Collective Molecular Activities of the Plant: Ruscus Aculeatus
Country/Region:
Turkey; Israel; Italy; India; Lebanon; SpainTraditional Medicine System:
Medicinal Functions:
Antipruritic; Aperient; Deobstruent; Depurative; Diaphoretic; Diuretic; Vasoconstrictor
Turkey; Italy; India; France; Israel; Algeria; Spain; Libya; Morocco; Switzerland; Russia; Bulgaria; Romania; Albania; Portugal; Mexico; Tunisia; Lebanon; United Kingdom; Greece; Hungary; Cyprus
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
79 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
8 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
10 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96806
Ingredient ID: NPC92474
Ingredient ID: NPC79788
Ingredient ID: NPC77296
Ingredient ID: NPC7642
Ingredient ID: NPC75028
Ingredient ID: NPC72022
Ingredient ID: NPC70204
Ingredient ID: NPC6828
Ingredient ID: NPC66995
Ingredient ID: NPC66667
Ingredient ID: NPC64242
Ingredient ID: NPC55920
Ingredient ID: NPC50713
Ingredient ID: NPC479532
Ingredient ID: NPC45428
Ingredient ID: NPC40187
Ingredient ID: NPC36565
Ingredient ID: NPC33867
Ingredient ID: NPC318215
Ingredient ID: NPC307063
Ingredient ID: NPC281471
Ingredient ID: NPC280582
Ingredient ID: NPC271585
Ingredient ID: NPC270249
Ingredient ID: NPC267753
Ingredient ID: NPC26741
Ingredient ID: NPC260833
Ingredient ID: NPC259162
Ingredient ID: NPC249288
Ingredient ID: NPC248889
Ingredient ID: NPC248500
Ingredient ID: NPC243728
Ingredient ID: NPC241720
Ingredient ID: NPC241669
Ingredient ID: NPC241199
Ingredient ID: NPC238532
Ingredient ID: NPC228892
Ingredient ID: NPC226723
Ingredient ID: NPC224999
Ingredient ID: NPC216358
Ingredient ID: NPC216257
Ingredient ID: NPC206264
Ingredient ID: NPC202229
Ingredient ID: NPC199837
Ingredient ID: NPC198160
Ingredient ID: NPC195232
Ingredient ID: NPC192074
Ingredient ID: NPC19101
Ingredient ID: NPC186806
Ingredient ID: NPC182466
Ingredient ID: NPC177818
Ingredient ID: NPC17743
Ingredient ID: NPC174668
Ingredient ID: NPC172282
Ingredient ID: NPC171615
Ingredient ID: NPC164957
Ingredient ID: NPC154738
Ingredient ID: NPC153870
Ingredient ID: NPC15378
Ingredient ID: NPC153588
Ingredient ID: NPC151968
Ingredient ID: NPC148965
Ingredient ID: NPC147335
Ingredient ID: NPC143227
Ingredient ID: NPC141136
Ingredient ID: NPC140777
Ingredient ID: NPC133948
Ingredient ID: NPC130382
Ingredient ID: NPC128986
Ingredient ID: NPC128225
Ingredient ID: NPC125892
Ingredient ID: NPC125072
Ingredient ID: NPC121797
Ingredient ID: NPC114928
Ingredient ID: NPC114687
Ingredient ID: NPC112274
Ingredient ID: NPC111607
Ingredient ID: NPC100684
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Oxidoreductase | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ALDH1A1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ALDH1A1
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
ALDH1A1
|
Parkinson diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00.0 |
ALDH1A1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
