CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Phymatopteris Hastata

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO26228
Plant Latin Name: Phymatopteris Hastata
Taxonomy Genus: Phymatopteris
Taxonomy Family: Polypodiaceae

Plant External Links:

NCBI TaxonomyDB: 187376
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

54 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

51 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

21 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC88255

Ingredient ID: NPC84585

Ingredient ID: NPC72184

Ingredient ID: NPC68224

Ingredient ID: NPC65196

Ingredient ID: NPC63599

Ingredient ID: NPC61473

Ingredient ID: NPC60825

Ingredient ID: NPC56386

Ingredient ID: NPC53069

Ingredient ID: NPC51174

Ingredient ID: NPC51129

Ingredient ID: NPC308771

Ingredient ID: NPC305712

Ingredient ID: NPC291419

Ingredient ID: NPC289795

Ingredient ID: NPC281517

Ingredient ID: NPC279292

Ingredient ID: NPC273103

Ingredient ID: NPC260491

Ingredient ID: NPC254262

Ingredient ID: NPC239128

Ingredient ID: NPC22675

Ingredient ID: NPC224526

Ingredient ID: NPC223263

Ingredient ID: NPC212794

Ingredient ID: NPC212452

Ingredient ID: NPC211203

Ingredient ID: NPC210148

Ingredient ID: NPC208104

Ingredient ID: NPC206155

Ingredient ID: NPC202009

Ingredient ID: NPC197459

Ingredient ID: NPC192768

Ingredient ID: NPC190298

Ingredient ID: NPC189960

Ingredient ID: NPC185467

Ingredient ID: NPC179400

Ingredient ID: NPC179007

Ingredient ID: NPC176482

Ingredient ID: NPC165693

Ingredient ID: NPC165395

Ingredient ID: NPC159823

Ingredient ID: NPC159082

Ingredient ID: NPC15848

Ingredient ID: NPC150648

Ingredient ID: NPC142165

Ingredient ID: NPC137074

Ingredient ID: NPC136994

Ingredient ID: NPC123965

Ingredient ID: NPC122172

Ingredient ID: NPC119158

Ingredient ID: NPC111485

Ingredient ID: NPC103904

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Therapeutic Target	Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	10

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT02084004	Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment	type 2 diabetes mellitus	Berberine (NPC53069)	NP level
NCT02226185	Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence	colorectal adenoma	Berberine (NPC53069)	NP level
NCT03281096	A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer	colorectal adenoma	Berberine (NPC53069)	NP level
NCT02082756	Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment	prediabetes syndrome	Berberine (NPC53069)	NP level
NCT03486496	Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation	lung adenocarcinoma	Berberine (NPC53069)	NP level
NCT00633282	Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease	non-alcoholic fatty liver disease	Berberine (NPC53069)	NP level
NCT02861261	A Study on the Efficacy and Gut Microbiota of Berberine and Probiotics in Patients With Newly Diagnosed Type 2 Diabetes	type 2 diabetes mellitus	Berberine (NPC53069)	NP level
NCT02548832	Bezafibrate Plus Berberine in Mixed Dyslipidemia	Combined hyperlipidemia	Berberine (NPC53069)	NP level
NCT00425009	Therapeutic Effects of Berberine in Patients With Type 2 Diabetes	type 2 diabetes mellitus	Berberine (NPC53069)	NP level
NCT03333265	Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride	colorectal adenoma	Berberine (NPC53069)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	NCT02226185,NCT03281096,NCT03333265
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	NCT00425009,NCT02861261,NCT02084004
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CYP1B1,ACHE
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	CYP1B1,ACHE
Parasitic worm infestation Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F90	ACHE
Unspecific substance harmful effect Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE6Z	ACHE
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	ACHE
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	ACHE
Substance abuse Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C40	ACHE
Oesophageal/gastroduodenal disorder Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD90	ACHE
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	ACHE
Pediculosis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1G00	ACHE
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	ACHE
Myasthenia gravis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C6Y	ACHE
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	ACHE
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	ACHE
Intermediate hyperglycaemia, unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A40.Z	NCT02082756
Adenocarcinoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D40	NCT03486496
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	NCT00633282
Mixed hyperlipidaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80.2	NCT02548832
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	ACHE
Zika virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D48	ACHE
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	ACHE
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	ACHE
West Nile virus infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D46	ACHE
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	ACHE
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	ACHE
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ACHE
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	ACHE
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	CYP1B1
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	ACHE
Heart failure, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD1Z	CYP1B1
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CYP1B1
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	ACHE
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	CYP1B1
Ebola virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D60.01	ACHE

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Phymatopteris Hastata

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

54 All known Ingredients in Total

51 Ingredients with Acceptable Bioavailablity

21 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Colorectal cancer

Type 2 diabetes mellitus

Adenocarcinoma of pancreas

Malignant neoplasms of thymus

Parasitic worm infestation

Unspecific substance harmful effect

Pain, unspecified

Alzheimer disease

Substance abuse

Oesophageal/gastroduodenal disorder

Parkinsonism

Pediculosis

Glaucoma

Myasthenia gravis

Dementia

Mild neurocognitive disorder

Intermediate hyperglycaemia, unspecified

Adenocarcinoma

Non-alcoholic fatty liver disease

Mixed hyperlipidaemia

Pheochromocytoma

Zika virus disease

Diffuse large B-cell lymphomas

Other specified malignant neoplasms of kidney, except renal pelvis

West Nile virus infection

Superficial ovarian endometriosis

Malignant neoplasms of oesophagus

Cytomegaloviral disease

Systemic lupus erythematosus

Malignant neoplasms of thyroid gland, unspecified

Adenocarcinoma of bronchus or lung

Heart failure, unspecified

Glioblastoma of brain

Germ cell tumour of testis

Carpal tunnel syndrome

Ebola virus disease

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities