CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Annona Muricata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO26234
Plant Latin Name: Annona Muricata
Taxonomy Genus: Annona
Taxonomy Family: Annonaceae

Plant External Links:

NCBI TaxonomyDB: 13337
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

Brazil; Netherlands; Mexico; Indonesia; India; Togo; China; Nigeria

Traditional Medicine System:

Indian Folk; TCM; Siddha

Geographical Distribution

Brazil; Netherlands; Mexico; Indonesia; India; Togo; China; Nigeria

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

139 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

29 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

88 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC94167

Ingredient ID: NPC92561

Ingredient ID: NPC9251

Ingredient ID: NPC88648

Ingredient ID: NPC88645

Ingredient ID: NPC87125

Ingredient ID: NPC85778

Ingredient ID: NPC82795

Ingredient ID: NPC81010

Ingredient ID: NPC73468

Ingredient ID: NPC73195

Ingredient ID: NPC72871

Ingredient ID: NPC70381

Ingredient ID: NPC66346

Ingredient ID: NPC65930

Ingredient ID: NPC61257

Ingredient ID: NPC55412

Ingredient ID: NPC490427

Ingredient ID: NPC490424

Ingredient ID: NPC489907

Ingredient ID: NPC488632

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Ingredient ID: NPC488628

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Ingredient ID: NPC48338

Ingredient ID: NPC47844

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Ingredient ID: NPC39279

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Ingredient ID: NPC292809

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Ingredient ID: NPC287164

Ingredient ID: NPC286338

Ingredient ID: NPC283085

Ingredient ID: NPC282109

Ingredient ID: NPC280621

Ingredient ID: NPC279267

Ingredient ID: NPC279121

Ingredient ID: NPC274881

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Ingredient ID: NPC240695

Ingredient ID: NPC239871

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Ingredient ID: NPC235538

Ingredient ID: NPC234080

Ingredient ID: NPC233551

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Ingredient ID: NPC231096

Ingredient ID: NPC231009

Ingredient ID: NPC230301

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Ingredient ID: NPC213874

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Ingredient ID: NPC20791

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Ingredient ID: NPC202246

Ingredient ID: NPC201488

Ingredient ID: NPC200466

Ingredient ID: NPC196492

Ingredient ID: NPC188976

Ingredient ID: NPC187770

Ingredient ID: NPC17810

Ingredient ID: NPC171809

Ingredient ID: NPC171174

Ingredient ID: NPC171135

Ingredient ID: NPC169749

Ingredient ID: NPC169511

Ingredient ID: NPC169479

Ingredient ID: NPC1682

Ingredient ID: NPC167400

Ingredient ID: NPC167375

Ingredient ID: NPC158924

Ingredient ID: NPC156804

Ingredient ID: NPC153498

Ingredient ID: NPC152451

Ingredient ID: NPC150950

Ingredient ID: NPC148867

Ingredient ID: NPC147983

Ingredient ID: NPC144415

Ingredient ID: NPC138831

Ingredient ID: NPC136014

Ingredient ID: NPC134885

Ingredient ID: NPC134865

Ingredient ID: NPC134125

Ingredient ID: NPC132004

Ingredient ID: NPC131002

Ingredient ID: NPC130683

Ingredient ID: NPC126737

Ingredient ID: NPC125062

Ingredient ID: NPC124956

Ingredient ID: NPC116775

Ingredient ID: NPC116285

Ingredient ID: NPC114694

Ingredient ID: NPC112890

Ingredient ID: NPC1083

Ingredient ID: NPC107717

Ingredient ID: NPC103523

Ingredient ID: NPC103284

Ingredient ID: NPC101078

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Show entries

Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Drug Transporter	SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Therapeutic Target	Cysteine protease	CASP6	Caspase-6	P55212	CHEMBL3308
Therapeutic Target	Enzyme	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Therapeutic Target	Enzyme	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Therapeutic Target	Enzyme	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Therapeutic Target	Enzyme	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Therapeutic Target	Enzyme	POLB	DNA polymerase beta	P06746	CHEMBL2392

Showing 1 to 10 of 45 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	1350
Plant level	2

Clinical trial details

Show entries

Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00000114	Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa	retinitis pigmentosa	Retinol (NPC55412)	NP level
NCT00000116	Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A	retinitis pigmentosa	Retinol (NPC55412)	NP level
NCT00000152	Randomized Trial of Beta-Carotene and Macular Degeneration	macular degeneration	Beta Carotene (NPC17810)	NP level
NCT00000161	Randomized Trials of Vitamin Supplements and Eye Disease	macular degeneration	Beta Carotene (NPC17810);Ascorbate (NPC187770)	NP level
NCT00000161	Randomized Trials of Vitamin Supplements and Eye Disease	cataract	Ascorbate (NPC187770);Beta Carotene (NPC17810)	NP level
NCT00000324	Tryptophan and Behavior Therapy for Cocaine Abuse - 1	cocaine dependence	Tryptophan (NPC203468)	NP level
NCT00000461	Harvard Atherosclerosis Reversibility Project (HARP)	Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00000482	Coronary Drug Project	Myocardial Ischemia;myocardial infarction	Niacin (NPC167400)	NP level
NCT00000512	Familial Atherosclerosis Treatment Study	Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00000541	Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)	Myocardial Ischemia	Ascorbate (NPC187770)	NP level

Showing 1 to 10 of 1,352 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Abdominal pelvic pain Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD81	NCT00694564
Acne vulgaris Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED80	NCT03522922,NCT03090048
Acquired hypermelanosis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED60	TYR
Acquired hypomelanotic disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED63	TYR
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	AURKB,DPP4,AURKA,AKR1B1,KDR
Acute ischaemic heart disease, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA4Z	NCT00855257
Acute leukaemias of ambiguous lineage Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A61	NCT02419755
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	PIM1,SRC,TOP2A,AURKA,AURKB,GSK3B,TP53,AXL,FLT3 NCT03059615,NCT00329498,NCT00184054,NCT01842139,NCT03860844
Acute myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41	NCT02929888
Acute promyelocytic leukaemia Disease Category: X.Extension Codes Disease ICD-11 Code: XH1A50	NCT03624270

Showing 1 to 10 of 438 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Annona Muricata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

139 All known Ingredients in Total

29 Ingredients with Acceptable Bioavailablity

88 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Abdominal pelvic pain

Acne vulgaris

Acquired hypermelanosis

Acquired hypomelanotic disorder

Acute diabete complication

Acute ischaemic heart disease, unspecified

Acute leukaemias of ambiguous lineage

Acute myeloid leukaemia

Acute myocardial infarction

Acute promyelocytic leukaemia

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities