268087
Ingredient ID: NPC267414
Ingredient ID: NPC265623
Ingredient ID: NPC258605
Ingredient ID: NPC254848
Ingredient ID: NPC254196
Ingredient ID: NPC25314
Ingredient ID: NPC252685
Ingredient ID: NPC240459
Ingredient ID: NPC240042
Ingredient ID: NPC231988
Ingredient ID: NPC231479
Ingredient ID: NPC231262
Ingredient ID: NPC230301
Ingredient ID: NPC226779
Ingredient ID: NPC226778
Ingredient ID: NPC225526
Ingredient ID: NPC223613
Ingredient ID: NPC217748
Ingredient ID: NPC216816
Ingredient ID: NPC21581
Ingredient ID: NPC212291
Ingredient ID: NPC204617
Ingredient ID: NPC202348
Ingredient ID: NPC196189
Ingredient ID: NPC193127
Ingredient ID: NPC189252
Ingredient ID: NPC187022
Ingredient ID: NPC172925
Ingredient ID: NPC167990
Ingredient ID: NPC162174
Ingredient ID: NPC161658
Ingredient ID: NPC148950
Ingredient ID: NPC146104
Ingredient ID: NPC145304
Ingredient ID: NPC13826
Ingredient ID: NPC136014
Ingredient ID: NPC135117
Ingredient ID: NPC134780
Ingredient ID: NPC13199
Ingredient ID: NPC128766
Ingredient ID: NPC126393
Ingredient ID: NPC115284
Ingredient ID: NPC11154
Ingredient ID: NPC111275
Ingredient ID: NPC103343
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLC2A1 | Glucose transporter | P11166 | CHEMBL2535 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 12 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00377975 | "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat | obesity | Ephedrine (NPC226778) | NP level |
| NCT01006863 | Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study | hypotension | Ephedrine (NPC226778) | NP level |
| NCT01186549 | The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection | pain | Ephedrine (NPC226778) | NP level |
| NCT01451060 | Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean | preeclampsia | Ephedrine (NPC226778) | NP level |
| NCT02048215 | Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity | obesity | Ephedrine (NPC226778) | NP level |
| NCT02277730 | A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability | hypotension | Ephedrine (NPC226778) | NP level |
| NCT02384876 | Determination of the Optimal Dose of Ephedrine in Intraoperative Arterial Hypotension of Newborns and Infants up to 6 Months of Age. | hypotension | Ephedrine (NPC226778) | NP level |
| NCT02428062 | Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly | Cognitive impairment | Ephedrine (NPC226778) | NP level |
| NCT02622126 | Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia | blood coagulation disease;hemorrhage | Ephedrine (NPC226778) | NP level |
| NCT03047109 | Ephedrine and Phenylephrine for Spinal Hypotension | hypotension | Ephedrine (NPC226778) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,ADRA2A,SLC2A1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
F2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A,EPAS1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ADRA2C
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
ADRA2A
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Blood-forming organ diseaseDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3C0Z |
NCT02622126
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
