Collective Molecular Activities of the Plant: Vaccinium Vitis-Idaea
Country/Region:
China; Sweden; Belarus; Lithuania; FinlandTraditional Medicine System:
TCMMedicinal Functions:
Antirheumatic; Antiseptic; Astringent; Diuretic; Refrigerant; VD
Italy; Lithuania; France; Ireland; Norway; Belarus; Iceland; China; Belgium; Germany; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Sweden; Switzerland; Russia; Bulgaria; Romania; Albania; South Africa; United Kingdom; Austria; Greece; Hungary
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
152 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
93 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
105 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98583
Ingredient ID: NPC95603
Ingredient ID: NPC94729
Ingredient ID: NPC94167
Ingredient ID: NPC93843
Ingredient ID: NPC91504
Ingredient ID: NPC88566
Ingredient ID: NPC86630
Ingredient ID: NPC85813
Ingredient ID: NPC8416
Ingredient ID: NPC81010
Ingredient ID: NPC79482
Ingredient ID: NPC78701
Ingredient ID: NPC78500
Ingredient ID: NPC78074
Ingredient ID: NPC76608
Ingredient ID: NPC76145
Ingredient ID: NPC72649
Ingredient ID: NPC6984
Ingredient ID: NPC69189
Ingredient ID: NPC68903
Ingredient ID: NPC67920
Ingredient ID: NPC67037
Ingredient ID: NPC66655
Ingredient ID: NPC65517
Ingredient ID: NPC62765
Ingredient ID: NPC62086
Ingredient ID: NPC6029
Ingredient ID: NPC60151
Ingredient ID: NPC59581
Ingredient ID: NPC58616
Ingredient ID: NPC58190
Ingredient ID: NPC57879
Ingredient ID: NPC55412
Ingredient ID: NPC52884
Ingredient ID: NPC5232
Ingredient ID: NPC51700
Ingredient ID: NPC49151
Ingredient ID: NPC491218
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC490359
Ingredient ID: NPC489907
Ingredient ID: NPC48645
Ingredient ID: NPC4809
Ingredient ID: NPC46248
Ingredient ID: NPC424
Ingredient ID: NPC39977
Ingredient ID: NPC38497
Ingredient ID: NPC35448
Ingredient ID: NPC34763
Ingredient ID: NPC33489
Ingredient ID: NPC330717
Ingredient ID: NPC328447
Ingredient ID: NPC32279
Ingredient ID: NPC31976
Ingredient ID: NPC317291
Ingredient ID: NPC316518
Ingredient ID: NPC313528
Ingredient ID: NPC312132
Ingredient ID: NPC303668
Ingredient ID: NPC295644
Ingredient ID: NPC294902
Ingredient ID: NPC294703
Ingredient ID: NPC294548
Ingredient ID: NPC292559
Ingredient ID: NPC290319
Ingredient ID: NPC290294
Ingredient ID: NPC286262
Ingredient ID: NPC281131
Ingredient ID: NPC279300
Ingredient ID: NPC276222
Ingredient ID: NPC275462
Ingredient ID: NPC272552
Ingredient ID: NPC271440
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC268962
Ingredient ID: NPC268862
Ingredient ID: NPC268632
Ingredient ID: NPC268631
Ingredient ID: NPC263940
Ingredient ID: NPC262505
Ingredient ID: NPC259512
Ingredient ID: NPC256186
Ingredient ID: NPC253662
Ingredient ID: NPC249912
Ingredient ID: NPC242580
Ingredient ID: NPC236202
Ingredient ID: NPC23508
Ingredient ID: NPC226108
Ingredient ID: NPC225783
Ingredient ID: NPC216706
Ingredient ID: NPC208936
Ingredient ID: NPC20791
Ingredient ID: NPC206169
Ingredient ID: NPC203468
Ingredient ID: NPC202189
Ingredient ID: NPC199072
Ingredient ID: NPC197356
Ingredient ID: NPC193649
Ingredient ID: NPC192229
Ingredient ID: NPC189436
Ingredient ID: NPC188277
Ingredient ID: NPC187770
Ingredient ID: NPC186406
Ingredient ID: NPC185189
Ingredient ID: NPC18185
Ingredient ID: NPC180667
Ingredient ID: NPC179831
Ingredient ID: NPC17810
Ingredient ID: NPC173637
Ingredient ID: NPC171280
Ingredient ID: NPC171188
Ingredient ID: NPC170799
Ingredient ID: NPC168855
Ingredient ID: NPC168579
Ingredient ID: NPC168326
Ingredient ID: NPC167400
Ingredient ID: NPC166894
Ingredient ID: NPC164706
Ingredient ID: NPC164646
Ingredient ID: NPC163556
Ingredient ID: NPC161097
Ingredient ID: NPC159451
Ingredient ID: NPC158857
Ingredient ID: NPC157410
Ingredient ID: NPC157338
Ingredient ID: NPC153696
Ingredient ID: NPC150950
Ingredient ID: NPC149436
Ingredient ID: NPC147983
Ingredient ID: NPC147743
Ingredient ID: NPC141777
Ingredient ID: NPC139546
Ingredient ID: NPC138113
Ingredient ID: NPC136771
Ingredient ID: NPC1363
Ingredient ID: NPC133671
Ingredient ID: NPC131981
Ingredient ID: NPC130683
Ingredient ID: NPC130209
Ingredient ID: NPC126029
Ingredient ID: NPC125755
Ingredient ID: NPC122768
Ingredient ID: NPC118284
Ingredient ID: NPC116775
Ingredient ID: NPC114239
Ingredient ID: NPC108811
Ingredient ID: NPC108218
Ingredient ID: NPC100980
Ingredient ID: NPC100112
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 473 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Beta Carotene (NPC17810);Folic Acid (NPC147983);Pyridoxine (NPC269919) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Ascorbate (NPC187770);Pyridoxine (NPC269919);Beta Carotene (NPC17810);Folic Acid (NPC147983) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
NCT03522922,NCT03090048 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR,MAOB
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,FFAR1,AKR1B1,DPP4,KDR
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
SRC,PIM1,FLT3,TP53,RELA,AURKB,AXL,NFKB1
NCT00329498,NCT00184054 |
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04404387,NCT03718507
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
MMP9,XDH,TSHR,BLM,CA12,CDK1,AKR1C3,AURKB,NR1I2,CA7,MMP1,NPSR1,CYP2C9,SLCO1B1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
