Madagascar; Bangladesh; Cambodia; Swaziland; Laos; Australia; Cuba; Papua New Guinea; Zimbabwe; China; Thailand; Maldives; Philippines; Indonesia; Mauritius; Trinidad and Tobago; Vietnam; Angola; Myanmar; South Africa; India; Sri Lanka; Fiji
Ingredient ID: NPC85524
Ingredient ID: NPC73606
Ingredient ID: NPC72430
Ingredient ID: NPC66704
Ingredient ID: NPC54710
Ingredient ID: NPC5454
Ingredient ID: NPC49238
Ingredient ID: NPC3919
Ingredient ID: NPC3823
Ingredient ID: NPC37342
Ingredient ID: NPC312132
Ingredient ID: NPC308955
Ingredient ID: NPC307216
Ingredient ID: NPC305327
Ingredient ID: NPC300510
Ingredient ID: NPC292792
Ingredient ID: NPC288922
Ingredient ID: NPC278632
Ingredient ID: NPC26960
Ingredient ID: NPC258674
Ingredient ID: NPC257124
Ingredient ID: NPC255817
Ingredient ID: NPC255054
Ingredient ID: NPC251170
Ingredient ID: NPC25026
Ingredient ID: NPC247098
Ingredient ID: NPC236196
Ingredient ID: NPC23123
Ingredient ID: NPC229403
Ingredient ID: NPC206015
Ingredient ID: NPC202189
Ingredient ID: NPC200212
Ingredient ID: NPC193454
Ingredient ID: NPC191933
Ingredient ID: NPC18672
Ingredient ID: NPC17908
Ingredient ID: NPC178018
Ingredient ID: NPC175313
Ingredient ID: NPC174144
Ingredient ID: NPC173746
Ingredient ID: NPC168755
Ingredient ID: NPC168663
Ingredient ID: NPC163098
Ingredient ID: NPC14930
Ingredient ID: NPC148858
Ingredient ID: NPC146844
Ingredient ID: NPC136330
Ingredient ID: NPC12845
Ingredient ID: NPC113733
Ingredient ID: NPC110108
Ingredient ID: NPC109955
Ingredient ID: NPC108201
Ingredient ID: NPC103527
Ingredient ID: NPC102961
Ingredient ID: NPC101634
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Oxidoreductase | MAOB | Monoamine oxidase B | P27338 | CHEMBL2039 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 3 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01383694 | Effect Of Piperine In Patients With Oropharyngeal Dysphagia | Dysphagia | Piperine (NPC136330) | NP level |
NCT01893424 | Bioequivalence Assessment of Oral Administration Vs. Oral Spray of a Cannabinoids (Tetrahydrocannabinol and Cannabidiol) | pain | Piperine (NPC136330) | NP level |
NCT05430087 | Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients | systemic lupus erythematosus | Piperine (NPC136330) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
MAOB,LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
MAOB,LMNA
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
MAOB
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
MAOB
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOB
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
MAOB
|
Primary psychotic disorder manifestationDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A25 |
MAOB
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
MAOB
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
MAOB
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
MAOB
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
MAOB
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MAOB
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
MAOB
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAOB
|
Skin cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30-2C37 |
MAOB
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
MAOB
|
DysphagiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD93 |
NCT01383694
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT01893424
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
NCT05430087
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|