Collective Molecular Activities of the Plant: Lithocarpus Polystachyus
Plant ID: NPO26308
Plant Latin Name: Lithocarpus Polystachyus
Taxonomy Genus: Lithocarpus
Taxonomy Family: Fagaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
22 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
8 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
16 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC836
Ingredient ID: NPC70982
Ingredient ID: NPC488286
Ingredient ID: NPC488285
Ingredient ID: NPC488284
Ingredient ID: NPC488283
Ingredient ID: NPC488282
Ingredient ID: NPC488281
Ingredient ID: NPC488280
Ingredient ID: NPC488279
Ingredient ID: NPC488278
Ingredient ID: NPC330683
Ingredient ID: NPC290791
Ingredient ID: NPC290598
Ingredient ID: NPC26065
Ingredient ID: NPC257963
Ingredient ID: NPC254509
Ingredient ID: NPC227550
Ingredient ID: NPC162481
Ingredient ID: NPC157287
Ingredient ID: NPC131408
Ingredient ID: NPC106541
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 21 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02899169 | Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF) | acute promyelocytic leukemia | Indigo (NPC209389) | NP level |
| NCT00578474 | A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes | Otitis media | Ofloxacin (NPC330683) | NP level |
| NCT02669888 | Indigo Naturalis in Treating Atopic Dermatitis Topically | atopic eczema | Indigo (NPC209389) | NP level |
| NCT01022502 | Comparison of Refined and Crude Indigo Naturalis Ointment in Treating Psoriasis | psoriasis vulgaris | Indigo (NPC209389) | NP level |
| NCT00563433 | MSI-78 Topical Cream vs. Oral Ofloxacin in the Treatment of Infected Diabetic Ulcers | diabetic foot | Ofloxacin (NPC330683) | NP level |
| NCT02099240 | Patients Response to Early Switch To Oral:Osteomyelitis Study | osteomyelitis | Ofloxacin (NPC330683) | NP level |
| NCT03933631 | Pilocarpine Use After Kahook Goniotomy | glaucoma | Ofloxacin (NPC330683) | NP level |
| NCT00563394 | MSI-78 Topical Cream vs. Oral Ofloxacin in the Treatment of Infected Diabetic Ulcers | diabetic foot | Ofloxacin (NPC330683) | NP level |
| NCT00683865 | Uncomplicated Pelvic Inflammatory Disease. Treatment With Moxifloxacin. | Pelvic Inflammatory Disease | Ofloxacin (NPC330683) | NP level |
| NCT00002850 | Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy | infection | Ofloxacin (NPC330683) | NP level |
| NCT05297123 | Treatment of Acute Myeloid Leukemia With Arsenic and All-trans Retinoid Acid | acute myeloid leukemia | Indigo (NPC209389) | NP level |
| NCT01901705 | A Study of Topical Indigo Naturalis Treatment in Patients With Mild to Moderate Plaque-type Psoriasis | psoriasis | Indigo (NPC209389) | NP level |
| NCT00480376 | Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate | infection | Ofloxacin (NPC330683) | NP level |
| NCT04062201 | Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline, Delamanid and Linezolid) With the Current South African Standard of Care | multidrug-resistant tuberculosis | Ofloxacin (NPC330683) | NP level |
| NCT00584155 | Protection From Cisplatin Ototoxicity by Lactated Ringers | hearing loss | Ofloxacin (NPC330683) | NP level |
| NCT02357407 | Development of an Adjustment Assistance Tool Dosage of Fluoroquinolones in a Population Pharmacokinetic Model | infection | Ofloxacin (NPC330683) | NP level |
| NCT00781521 | Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children | Otitis media | Ofloxacin (NPC330683) | NP level |
| NCT02424461 | Antibiotic Treatment for 7 Days Versus 14 Days in Patients With Acute Male Urinary Tract Infection | urinary tract infection | Ofloxacin (NPC330683) | NP level |
| NCT04005079 | Pilocarpine After Combined Cataract/Trabectome Surgery | ocular hypertension;open-angle glaucoma | Ofloxacin (NPC330683) | NP level |
| NCT01573910 | An Evaluation of the Safety and Efficacy of Moxifloxacin Ophthalmic Solution 0.5% ((VIGAMOX®) Versus Ofloxacin Ophthalmic Solution 0.3% in the Treatment of Bacterial Conjunctivitis in Chinese Patients | bacterial conjunctivitis | Ofloxacin (NPC330683) | NP level |
| NCT00622440 | Treatment of Anal High-grade Squamous Intraepithelial Lesions (HSIL) Through Use of a Chinese Herbal Topical Cream | anal neoplasm | Indigo (NPC209389) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT00002850,NCT00480376,NCT02357407
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
NCT00563433,NCT00563394
|
Otitis mediaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA80-AB0Z |
NCT00578474,NCT00781521
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
NCT04005079,NCT03933631
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NCT01901705,NCT01022502
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CDK2
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CDK2
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
CDK2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CDK2
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
CDK2
|
ThymomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CDK2
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
CDK2
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
CDK2
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
CDK2
|
Hearing disorderDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AB50-AB57 |
NCT00584155
|
Female pelvic inflammatory diseasesDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA05 |
NCT00683865
|
Urinary tract infectionDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC08 |
NCT02424461
|
Ocular hypertensionDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61.01 |
NCT04005079
|
Other specified conjunctivitisDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A60.Y |
NCT01573910
|
Osteomyelitis or osteitisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB84 |
NCT02099240
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT02899169
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT05297123
|
TuberculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B10-1B12 |
NCT04062201
|
Malignant neoplasms of anus or anal canalDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C00 |
NCT00622440
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT02669888
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CDK2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CDK2
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
CDK2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CDK2
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
CDK2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
