Collective Molecular Activities of the Plant: Anemarrhena Asphodeloides
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCM; KampoMedicinal Functions:
Antianxiety; Antifungal; Antiseptic; Bitter; Diuretic; Expectorant; Febrifuge; Hypoglycaemic; Laxative; Lenitive; Sedative; Tonic
India; Taiwan; China; Mongolia; South Africa
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
123 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
63 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
59 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98382
Ingredient ID: NPC98179
Ingredient ID: NPC98018
Ingredient ID: NPC97700
Ingredient ID: NPC95876
Ingredient ID: NPC94196
Ingredient ID: NPC89442
Ingredient ID: NPC88481
Ingredient ID: NPC85845
Ingredient ID: NPC85292
Ingredient ID: NPC82664
Ingredient ID: NPC81559
Ingredient ID: NPC8056
Ingredient ID: NPC75059
Ingredient ID: NPC73113
Ingredient ID: NPC67681
Ingredient ID: NPC66905
Ingredient ID: NPC61937
Ingredient ID: NPC60151
Ingredient ID: NPC51520
Ingredient ID: NPC48339
Ingredient ID: NPC48080
Ingredient ID: NPC47319
Ingredient ID: NPC45255
Ingredient ID: NPC40209
Ingredient ID: NPC39392
Ingredient ID: NPC39155
Ingredient ID: NPC35961
Ingredient ID: NPC34401
Ingredient ID: NPC326355
Ingredient ID: NPC324208
Ingredient ID: NPC322620
Ingredient ID: NPC3224
Ingredient ID: NPC321984
Ingredient ID: NPC32032
Ingredient ID: NPC3188
Ingredient ID: NPC317207
Ingredient ID: NPC31092
Ingredient ID: NPC310661
Ingredient ID: NPC309958
Ingredient ID: NPC30856
Ingredient ID: NPC306397
Ingredient ID: NPC300594
Ingredient ID: NPC300240
Ingredient ID: NPC300089
Ingredient ID: NPC29883
Ingredient ID: NPC298513
Ingredient ID: NPC295487
Ingredient ID: NPC295466
Ingredient ID: NPC292730
Ingredient ID: NPC291203
Ingredient ID: NPC289240
Ingredient ID: NPC28657
Ingredient ID: NPC278419
Ingredient ID: NPC275055
Ingredient ID: NPC273855
Ingredient ID: NPC271307
Ingredient ID: NPC271205
Ingredient ID: NPC27060
Ingredient ID: NPC270077
Ingredient ID: NPC268388
Ingredient ID: NPC26782
Ingredient ID: NPC266573
Ingredient ID: NPC265624
Ingredient ID: NPC260707
Ingredient ID: NPC257756
Ingredient ID: NPC254848
Ingredient ID: NPC254847
Ingredient ID: NPC248944
Ingredient ID: NPC245041
Ingredient ID: NPC244994
Ingredient ID: NPC242419
Ingredient ID: NPC24101
Ingredient ID: NPC230549
Ingredient ID: NPC229147
Ingredient ID: NPC228383
Ingredient ID: NPC227211
Ingredient ID: NPC225804
Ingredient ID: NPC223400
Ingredient ID: NPC21904
Ingredient ID: NPC218948
Ingredient ID: NPC217205
Ingredient ID: NPC216630
Ingredient ID: NPC216520
Ingredient ID: NPC214153
Ingredient ID: NPC209970
Ingredient ID: NPC208280
Ingredient ID: NPC207356
Ingredient ID: NPC20709
Ingredient ID: NPC201959
Ingredient ID: NPC195749
Ingredient ID: NPC194856
Ingredient ID: NPC19174
Ingredient ID: NPC191544
Ingredient ID: NPC188996
Ingredient ID: NPC182571
Ingredient ID: NPC179198
Ingredient ID: NPC175936
Ingredient ID: NPC170476
Ingredient ID: NPC167400
Ingredient ID: NPC166373
Ingredient ID: NPC165370
Ingredient ID: NPC160622
Ingredient ID: NPC157431
Ingredient ID: NPC154346
Ingredient ID: NPC146289
Ingredient ID: NPC143586
Ingredient ID: NPC142931
Ingredient ID: NPC141769
Ingredient ID: NPC138065
Ingredient ID: NPC136244
Ingredient ID: NPC134502
Ingredient ID: NPC132271
Ingredient ID: NPC131937
Ingredient ID: NPC131745
Ingredient ID: NPC130873
Ingredient ID: NPC128123
Ingredient ID: NPC127296
Ingredient ID: NPC120
Ingredient ID: NPC111833
Ingredient ID: NPC109709
Ingredient ID: NPC107482
Ingredient ID: NPC101785
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Oxidoreductase | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Therapeutic Target | Oxidoreductase | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 157 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000553 | HDL-Atherosclerosis Treatment Study (HATS) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000599 | Cholesterol-Lowering Atherosclerosis Study (CLAS) | carotid artery disease;cerebral atherosclerosis;Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00009841 | Gene Therapy in Treating Patients With Advanced Head and Neck Cancer | head and neck malignant neoplasia | Cholesterol (NPC28657) | NP level |
| NCT00033436 | Radiation Therapy With or Without Carbogen and Niacinamide in Treating Patients With Bladder Cancer | urinary bladder cancer | Niacinamide (NPC306397) | NP level |
| NCT00035542 | A Research Study to Determine the Safety and Efficacy of Glucovance Compared to Metformin and Glyburide in Children and Adolescents With Type 2 Diabetes. | type 2 diabetes mellitus | Glyburide (NPC208280) | NP level |
| NCT00035568 | A Research Study to Assess the Mechanism By Which Glucovance, Metformin, and Glyburide Work To Control Glucose Levels In Patients With Type 2 Diabetes | type 2 diabetes mellitus | Glyburide (NPC208280) | NP level |
| NCT00046462 | Determine Whether Glycemic Control is Different Between Lantus & a 3rd Oral Agent When Failure With Other Treatment | diabetes mellitus | Glyburide (NPC208280) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
NCT03626298 |
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT04843553
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
ABCC8,ABCC9,PPARG,AKR1B1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute kidney failure, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60.Z |
NCT02701127
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TSHR,SLCO1B3,SLCO1B1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
HCAR2,LMNA,PPARG,SLCO1B3,DRD1,OR51E2,HSD17B2,MAOB
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
