CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Cichorium Endivia

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO26643
Plant Latin Name: Cichorium Endivia
Taxonomy Genus: Cichorium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 114280
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

Italy; India

Traditional Medicine System:

Geographical Distribution

Italy; India

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

119 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

93 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

63 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99321

Ingredient ID: NPC94167

Ingredient ID: NPC93888

Ingredient ID: NPC85813

Ingredient ID: NPC83546

Ingredient ID: NPC79027

Ingredient ID: NPC75485

Ingredient ID: NPC62045

Ingredient ID: NPC60151

Ingredient ID: NPC55412

Ingredient ID: NPC52214

Ingredient ID: NPC50488

Ingredient ID: NPC491281

Ingredient ID: NPC491262

Ingredient ID: NPC490401

Ingredient ID: NPC489907

Ingredient ID: NPC48919

Ingredient ID: NPC47294

Ingredient ID: NPC4509

Ingredient ID: NPC45083

Ingredient ID: NPC42564

Ingredient ID: NPC424

Ingredient ID: NPC40175

Ingredient ID: NPC36002

Ingredient ID: NPC35655

Ingredient ID: NPC328447

Ingredient ID: NPC318533

Ingredient ID: NPC317120

Ingredient ID: NPC31409

Ingredient ID: NPC313955

Ingredient ID: NPC304429

Ingredient ID: NPC300098

Ingredient ID: NPC298410

Ingredient ID: NPC295038

Ingredient ID: NPC294548

Ingredient ID: NPC293427

Ingredient ID: NPC292952

Ingredient ID: NPC290319

Ingredient ID: NPC285802

Ingredient ID: NPC281686

Ingredient ID: NPC277907

Ingredient ID: NPC277525

Ingredient ID: NPC276466

Ingredient ID: NPC273965

Ingredient ID: NPC273069

Ingredient ID: NPC272614

Ingredient ID: NPC272471

Ingredient ID: NPC269919

Ingredient ID: NPC262094

Ingredient ID: NPC261831

Ingredient ID: NPC256040

Ingredient ID: NPC250667

Ingredient ID: NPC249122

Ingredient ID: NPC247945

Ingredient ID: NPC246392

Ingredient ID: NPC246224

Ingredient ID: NPC244942

Ingredient ID: NPC243728

Ingredient ID: NPC242580

Ingredient ID: NPC237812

Ingredient ID: NPC230301

Ingredient ID: NPC228346

Ingredient ID: NPC226453

Ingredient ID: NPC226027

Ingredient ID: NPC224224

Ingredient ID: NPC219143

Ingredient ID: NPC217727

Ingredient ID: NPC215412

Ingredient ID: NPC213876

Ingredient ID: NPC209451

Ingredient ID: NPC208793

Ingredient ID: NPC208094

Ingredient ID: NPC20791

Ingredient ID: NPC206276

Ingredient ID: NPC203468

Ingredient ID: NPC201767

Ingredient ID: NPC199703

Ingredient ID: NPC193142

Ingredient ID: NPC190358

Ingredient ID: NPC1898

Ingredient ID: NPC189436

Ingredient ID: NPC187770

Ingredient ID: NPC185755

Ingredient ID: NPC185556

Ingredient ID: NPC178464

Ingredient ID: NPC17810

Ingredient ID: NPC174362

Ingredient ID: NPC174246

Ingredient ID: NPC172193

Ingredient ID: NPC170084

Ingredient ID: NPC169275

Ingredient ID: NPC168990

Ingredient ID: NPC168248

Ingredient ID: NPC1682

Ingredient ID: NPC167400

Ingredient ID: NPC15702

Ingredient ID: NPC152506

Ingredient ID: NPC152451

Ingredient ID: NPC150950

Ingredient ID: NPC149496

Ingredient ID: NPC147983

Ingredient ID: NPC139954

Ingredient ID: NPC137958

Ingredient ID: NPC136014

Ingredient ID: NPC133671

Ingredient ID: NPC130683

Ingredient ID: NPC126681

Ingredient ID: NPC116775

Ingredient ID: NPC11666

Ingredient ID: NPC11433

Ingredient ID: NPC113733

Ingredient ID: NPC112890

Ingredient ID: NPC111929

Ingredient ID: NPC108758

Ingredient ID: NPC108292

Ingredient ID: NPC10781

Ingredient ID: NPC107712

Ingredient ID: NPC106508

Ingredient ID: NPC106021

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Show entries

Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Drug Transporter	SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Therapeutic Target	Enzyme	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Therapeutic Target	Enzyme	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Therapeutic Target	Enzyme	AKR1C3	Aldo-keto-reductase family 1 member C3	P42330	CHEMBL4681
Therapeutic Target	Enzyme	POLB	DNA polymerase beta	P06746	CHEMBL2392
Therapeutic Target	Fatty acid binding protein family	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Showing 1 to 10 of 44 entries

Previous1 2 3 4 5Next

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	558

Clinical trial details

Show entries

Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00000114	Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa	retinitis pigmentosa	Retinol (NPC55412)	NP level
NCT00000116	Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A	retinitis pigmentosa	Retinol (NPC55412)	NP level
NCT00000152	Randomized Trial of Beta-Carotene and Macular Degeneration	macular degeneration	Beta Carotene (NPC17810)	NP level
NCT00000161	Randomized Trials of Vitamin Supplements and Eye Disease	cataract;macular degeneration	Beta Carotene (NPC17810);Ascorbate (NPC187770)	NP level
NCT00000324	Tryptophan and Behavior Therapy for Cocaine Abuse - 1	cocaine dependence	Tryptophan (NPC203468)	NP level
NCT00000372	Glycine and D-Cycloserine in Schizophrenia	schizophrenia	Glycine (NPC126681)	NP level
NCT00000461	Harvard Atherosclerosis Reversibility Project (HARP)	Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00000482	Coronary Drug Project	Myocardial Ischemia;myocardial infarction	Niacin (NPC167400)	NP level
NCT00000512	Familial Atherosclerosis Treatment Study	Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00000541	Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)	Myocardial Ischemia	Ascorbate (NPC187770)	NP level

Showing 1 to 10 of 558 entries

Previous1 2 3 4 5…56Next

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Abdominal pelvic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD81	NCT00694564
Acne vulgaris Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED80	NCT03522922,NCT03090048
Acquired hypermelanosis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED60	TYR
Acquired hypomelanotic disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED63	TYR
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	FFAR1,PPARA,AURKB,KDR,DPP4
Acute ischaemic heart disease, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA4Z	NCT00855257
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	PIM1,AURKB,NFKB1,SRC,AXL,TP53,FLT3 NCT01842139,NCT00184054,NCT00329498
Acute myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41	NCT02929888
Acute promyelocytic leukaemia Disease Category: X.Extension Codes Disease ICD-11 Code: XH1A50	NCT03624270
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	NCT03718507,NCT04404387

Showing 1 to 10 of 396 entries

Previous1 2 3 4 5…40Next

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Cichorium Endivia

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

119 All known Ingredients in Total

93 Ingredients with Acceptable Bioavailablity

63 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Abdominal pelvic pain

Acne vulgaris

Acquired hypermelanosis

Acquired hypomelanotic disorder

Acute diabete complication

Acute ischaemic heart disease, unspecified

Acute myeloid leukaemia

Acute myocardial infarction

Acute promyelocytic leukaemia

Acute respiratory distress syndrome

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities