Collective Molecular Activities of the Plant: Galenia Africana
Country/Region:
Madagascar; Zimbabwe; Angola; Swaziland; South AfricaTraditional Medicine System:
Madagascar; Angola; South Africa; Zimbabwe; Namibia; Swaziland
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
107 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
69 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
79 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98583
Ingredient ID: NPC95603
Ingredient ID: NPC94729
Ingredient ID: NPC93843
Ingredient ID: NPC91504
Ingredient ID: NPC88566
Ingredient ID: NPC86630
Ingredient ID: NPC8416
Ingredient ID: NPC79482
Ingredient ID: NPC78701
Ingredient ID: NPC78500
Ingredient ID: NPC78074
Ingredient ID: NPC76608
Ingredient ID: NPC76145
Ingredient ID: NPC67920
Ingredient ID: NPC67037
Ingredient ID: NPC66655
Ingredient ID: NPC65517
Ingredient ID: NPC62765
Ingredient ID: NPC62086
Ingredient ID: NPC59581
Ingredient ID: NPC58616
Ingredient ID: NPC58190
Ingredient ID: NPC57879
Ingredient ID: NPC52884
Ingredient ID: NPC5232
Ingredient ID: NPC51700
Ingredient ID: NPC49151
Ingredient ID: NPC4809
Ingredient ID: NPC469526
Ingredient ID: NPC46248
Ingredient ID: NPC39977
Ingredient ID: NPC38497
Ingredient ID: NPC35448
Ingredient ID: NPC34763
Ingredient ID: NPC33489
Ingredient ID: NPC32279
Ingredient ID: NPC31976
Ingredient ID: NPC312132
Ingredient ID: NPC303668
Ingredient ID: NPC297186
Ingredient ID: NPC294703
Ingredient ID: NPC292559
Ingredient ID: NPC286262
Ingredient ID: NPC281131
Ingredient ID: NPC279300
Ingredient ID: NPC276222
Ingredient ID: NPC275462
Ingredient ID: NPC272552
Ingredient ID: NPC271440
Ingredient ID: NPC268962
Ingredient ID: NPC268862
Ingredient ID: NPC268632
Ingredient ID: NPC268631
Ingredient ID: NPC263940
Ingredient ID: NPC262505
Ingredient ID: NPC259512
Ingredient ID: NPC256186
Ingredient ID: NPC253662
Ingredient ID: NPC249912
Ingredient ID: NPC23508
Ingredient ID: NPC226108
Ingredient ID: NPC225783
Ingredient ID: NPC216706
Ingredient ID: NPC208936
Ingredient ID: NPC20791
Ingredient ID: NPC206169
Ingredient ID: NPC205351
Ingredient ID: NPC202189
Ingredient ID: NPC197356
Ingredient ID: NPC193649
Ingredient ID: NPC192229
Ingredient ID: NPC188277
Ingredient ID: NPC185189
Ingredient ID: NPC18185
Ingredient ID: NPC180667
Ingredient ID: NPC179831
Ingredient ID: NPC173637
Ingredient ID: NPC170799
Ingredient ID: NPC168855
Ingredient ID: NPC166894
Ingredient ID: NPC164646
Ingredient ID: NPC163556
Ingredient ID: NPC161097
Ingredient ID: NPC158857
Ingredient ID: NPC157338
Ingredient ID: NPC153696
Ingredient ID: NPC149436
Ingredient ID: NPC147743
Ingredient ID: NPC141777
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC136771
Ingredient ID: NPC1363
Ingredient ID: NPC13238
Ingredient ID: NPC131981
Ingredient ID: NPC130209
Ingredient ID: NPC126029
Ingredient ID: NPC122768
Ingredient ID: NPC118284
Ingredient ID: NPC116775
Ingredient ID: NPC114239
Ingredient ID: NPC108811
Ingredient ID: NPC108218
Ingredient ID: NPC107586
Ingredient ID: NPC100980
Ingredient ID: NPC100112
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 53 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00080366 | Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00102596 | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00469183 | Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma | freckles | Hydroquinone (NPC65517) | NP level |
| NCT00472966 | Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma | freckles | Hydroquinone (NPC65517) | NP level |
| NCT00669071 | Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma | freckles | Hydroquinone (NPC65517) | NP level |
| NCT00885599 | Efficacy of a Naturally-derived Mouthrinse for Gingival Inflammation | gingivitis | Thymol (NPC259512) | NP level |
| NCT00927771 | Azelaic Acid Versus Hydroquinone in Melasma | freckles | Hydroquinone (NPC65517) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,KDR,DPP4,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,AXL,AURKB,NFKB1,SRC,FLT3,PIM1,RELA
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1,RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,NPSR1,BLM,TSHR,CYP2C9,XDH,CDK1,AURKB,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SNCA,BLM,CA2,ALOX15,MAOB,CA7,ABCG2,NAPRT,XDH,POLB,RECQL,DPP4,PIM1,CISD1,CES1,LMNA,HSD17B2,CYP1B1,CYP2C9,AXL,ALOX5,MET,AURKB,NPSR1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NPSR1,NOX4,BLM,CYP19A1,ALOX15,CDK1,MET,AURKB
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT05422885,NCT04946383
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
